FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022891510> ?p ?o ?g. }

• W2022891510 endingPage "17680" @default.
• W2022891510 startingPage "17675" @default.
• W2022891510 abstract "Neuroimaging studies using positron emission tomography suggest that reduced dopamine D 2 receptor availability in the neostriatum is associated with increased vulnerability to drug addiction in humans and experimental animals. The role of D 3 receptors (D 3 Rs) in the neurobiology of addiction remains unclear, however. Here we report that D 3 R KO (D 3 −/− ) mice display enhanced cocaine self-administration and enhanced motivation for cocaine-taking and cocaine-seeking behavior. This increased vulnerability to cocaine is accompanied by decreased dopamine response to cocaine secondary to increased basal levels of extracellular dopamine in the nucleus accumbens, suggesting a compensatory response to decreased cocaine reward in D 3 −/− mice. In addition, D 3 −/− mice also display up-regulation of dopamine transporters in the striatum, suggesting a neuroadaptative attempt to normalize elevated basal extracellular dopamine. These findings suggest that D 3 R deletion increases vulnerability to cocaine, and that reduced D 3 R availability in the brain may constitute a risk factor for the development of cocaine addiction." @default.
• W2022891510 created "2016-06-24" @default.
• W2022891510 creator A5026940576 @default.
• W2022891510 creator A5036210770 @default.
• W2022891510 creator A5060050668 @default.
• W2022891510 creator A5071244438 @default.
• W2022891510 creator A5079738340 @default.
• W2022891510 creator A5082151394 @default.
• W2022891510 date "2012-10-08" @default.
• W2022891510 modified "2023-10-12" @default.
• W2022891510 title "Increased vulnerability to cocaine in mice lacking dopamine D ₃ receptors" @default.
• W2022891510 cites W1481581387 @default.
• W2022891510 cites W1568132149 @default.
• W2022891510 cites W1871288096 @default.
• W2022891510 cites W1872057083 @default.
• W2022891510 cites W1922752440 @default.
• W2022891510 cites W1966233483 @default.
• W2022891510 cites W1967823110 @default.
• W2022891510 cites W1974387854 @default.
• W2022891510 cites W1978999141 @default.
• W2022891510 cites W1979565994 @default.
• W2022891510 cites W1980344452 @default.
• W2022891510 cites W1983332126 @default.
• W2022891510 cites W1984880664 @default.
• W2022891510 cites W1985856611 @default.
• W2022891510 cites W1989114600 @default.
• W2022891510 cites W1989353122 @default.
• W2022891510 cites W1997829966 @default.
• W2022891510 cites W2004470044 @default.
• W2022891510 cites W2008762508 @default.
• W2022891510 cites W2012095191 @default.
• W2022891510 cites W2018814167 @default.
• W2022891510 cites W2020860451 @default.
• W2022891510 cites W2024895660 @default.
• W2022891510 cites W2038505533 @default.
• W2022891510 cites W2041144249 @default.
• W2022891510 cites W2045731254 @default.
• W2022891510 cites W2049919185 @default.
• W2022891510 cites W2060509660 @default.
• W2022891510 cites W2062288563 @default.
• W2022891510 cites W2065497253 @default.
• W2022891510 cites W2066994135 @default.
• W2022891510 cites W2070780907 @default.
• W2022891510 cites W2072123096 @default.
• W2022891510 cites W2073212781 @default.
• W2022891510 cites W2074607412 @default.
• W2022891510 cites W2077707065 @default.
• W2022891510 cites W2078754979 @default.
• W2022891510 cites W2080684572 @default.
• W2022891510 cites W2083030968 @default.
• W2022891510 cites W2084376094 @default.
• W2022891510 cites W2085756064 @default.
• W2022891510 cites W2088522292 @default.
• W2022891510 cites W2089961803 @default.
• W2022891510 cites W2090481799 @default.
• W2022891510 cites W2103470901 @default.
• W2022891510 cites W2116795024 @default.
• W2022891510 cites W2123778240 @default.
• W2022891510 cites W2129530731 @default.
• W2022891510 cites W2134366865 @default.
• W2022891510 cites W2151323222 @default.
• W2022891510 cites W2154652846 @default.
• W2022891510 cites W2159965031 @default.
• W2022891510 cites W2166462402 @default.
• W2022891510 cites W2333240002 @default.
• W2022891510 doi "https://doi.org/10.1073/pnas.1205297109" @default.
• W2022891510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3491487" @default.
• W2022891510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23045656" @default.
• W2022891510 hasPublicationYear "2012" @default.
• W2022891510 type Work @default.
• W2022891510 sameAs 2022891510 @default.
• W2022891510 citedByCount "65" @default.
• W2022891510 countsByYear W20228915102013 @default.
• W2022891510 countsByYear W20228915102014 @default.
• W2022891510 countsByYear W20228915102015 @default.
• W2022891510 countsByYear W20228915102016 @default.
• W2022891510 countsByYear W20228915102017 @default.
• W2022891510 countsByYear W20228915102018 @default.
• W2022891510 countsByYear W20228915102019 @default.
• W2022891510 countsByYear W20228915102020 @default.
• W2022891510 countsByYear W20228915102021 @default.
• W2022891510 countsByYear W20228915102022 @default.
• W2022891510 countsByYear W20228915102023 @default.
• W2022891510 crossrefType "journal-article" @default.
• W2022891510 hasAuthorship W2022891510A5026940576 @default.
• W2022891510 hasAuthorship W2022891510A5036210770 @default.
• W2022891510 hasAuthorship W2022891510A5060050668 @default.
• W2022891510 hasAuthorship W2022891510A5071244438 @default.
• W2022891510 hasAuthorship W2022891510A5079738340 @default.
• W2022891510 hasAuthorship W2022891510A5082151394 @default.
• W2022891510 hasBestOaLocation W20228915101 @default.
• W2022891510 hasConcept C120069818 @default.
• W2022891510 hasConcept C126322002 @default.
• W2022891510 hasConcept C134018914 @default.
• W2022891510 hasConcept C137183658 @default.
• W2022891510 hasConcept C15744967 @default.
• W2022891510 hasConcept C169760540 @default.
• W2022891510 hasConcept C170493617 @default.

• next