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- W2022893491 abstract "Mesenchymal stem cells (MSCs), which evoke only minimal immune reactivity, may have anti‐inflammatory and immunomodulatory effects. In this study, we conducted a comparative analysis of the immunomodulatory properties of MSCs derived from adult human tissues including bone marrow (BM), adipose tissues (AT), umbilical cord blood (CB), and cord Wharton9s jelly (WJ). Using a multiple cytokine detection assay, we showed that there were no significant differences in levels of secreted factors from non‐stimulated MSCs. We compared the immunosuppressive effect of BM‐MSCs, AT‐MSCs, CB‐MSCs, and WJ‐MSCs on phytohemagglutinin (PHA)‐induced T‐cell proliferation. AT‐MSCs, CB‐MSCs, and WJ‐MSCs effectively suppressed PHA‐induced T‐cell proliferation as effectively as did BM‐MSCs. Levels of interferon (IFN)‐γ secreted from activated T‐cells increased over time, but these levels were significantly reduced when cocultured with each type of MSCs. In addition, the expression of hepatocyte growth factor, interleukin‐10, transforming growth factor‐β1, cyclooxygenase (COX)‐1, and COX‐2 were unchanged in MSCs treated with IFN‐γ, while that of indoleamine 2,3‐dioxygenase (IDO) increased. Use of an antagonist, 1‐methyl‐L‐tryptophan, restored T‐cell proliferation and confirmed an IDO contribution to IFN‐γ‐induced immunosuppression by MSCs. Addition of tryptophan catabolite, such as kynurenine, 3‐hydroxykynurenine, or quinolinic acid, significantly decreased PHA‐induced T‐cell proliferation. These data indicate that IFN‐γ produced by activated T‐cells were correlated with induction of IDO expression by MSCs, which, in turn, suppressed T‐cell proliferation through tryptophan depletion and the local accumulation of tryptophan catabolites. Our findings suggest that MSCs derived from AT, CB, or WJ could be substituted for BM‐MSCs for treatment of allogeneic conflicts. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):C38." @default.
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- W2022893491 date "2009-12-10" @default.
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- W2022893491 title "Abstract C38: Immunosuppression by indoleamine 2,3‐dioxygenase in mesenchymal stem cells derived from adult human tissues" @default.
- W2022893491 doi "https://doi.org/10.1158/1535-7163.targ-09-c38" @default.
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