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- W2022890517 abstract "It is an ongoing discussion whether sulfonylureas or dipeptidyl peptidase-4 (DPP-4) inhibitors could be the first-line add-on therapy to metformin in patients with type 2 diabetes who are insufficiently controlled with metformin alone. My article was based on the results of five different head-to-head studies between sulfonylureas and DPP-4 inhibitors [1–5]. They all showed that during the length of the study period, the reduction in hemoglobin A1c (HbA1c) was similar but that changes in body weight and risk for hypoglycemia differed in favor of DPP-4 inhibitors. An obvious limitation to these studies is their limited duration (the longest study was for 2 years only). It is also known that sulfonylureas have different characteristics, and, as pointed out in the letter, that gliclazide has less risk for hypoglycemia and also is more favorable in terms of cardiovascular outcome. A final answer on the comparison between sulfonylureas and DPP-4 inhibitors requires longterm head-to-head studies that include analysis of cardiovascular risk." @default.
- W2022890517 created "2016-06-24" @default.
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- W2022890517 date "2011-09-10" @default.
- W2022890517 modified "2023-09-23" @default.
- W2022890517 title "Reply to the letter by P. Guillausseau Regarding “Sulfonylureas or Dipeptidyl Peptidase (DPP-4) Inhibitors in the Management of Type 2 Diabetes: Debate Is Not Yet Closed”" @default.
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- W2022890517 doi "https://doi.org/10.1007/s11892-011-0225-8" @default.
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