FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022894788> ?p ?o ?g. }

• W2022894788 endingPage "81" @default.
• W2022894788 startingPage "74" @default.
• W2022894788 abstract "Cisplatin, a cancer chemotherapy agent, like many toxins, produces emesis and nausea. Abdominal vagotomy, or treatment with 5-HT3 receptor antagonists, blocks cisplatin-induced emesis, which suggests that it produces (albeit indirectly) activation of 5-HT3 receptors on vagal afferent fibers. Cisplatin induces a large release of intestinal 5-hydroxytryptamine (5-HT) that enters the hepatic portal vein, which may activate vagal afferent fibers in the portal vein or liver to induce emesis or other side effects of treatment (e.g., reduced food intake). This study was conducted to assess the effects of cisplatin on gastrointestinal and portal vein/liver vagal afferent fibers by recording the neurophysiological responses of the common hepatic branch (CHB) of the vagus in the rat. The CHB contains vagal afferent fibers that innervate the gastrointestinal (GI) tract, portal vein, and liver. Cisplatin (10 mg/kg; jugular vein, j.v.) produced an increase in multi-unit CHB activity and this effect was blocked by a 5-HT3-receptor antagonist (Y-25130, 0.8 mg, j.v.). Cutting the gastroduodenal branch (GDB), a sub-branch of the CHB that contains GI afferent fibers, resulted in a complete suppression of the multi-unit CHB discharge produced by cisplatin treatment. Single units that were cisplatin sensitive had their activity reduced by either 5-HT3 receptor antagonist treatment or cutting the GDB. Conversely, cisplatin insensitive units were not affected by 5-HT3-antagonism or GDB ablation. The present results indicate that cisplatin activates GI vagal afferent fibers via 5-HT3 receptors but does not affect portal vein/liver vagal afferent fibers, which indicates that intestinal but not hepatic afferent fibers are involved in the toxic effects of cisplatin." @default.
• W2022894788 created "2016-06-24" @default.
• W2022894788 creator A5048442853 @default.
• W2022894788 creator A5051550492 @default.
• W2022894788 creator A5081947723 @default.
• W2022894788 creator A5084066999 @default.
• W2022894788 date "2004-09-01" @default.
• W2022894788 modified "2023-10-18" @default.
• W2022894788 title "Differential effects on gastrointestinal and hepatic vagal afferent fibers in the rat by the anti-cancer agent cisplatin" @default.
• W2022894788 cites W1876036557 @default.
• W2022894788 cites W1968823723 @default.
• W2022894788 cites W1973001367 @default.
• W2022894788 cites W1987066793 @default.
• W2022894788 cites W1987248916 @default.
• W2022894788 cites W2007376132 @default.
• W2022894788 cites W2007440492 @default.
• W2022894788 cites W2015463371 @default.
• W2022894788 cites W2026420003 @default.
• W2022894788 cites W2028385335 @default.
• W2022894788 cites W2046970316 @default.
• W2022894788 cites W2047479351 @default.
• W2022894788 cites W2047638106 @default.
• W2022894788 cites W2061791637 @default.
• W2022894788 cites W2067958046 @default.
• W2022894788 cites W2069024019 @default.
• W2022894788 cites W2069284352 @default.
• W2022894788 cites W2088358644 @default.
• W2022894788 cites W2091158770 @default.
• W2022894788 cites W2114666737 @default.
• W2022894788 cites W2141093120 @default.
• W2022894788 cites W2143952462 @default.
• W2022894788 cites W2298570421 @default.
• W2022894788 cites W2324882224 @default.
• W2022894788 doi "https://doi.org/10.1016/j.autneu.2004.08.011" @default.
• W2022894788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15507408" @default.
• W2022894788 hasPublicationYear "2004" @default.
• W2022894788 type Work @default.
• W2022894788 sameAs 2022894788 @default.
• W2022894788 citedByCount "44" @default.
• W2022894788 countsByYear W20228947882013 @default.
• W2022894788 countsByYear W20228947882014 @default.
• W2022894788 countsByYear W20228947882015 @default.
• W2022894788 countsByYear W20228947882016 @default.
• W2022894788 countsByYear W20228947882017 @default.
• W2022894788 countsByYear W20228947882018 @default.
• W2022894788 countsByYear W20228947882020 @default.
• W2022894788 countsByYear W20228947882021 @default.
• W2022894788 countsByYear W20228947882022 @default.
• W2022894788 countsByYear W20228947882023 @default.
• W2022894788 crossrefType "journal-article" @default.
• W2022894788 hasAuthorship W2022894788A5048442853 @default.
• W2022894788 hasAuthorship W2022894788A5051550492 @default.
• W2022894788 hasAuthorship W2022894788A5081947723 @default.
• W2022894788 hasAuthorship W2022894788A5084066999 @default.
• W2022894788 hasConcept C126322002 @default.
• W2022894788 hasConcept C134018914 @default.
• W2022894788 hasConcept C170493617 @default.
• W2022894788 hasConcept C185592680 @default.
• W2022894788 hasConcept C24998067 @default.
• W2022894788 hasConcept C2776694085 @default.
• W2022894788 hasConcept C2776885963 @default.
• W2022894788 hasConcept C2777452722 @default.
• W2022894788 hasConcept C2778122271 @default.
• W2022894788 hasConcept C2778239845 @default.
• W2022894788 hasConcept C2780884295 @default.
• W2022894788 hasConcept C2781404750 @default.
• W2022894788 hasConcept C71924100 @default.
• W2022894788 hasConcept C90924648 @default.
• W2022894788 hasConcept C98274493 @default.
• W2022894788 hasConceptScore W2022894788C126322002 @default.
• W2022894788 hasConceptScore W2022894788C134018914 @default.
• W2022894788 hasConceptScore W2022894788C170493617 @default.
• W2022894788 hasConceptScore W2022894788C185592680 @default.
• W2022894788 hasConceptScore W2022894788C24998067 @default.
• W2022894788 hasConceptScore W2022894788C2776694085 @default.
• W2022894788 hasConceptScore W2022894788C2776885963 @default.
• W2022894788 hasConceptScore W2022894788C2777452722 @default.
• W2022894788 hasConceptScore W2022894788C2778122271 @default.
• W2022894788 hasConceptScore W2022894788C2778239845 @default.
• W2022894788 hasConceptScore W2022894788C2780884295 @default.
• W2022894788 hasConceptScore W2022894788C2781404750 @default.
• W2022894788 hasConceptScore W2022894788C71924100 @default.
• W2022894788 hasConceptScore W2022894788C90924648 @default.
• W2022894788 hasConceptScore W2022894788C98274493 @default.
• W2022894788 hasIssue "1-2" @default.
• W2022894788 hasLocation W20228947881 @default.
• W2022894788 hasLocation W20228947882 @default.
• W2022894788 hasOpenAccess W2022894788 @default.
• W2022894788 hasPrimaryLocation W20228947881 @default.
• W2022894788 hasRelatedWork W1996846474 @default.
• W2022894788 hasRelatedWork W2018368842 @default.
• W2022894788 hasRelatedWork W2029100518 @default.
• W2022894788 hasRelatedWork W2033472167 @default.
• W2022894788 hasRelatedWork W2034583712 @default.
• W2022894788 hasRelatedWork W2063619316 @default.
• W2022894788 hasRelatedWork W2067558789 @default.
• W2022894788 hasRelatedWork W2169225653 @default.
• W2022894788 hasRelatedWork W2414846389 @default.

• next