FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022896439> ?p ?o ?g. }

• W2022896439 endingPage "2591" @default.
• W2022896439 startingPage "2581" @default.
• W2022896439 abstract "Estrogen is an essential hormone for the LH surge and ovulation. The primary source of estrogen is from ovarian granulosa cells and in rats, estrogen, in turn, increases granulosa cell number and enhances FSH-stimulated gene expression in these cells. Thus, rat granulosa cells both respond to and synthesize estrogen. To further elucidate the mechanisms mediating the actions of estrogen in granulosa cells, we have identified and characterized the estrogen receptor-beta (ER-beta) subtype in rodent granulosa cells. ER-beta protein was localized to the nuclei of rat granulosa cells in preantral and antral follicles by immunocytochemistry, coincident with the location of ER-beta messenger RNA (mRNA). Immunoprecipitation and Western blot analysis using ER-beta specific antisera demonstrated a protein of approximately 60 kDa in granulosa cells prepared from PMSG-primed immature mice and estrogen-treated immature rats. Extracts from granulosa cells specifically bound an estrogen response element and the complex was recognized by antisera to ER-beta. A synthetic steroid estrogen radioligand, [125I]-17alpha-iodovinyl-11beta-methoxyestradiol ([125I]-VME2), bound to cytosolic granulosa cell preparations with high affinity (estimated K(D) value of 401 +/- 83 pM, and Bmax value of 102 +/- 9 fmol/mg protein). ER-beta protein levels rapidly declined following hCG treatment consistent with the reported decrease in binding activity and ER-beta mRNA levels by high levels of gonadotropins. Overall, we have demonstrated that 1) ER-beta protein is the dominant estrogen receptor subtype present in rodent granulosa cells, 2) this receptor is functional, and 3) it is regulated by ovulatory doses of gonadotropins. Thus, ER-beta is likely to be a mediator of estrogen action in rodent granulosa cells during follicular development." @default.
• W2022896439 created "2016-06-24" @default.
• W2022896439 creator A5021718119 @default.
• W2022896439 creator A5024171875 @default.
• W2022896439 creator A5039280689 @default.
• W2022896439 creator A5049266502 @default.
• W2022896439 creator A5063533512 @default.
• W2022896439 creator A5075302004 @default.
• W2022896439 creator A5081301721 @default.
• W2022896439 creator A5085743851 @default.
• W2022896439 date "1999-06-01" @default.
• W2022896439 modified "2023-10-16" @default.
• W2022896439 title "Expression of Estrogen Receptor-β Protein in Rodent Ovary" @default.
• W2022896439 cites W1507202425 @default.
• W2022896439 cites W195223388 @default.
• W2022896439 cites W1974572724 @default.
• W2022896439 cites W1976187655 @default.
• W2022896439 cites W1983088403 @default.
• W2022896439 cites W1984151469 @default.
• W2022896439 cites W1987324195 @default.
• W2022896439 cites W1988611170 @default.
• W2022896439 cites W1990215840 @default.
• W2022896439 cites W1993500310 @default.
• W2022896439 cites W2009286291 @default.
• W2022896439 cites W2012209524 @default.
• W2022896439 cites W2012425172 @default.
• W2022896439 cites W2015611519 @default.
• W2022896439 cites W2015816296 @default.
• W2022896439 cites W2016669417 @default.
• W2022896439 cites W2019455802 @default.
• W2022896439 cites W2020970433 @default.
• W2022896439 cites W2026207114 @default.
• W2022896439 cites W2038688425 @default.
• W2022896439 cites W2068076267 @default.
• W2022896439 cites W2068673201 @default.
• W2022896439 cites W2068845386 @default.
• W2022896439 cites W2070907292 @default.
• W2022896439 cites W2073353512 @default.
• W2022896439 cites W2073883348 @default.
• W2022896439 cites W2078444442 @default.
• W2022896439 cites W2089542555 @default.
• W2022896439 cites W2098332112 @default.
• W2022896439 cites W2104594573 @default.
• W2022896439 cites W2109102732 @default.
• W2022896439 cites W2118506472 @default.
• W2022896439 cites W2124965472 @default.
• W2022896439 cites W2128242453 @default.
• W2022896439 cites W2131391777 @default.
• W2022896439 cites W2141269411 @default.
• W2022896439 cites W2149573140 @default.
• W2022896439 cites W2151071712 @default.
• W2022896439 cites W2161623422 @default.
• W2022896439 cites W2165556073 @default.
• W2022896439 cites W2321613759 @default.
• W2022896439 cites W2407987762 @default.
• W2022896439 cites W4212936275 @default.
• W2022896439 doi "https://doi.org/10.1210/endo.140.6.6928" @default.
• W2022896439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10342845" @default.
• W2022896439 hasPublicationYear "1999" @default.
• W2022896439 type Work @default.
• W2022896439 sameAs 2022896439 @default.
• W2022896439 citedByCount "106" @default.
• W2022896439 countsByYear W20228964392012 @default.
• W2022896439 countsByYear W20228964392014 @default.
• W2022896439 countsByYear W20228964392015 @default.
• W2022896439 countsByYear W20228964392016 @default.
• W2022896439 countsByYear W20228964392017 @default.
• W2022896439 countsByYear W20228964392018 @default.
• W2022896439 countsByYear W20228964392019 @default.
• W2022896439 countsByYear W20228964392022 @default.
• W2022896439 countsByYear W20228964392023 @default.
• W2022896439 crossrefType "journal-article" @default.
• W2022896439 hasAuthorship W2022896439A5021718119 @default.
• W2022896439 hasAuthorship W2022896439A5024171875 @default.
• W2022896439 hasAuthorship W2022896439A5039280689 @default.
• W2022896439 hasAuthorship W2022896439A5049266502 @default.
• W2022896439 hasAuthorship W2022896439A5063533512 @default.
• W2022896439 hasAuthorship W2022896439A5075302004 @default.
• W2022896439 hasAuthorship W2022896439A5081301721 @default.
• W2022896439 hasAuthorship W2022896439A5085743851 @default.
• W2022896439 hasBestOaLocation W20228964391 @default.
• W2022896439 hasConcept C121608353 @default.
• W2022896439 hasConcept C126322002 @default.
• W2022896439 hasConcept C134018914 @default.
• W2022896439 hasConcept C172313692 @default.
• W2022896439 hasConcept C2777164284 @default.
• W2022896439 hasConcept C2777203538 @default.
• W2022896439 hasConcept C2778324911 @default.
• W2022896439 hasConcept C530470458 @default.
• W2022896439 hasConcept C71924100 @default.
• W2022896439 hasConcept C84606932 @default.
• W2022896439 hasConcept C86803240 @default.
• W2022896439 hasConcept C96307122 @default.
• W2022896439 hasConceptScore W2022896439C121608353 @default.
• W2022896439 hasConceptScore W2022896439C126322002 @default.
• W2022896439 hasConceptScore W2022896439C134018914 @default.
• W2022896439 hasConceptScore W2022896439C172313692 @default.
• W2022896439 hasConceptScore W2022896439C2777164284 @default.

• next