Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022891152> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2022891152 endingPage "124" @default.
- W2022891152 startingPage "119" @default.
- W2022891152 abstract "Gadolinium-incorporating lipid-nanoemulsions (Gd-nanoLE) for neutron-capture therapy were prepared. As a more convenient administration route than the intraperitoneal (i.p.) injection previously reported, the intravenous (i.v.) injections in tumor-bearing hamsters were carried out at an administration volume of 1 ml, which was the maximum tolerable injection volume of an i.v. injection and half that of an i.p. injection. When the standard-Gd-nanoLE of 1.5 mgGd/ml was administered, the absolute bioavailability in the i.p. injection was 57%, probably resulting from incomplete absorption from the peritoneal cavity into the blood stream. The biodistribution data revealed that the i.v. injection had three advantages over the i.p. injection, namely, a faster and higher accumulation of Gd-nano LE, and a more extended retention time in the tumor. Two i.v. injections of the standard-Gd-nanoLE with a 24h interval doubled the tumor accumulation of Gd, resulting in 49.7 microg Gd/g wet tumor 12h after administration. By using a twofold Gd-enriched formulation (High-Gd-nanoLE) of 3.0 mgGd/ml in the repeated administration schedule, the accumulation was doubled again, reaching 101 microg Gd/g wet tumor. This level was comparable to the maximum level in the single i.p. injection previously reported. These results demonstrated that i.v. injection could be an alternative to i.p. injection as an administration route." @default.
- W2022891152 created "2016-06-24" @default.
- W2022891152 creator A5025561232 @default.
- W2022891152 creator A5032630701 @default.
- W2022891152 creator A5044090684 @default.
- W2022891152 date "2002-09-01" @default.
- W2022891152 modified "2023-10-01" @default.
- W2022891152 title "Tumor accumulation of gadolinium in lipid-nanoparticles intravenously injected for neutron-capture therapy of cancer" @default.
- W2022891152 cites W1990101064 @default.
- W2022891152 cites W1998715517 @default.
- W2022891152 cites W2020339179 @default.
- W2022891152 cites W2022639798 @default.
- W2022891152 cites W2043939415 @default.
- W2022891152 cites W2069695308 @default.
- W2022891152 cites W2081079938 @default.
- W2022891152 cites W2083924923 @default.
- W2022891152 cites W2099756100 @default.
- W2022891152 doi "https://doi.org/10.1016/s0939-6411(02)00085-1" @default.
- W2022891152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12191681" @default.
- W2022891152 hasPublicationYear "2002" @default.
- W2022891152 type Work @default.
- W2022891152 sameAs 2022891152 @default.
- W2022891152 citedByCount "47" @default.
- W2022891152 countsByYear W20228911522012 @default.
- W2022891152 countsByYear W20228911522013 @default.
- W2022891152 countsByYear W20228911522014 @default.
- W2022891152 countsByYear W20228911522015 @default.
- W2022891152 countsByYear W20228911522016 @default.
- W2022891152 countsByYear W20228911522018 @default.
- W2022891152 countsByYear W20228911522020 @default.
- W2022891152 countsByYear W20228911522021 @default.
- W2022891152 countsByYear W20228911522022 @default.
- W2022891152 crossrefType "journal-article" @default.
- W2022891152 hasAuthorship W2022891152A5025561232 @default.
- W2022891152 hasAuthorship W2022891152A5032630701 @default.
- W2022891152 hasAuthorship W2022891152A5044090684 @default.
- W2022891152 hasConcept C112705442 @default.
- W2022891152 hasConcept C125287762 @default.
- W2022891152 hasConcept C141071460 @default.
- W2022891152 hasConcept C159985019 @default.
- W2022891152 hasConcept C178790620 @default.
- W2022891152 hasConcept C181389837 @default.
- W2022891152 hasConcept C185592680 @default.
- W2022891152 hasConcept C192562407 @default.
- W2022891152 hasConcept C202751555 @default.
- W2022891152 hasConcept C2777807558 @default.
- W2022891152 hasConcept C2778536324 @default.
- W2022891152 hasConcept C2989005 @default.
- W2022891152 hasConcept C30421969 @default.
- W2022891152 hasConcept C501308230 @default.
- W2022891152 hasConcept C55493867 @default.
- W2022891152 hasConcept C557651011 @default.
- W2022891152 hasConcept C71924100 @default.
- W2022891152 hasConcept C98274493 @default.
- W2022891152 hasConceptScore W2022891152C112705442 @default.
- W2022891152 hasConceptScore W2022891152C125287762 @default.
- W2022891152 hasConceptScore W2022891152C141071460 @default.
- W2022891152 hasConceptScore W2022891152C159985019 @default.
- W2022891152 hasConceptScore W2022891152C178790620 @default.
- W2022891152 hasConceptScore W2022891152C181389837 @default.
- W2022891152 hasConceptScore W2022891152C185592680 @default.
- W2022891152 hasConceptScore W2022891152C192562407 @default.
- W2022891152 hasConceptScore W2022891152C202751555 @default.
- W2022891152 hasConceptScore W2022891152C2777807558 @default.
- W2022891152 hasConceptScore W2022891152C2778536324 @default.
- W2022891152 hasConceptScore W2022891152C2989005 @default.
- W2022891152 hasConceptScore W2022891152C30421969 @default.
- W2022891152 hasConceptScore W2022891152C501308230 @default.
- W2022891152 hasConceptScore W2022891152C55493867 @default.
- W2022891152 hasConceptScore W2022891152C557651011 @default.
- W2022891152 hasConceptScore W2022891152C71924100 @default.
- W2022891152 hasConceptScore W2022891152C98274493 @default.
- W2022891152 hasIssue "2" @default.
- W2022891152 hasLocation W20228911521 @default.
- W2022891152 hasLocation W20228911522 @default.
- W2022891152 hasOpenAccess W2022891152 @default.
- W2022891152 hasPrimaryLocation W20228911521 @default.
- W2022891152 hasRelatedWork W1555144605 @default.
- W2022891152 hasRelatedWork W1970245702 @default.
- W2022891152 hasRelatedWork W1970331292 @default.
- W2022891152 hasRelatedWork W2049403898 @default.
- W2022891152 hasRelatedWork W2080955156 @default.
- W2022891152 hasRelatedWork W2083067870 @default.
- W2022891152 hasRelatedWork W2379311614 @default.
- W2022891152 hasRelatedWork W2400119402 @default.
- W2022891152 hasRelatedWork W2606334551 @default.
- W2022891152 hasRelatedWork W2776273895 @default.
- W2022891152 hasVolume "54" @default.
- W2022891152 isParatext "false" @default.
- W2022891152 isRetracted "false" @default.
- W2022891152 magId "2022891152" @default.
- W2022891152 workType "article" @default.