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• W2022890158 endingPage "438" @default.
• W2022890158 startingPage "435" @default.
• W2022890158 abstract "Cytochrome c release from mitochondria is a critical event in the apoptosis induction. Dissociation of cytochrome c from the mitochondrial inner membrane (IMM) is a necessary first step for cytochrome c release. In the present study, the effect of reactive oxygen species (ROS) on the dissociation of cytochrome c from beef-heart submitochondrial particles (SMP) and on the cardiolipin content was investigated. Exposure of SMP to mitochondrial-mediated ROS generation resulted in a large dissociation of cytochrome c from SMP and in a parallel loss of cardiolipin. Both these effects were directly and significantly correlated and also abolished by superoxide dismutase+catalase. These results demonstrate that ROS generation induces the dissociation of cytochrome c from IMM via cardiolipin peroxidation. The data may prove useful in clarifying the molecular mechanism underlying the release of cytochrome c from the mitochondria to the cytosol." @default.
• W2022890158 created "2016-06-24" @default.
• W2022890158 creator A5050129876 @default.
• W2022890158 creator A5060667731 @default.
• W2022890158 creator A5078373042 @default.
• W2022890158 creator A5091503559 @default.
• W2022890158 date "2001-11-29" @default.
• W2022890158 modified "2023-10-16" @default.
• W2022890158 title "Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome <i>c</i> dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation. Possible role in the apoptosis" @default.
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• W2022890158 doi "https://doi.org/10.1016/s0014-5793(01)03206-9" @default.
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