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- W2022890571 abstract "Toll-like receptors (TLRs) are a family of pattern-recognition receptors that are an important link between innate and adaptive immunity. Many established, as well as experimental, vaccines incorporate ligands for TLRs, not only to protect against infectious diseases but also in therapeutic immunization against noninfectious diseases, such as cancer. We review the underlying mechanisms by which engagement of TLR signaling pathways might trigger an adaptive immune response after immunization. Although the engagement of TLR signaling pathways is a promising mechanism for boosting vaccine responses, questions of efficacy, feasibility and safety remain the subject of active investigation. Toll-like receptors (TLRs) are a family of pattern-recognition receptors that are an important link between innate and adaptive immunity. Many established, as well as experimental, vaccines incorporate ligands for TLRs, not only to protect against infectious diseases but also in therapeutic immunization against noninfectious diseases, such as cancer. We review the underlying mechanisms by which engagement of TLR signaling pathways might trigger an adaptive immune response after immunization. Although the engagement of TLR signaling pathways is a promising mechanism for boosting vaccine responses, questions of efficacy, feasibility and safety remain the subject of active investigation." @default.
- W2022890571 created "2016-06-24" @default.
- W2022890571 creator A5021647734 @default.
- W2022890571 creator A5040597705 @default.
- W2022890571 creator A5068286313 @default.
- W2022890571 date "2006-01-01" @default.
- W2022890571 modified "2023-10-16" @default.
- W2022890571 title "Triggering TLR signaling in vaccination" @default.
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- W2022890571 doi "https://doi.org/10.1016/j.it.2005.11.005" @default.
- W2022890571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16310411" @default.
- W2022890571 hasPublicationYear "2006" @default.
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