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• W2022890069 abstract "Objectives. The objective of this paper is to determine if hyaluronan affects bupivacaine’s anesthetic function. Methods. Whole cell patch clamp recordings were performed on bovine articular chondrocytes cultured in 60 mm dishes. The chondrocytes were treated with phosphate-buffered saline (control group), 7.5 mg/mL hyaluronan (Orthovisc), 0.25% bupivacaine, or a mixture of 7.5 mg/mL hyaluronan and 0.25% bupivacaine. Outward currents were elicited by step depolarization from −90 mV to 150 mV with 5 mV increments and holding for 200 ms. Results. The amplitude of outward currents elicited at 150 mV was<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>607.1</mml:mn><mml:mo>±</mml:mo><mml:mn>135.4</mml:mn></mml:mrow></mml:math> pA (mean ± standard error) in the chondrocytes treated with phosphate buffered saline,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>550.0</mml:mn><mml:mo>±</mml:mo><mml:mn>194.9</mml:mn></mml:mrow></mml:math> pA in the chondrocytes treated with hyaluronan,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>18.4</mml:mn><mml:mo>±</mml:mo><mml:mn>8.3</mml:mn></mml:mrow></mml:math> pA in the chondrocytes treated with bupivacaine, and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mn>12.8</mml:mn><mml:mo>±</mml:mo><mml:mn>2.6</mml:mn></mml:mrow></mml:math> pA in the chondrocytes treated with a mixture of hyaluronan and bupivacaine. Conclusion. Hyaluronan does not affect bupivacaine’s inhibitory action on the potassium channel activities in bovine articular chondrocytes. This finding suggests that intra-articular injection of a mixture of hyaluronan and bupivacaine may not affect the anesthetic effects of bupivacaine." @default.
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• W2022890069 date "2012-01-01" @default.
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• W2022890069 title "Hyaluronan Does Not Affect Bupivacaine’s Inhibitory Action on Voltage-Gated Potassium Channel Activities in Bovine Articular Chondrocytes" @default.
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• W2022890069 doi "https://doi.org/10.1155/2012/361534" @default.
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