FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022894433> ?p ?o ?g. }

• W2022894433 endingPage "704" @default.
• W2022894433 startingPage "697" @default.
• W2022894433 abstract "Considerable research is aimed at determining the mechanisms by which hormone-refractory prostate cancer develops. In an effort to assist in the understanding of recurrent prostate cancer and the cellular processes that mediate this disease, a mathematical model is presented that describes both the pretreatment growth and the posttherapy relapse of human prostate cancer xenografts. Our goal is to evaluate the interplay between the multiple mechanisms that have been postulated as causes of androgen-independent relapse. Simulations of the model show that molecular events that render the androgen receptor irrelevant to disease progression, such as upregulation of BCL2, can result in relapse after androgen deprivation therapy. However, decreased apoptosis of androgenindependent cells alone overestimates the effects of hormone therapy when compared to experimental data. When decreased apoptosis is combined with continual androgen receptor activation, the posttherapy growth dynamics are in excellent correlation with experimental observations of the growth of LuCaP xenografts. Furthermore, the mathematical model predicts that upregulation of the androgen receptor, together with its increased activation, is alone sufficient to result in the androgen-independent growth of LNCaP xenografts. Recent experimental studies that suggest that the posttherapy increase in and continual activation of the androgen receptor are common and crucial features of recurrent prostate cancer provide validation of the model predictions. This approach provides a framework for using mathematical techniques to study novel therapeutic strategies aimed at controlling this disease." @default.
• W2022894433 created "2016-06-24" @default.
• W2022894433 creator A5051945003 @default.
• W2022894433 date "2004-11-01" @default.
• W2022894433 modified "2023-09-26" @default.
• W2022894433 title "A Mathematical Investigation of the Multiple Pathways to Recurrent Prostate Cancer: Comparison with Experimental Data" @default.
• W2022894433 cites W1523568656 @default.
• W2022894433 cites W1973299472 @default.
• W2022894433 cites W1995115168 @default.
• W2022894433 cites W2002570890 @default.
• W2022894433 cites W2003955264 @default.
• W2022894433 cites W2013933084 @default.
• W2022894433 cites W2035872652 @default.
• W2022894433 cites W2062440930 @default.
• W2022894433 cites W2076445987 @default.
• W2022894433 cites W2076868976 @default.
• W2022894433 cites W2084952798 @default.
• W2022894433 cites W2088292624 @default.
• W2022894433 cites W2091931537 @default.
• W2022894433 cites W2099876620 @default.
• W2022894433 cites W2102090981 @default.
• W2022894433 cites W2102821757 @default.
• W2022894433 cites W2103576304 @default.
• W2022894433 cites W2117325725 @default.
• W2022894433 cites W2122947245 @default.
• W2022894433 cites W2123927174 @default.
• W2022894433 cites W2132424867 @default.
• W2022894433 cites W2138593266 @default.
• W2022894433 cites W4232547688 @default.
• W2022894433 cites W4242568052 @default.
• W2022894433 doi "https://doi.org/10.1593/neo.04259" @default.
• W2022894433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1531673" @default.
• W2022894433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15720795" @default.
• W2022894433 hasPublicationYear "2004" @default.
• W2022894433 type Work @default.
• W2022894433 sameAs 2022894433 @default.
• W2022894433 citedByCount "58" @default.
• W2022894433 countsByYear W20228944332012 @default.
• W2022894433 countsByYear W20228944332013 @default.
• W2022894433 countsByYear W20228944332014 @default.
• W2022894433 countsByYear W20228944332015 @default.
• W2022894433 countsByYear W20228944332016 @default.
• W2022894433 countsByYear W20228944332017 @default.
• W2022894433 countsByYear W20228944332018 @default.
• W2022894433 countsByYear W20228944332019 @default.
• W2022894433 countsByYear W20228944332020 @default.
• W2022894433 countsByYear W20228944332021 @default.
• W2022894433 countsByYear W20228944332023 @default.
• W2022894433 crossrefType "journal-article" @default.
• W2022894433 hasAuthorship W2022894433A5051945003 @default.
• W2022894433 hasBestOaLocation W20228944331 @default.
• W2022894433 hasConcept C104317684 @default.
• W2022894433 hasConcept C121608353 @default.
• W2022894433 hasConcept C126322002 @default.
• W2022894433 hasConcept C127561419 @default.
• W2022894433 hasConcept C134018914 @default.
• W2022894433 hasConcept C143998085 @default.
• W2022894433 hasConcept C2776235491 @default.
• W2022894433 hasConcept C2777899217 @default.
• W2022894433 hasConcept C2777911890 @default.
• W2022894433 hasConcept C2779723316 @default.
• W2022894433 hasConcept C2780192828 @default.
• W2022894433 hasConcept C502942594 @default.
• W2022894433 hasConcept C55493867 @default.
• W2022894433 hasConcept C61367390 @default.
• W2022894433 hasConcept C71315377 @default.
• W2022894433 hasConcept C71924100 @default.
• W2022894433 hasConcept C86803240 @default.
• W2022894433 hasConceptScore W2022894433C104317684 @default.
• W2022894433 hasConceptScore W2022894433C121608353 @default.
• W2022894433 hasConceptScore W2022894433C126322002 @default.
• W2022894433 hasConceptScore W2022894433C127561419 @default.
• W2022894433 hasConceptScore W2022894433C134018914 @default.
• W2022894433 hasConceptScore W2022894433C143998085 @default.
• W2022894433 hasConceptScore W2022894433C2776235491 @default.
• W2022894433 hasConceptScore W2022894433C2777899217 @default.
• W2022894433 hasConceptScore W2022894433C2777911890 @default.
• W2022894433 hasConceptScore W2022894433C2779723316 @default.
• W2022894433 hasConceptScore W2022894433C2780192828 @default.
• W2022894433 hasConceptScore W2022894433C502942594 @default.
• W2022894433 hasConceptScore W2022894433C55493867 @default.
• W2022894433 hasConceptScore W2022894433C61367390 @default.
• W2022894433 hasConceptScore W2022894433C71315377 @default.
• W2022894433 hasConceptScore W2022894433C71924100 @default.
• W2022894433 hasConceptScore W2022894433C86803240 @default.
• W2022894433 hasIssue "6" @default.
• W2022894433 hasLocation W20228944331 @default.
• W2022894433 hasLocation W20228944332 @default.
• W2022894433 hasLocation W20228944333 @default.
• W2022894433 hasLocation W20228944334 @default.
• W2022894433 hasOpenAccess W2022894433 @default.
• W2022894433 hasPrimaryLocation W20228944331 @default.
• W2022894433 hasRelatedWork W1511886058 @default.
• W2022894433 hasRelatedWork W1606103292 @default.
• W2022894433 hasRelatedWork W1970062306 @default.
• W2022894433 hasRelatedWork W2012049790 @default.
• W2022894433 hasRelatedWork W2082788526 @default.
• W2022894433 hasRelatedWork W2192795899 @default.

• next