Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022896275> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2022896275 endingPage "64" @default.
- W2022896275 startingPage "59" @default.
- W2022896275 abstract "Abstract The aim of the present study is to evaluate the measurement of midnight salivary cortisol as a method of screening for Cushing’s syndrome (CS). Here we tested the performance of a highly sensitive electrochemiluminescence immunoassay (ECLIA) for midnight salivary cortisol measurement in an extensive clinical study (n=104). Three groups were investigated: 30 patients with CS, 34 with obesity and 40 healthy normal weight controls. All of them collected saliva samples at 24:00 h and urine samples over the same day (24 hour period). An electrochemiluminescence immunoassay was used to measure salivary cortisol. Mean midnight salivary cortisol in healthy volunteers, obese patients and patients with CS was 8.33 ± 3.62, 8.13 ± 4.47 and 33.11 ± 21.68 nmol/l, respectively. No significant difference was found between midnight salivary cortisol in healthy and obese subjects (P>0.05). In contrast, salivary cortisol at midnight was significantly higher in patients with CS (P<0.001) as compared to both other groups. The cut-off point of 14.2 nmol/l yielded a sensitivity of 93.3% and a specificity of 94.2% (AUCROC=0.984 ± 0.01(0.965-1.000). A strong positive correlation between midnight salivary cortisol and urinary free cortisol has been found in the CS group (r=0.686, P<0.0001). Our results demonstrate that measurement of midnight salivary cortisol could be successfully used as a first-line screening method for CS. Our data approve ECLIA as a simple, reliable and timesaving method for the assessment of salivary cortisol. Automated measurement of midnight salivary cortisol by ECLIA would facilitate the routine practice in the screening for CS." @default.
- W2022896275 created "2016-06-24" @default.
- W2022896275 creator A5046393139 @default.
- W2022896275 creator A5066720616 @default.
- W2022896275 creator A5075515616 @default.
- W2022896275 date "2009-03-01" @default.
- W2022896275 modified "2023-10-11" @default.
- W2022896275 title "Midnight salivary cortisol, measured by highly sensitive electrochemiluminescence immunoassay, for the diagnosis of Cushing’s syndrome" @default.
- W2022896275 cites W1941083590 @default.
- W2022896275 cites W1976461290 @default.
- W2022896275 cites W1981998610 @default.
- W2022896275 cites W1995316958 @default.
- W2022896275 cites W2015250786 @default.
- W2022896275 cites W2023934963 @default.
- W2022896275 cites W2031616938 @default.
- W2022896275 cites W2061395344 @default.
- W2022896275 cites W2061962280 @default.
- W2022896275 cites W2062000903 @default.
- W2022896275 cites W2089490142 @default.
- W2022896275 cites W2099145455 @default.
- W2022896275 cites W2122446677 @default.
- W2022896275 cites W2131474586 @default.
- W2022896275 cites W2141061065 @default.
- W2022896275 cites W2160362883 @default.
- W2022896275 doi "https://doi.org/10.2478/s11536-009-0004-y" @default.
- W2022896275 hasPublicationYear "2009" @default.
- W2022896275 type Work @default.
- W2022896275 sameAs 2022896275 @default.
- W2022896275 citedByCount "20" @default.
- W2022896275 countsByYear W20228962752012 @default.
- W2022896275 countsByYear W20228962752013 @default.
- W2022896275 countsByYear W20228962752014 @default.
- W2022896275 countsByYear W20228962752017 @default.
- W2022896275 countsByYear W20228962752019 @default.
- W2022896275 countsByYear W20228962752020 @default.
- W2022896275 countsByYear W20228962752023 @default.
- W2022896275 crossrefType "journal-article" @default.
- W2022896275 hasAuthorship W2022896275A5046393139 @default.
- W2022896275 hasAuthorship W2022896275A5066720616 @default.
- W2022896275 hasAuthorship W2022896275A5075515616 @default.
- W2022896275 hasBestOaLocation W20228962751 @default.
- W2022896275 hasConcept C121332964 @default.
- W2022896275 hasConcept C126322002 @default.
- W2022896275 hasConcept C1276947 @default.
- W2022896275 hasConcept C134018914 @default.
- W2022896275 hasConcept C159654299 @default.
- W2022896275 hasConcept C203014093 @default.
- W2022896275 hasConcept C25188466 @default.
- W2022896275 hasConcept C2780026642 @default.
- W2022896275 hasConcept C2780420688 @default.
- W2022896275 hasConcept C504460877 @default.
- W2022896275 hasConcept C71924100 @default.
- W2022896275 hasConceptScore W2022896275C121332964 @default.
- W2022896275 hasConceptScore W2022896275C126322002 @default.
- W2022896275 hasConceptScore W2022896275C1276947 @default.
- W2022896275 hasConceptScore W2022896275C134018914 @default.
- W2022896275 hasConceptScore W2022896275C159654299 @default.
- W2022896275 hasConceptScore W2022896275C203014093 @default.
- W2022896275 hasConceptScore W2022896275C25188466 @default.
- W2022896275 hasConceptScore W2022896275C2780026642 @default.
- W2022896275 hasConceptScore W2022896275C2780420688 @default.
- W2022896275 hasConceptScore W2022896275C504460877 @default.
- W2022896275 hasConceptScore W2022896275C71924100 @default.
- W2022896275 hasIssue "1" @default.
- W2022896275 hasLocation W20228962751 @default.
- W2022896275 hasLocation W20228962752 @default.
- W2022896275 hasOpenAccess W2022896275 @default.
- W2022896275 hasPrimaryLocation W20228962751 @default.
- W2022896275 hasRelatedWork W2010498657 @default.
- W2022896275 hasRelatedWork W2036414402 @default.
- W2022896275 hasRelatedWork W2355850862 @default.
- W2022896275 hasRelatedWork W2389240028 @default.
- W2022896275 hasRelatedWork W2748952813 @default.
- W2022896275 hasRelatedWork W4245861830 @default.
- W2022896275 hasRelatedWork W495203753 @default.
- W2022896275 hasRelatedWork W564328771 @default.
- W2022896275 hasRelatedWork W599365682 @default.
- W2022896275 hasRelatedWork W2241230381 @default.
- W2022896275 hasVolume "4" @default.
- W2022896275 isParatext "false" @default.
- W2022896275 isRetracted "false" @default.
- W2022896275 magId "2022896275" @default.
- W2022896275 workType "article" @default.