FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022897246> ?p ?o ?g. }

• W2022897246 endingPage "138" @default.
• W2022897246 startingPage "101" @default.
• W2022897246 abstract "Hsp90 has become the target of intensive investigation, as inhibition of its function has the ability to simultaneously incapacitate proteins that function in pathways that represent the six hallmarks of cancer. While a number of Hsp90 inhibitors have made it into clinical trials, a number of short-comings have been noted, such that the search continues for novel Hsp90 inhibitors with superior pharmacological properties. To identify new potential Hsp90 inhibitors, we have utilized a high-throughput assay based on measuring Hsp90-dependent refolding of thermally denatured luciferase to screen natural compound libraries. Over 4,000 compounds were screen with over 100 hits. Data mining of the literature indicated that 51 compounds had physiological effects that Hsp90 inhibitors also exhibit, and/or the ability to downregulate the expression levels of Hsp90-dependent proteins. Of these 51 compounds, seven were previously characterized as Hsp90 inhibitors. Four compounds, anthothecol, garcinol, piplartine, and rottlerin, were further characterized, and the ability of these compounds to inhibit the refolding of luciferase, and reduce the rate of growth of MCF7 breast cancer cells, correlated with their ability to suppress the Hsp90-dependent maturation of the heme-regulated eIF2α kinase, and deplete cultured cells of Hsp90-dependent client proteins. Thus, this screen has identified an additional 44 compounds with known beneficial pharmacological properties, but with unknown mechanisms of action as possible new inhibitors of the Hsp90 chaperone machine." @default.
• W2022897246 created "2016-06-24" @default.
• W2022897246 creator A5003176683 @default.
• W2022897246 creator A5018232466 @default.
• W2022897246 creator A5035181974 @default.
• W2022897246 creator A5043830739 @default.
• W2022897246 creator A5054628403 @default.
• W2022897246 creator A5055374036 @default.
• W2022897246 creator A5062921807 @default.
• W2022897246 date "2014-02-10" @default.
• W2022897246 modified "2023-09-26" @default.
• W2022897246 title "High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors" @default.
• W2022897246 cites W1484788901 @default.
• W2022897246 cites W1553060509 @default.
• W2022897246 cites W1553826095 @default.
• W2022897246 cites W172101602 @default.
• W2022897246 cites W1911262314 @default.
• W2022897246 cites W1932251091 @default.
• W2022897246 cites W1952221220 @default.
• W2022897246 cites W1964578526 @default.
• W2022897246 cites W1965596274 @default.
• W2022897246 cites W1966580582 @default.
• W2022897246 cites W1967172808 @default.
• W2022897246 cites W1967308926 @default.
• W2022897246 cites W1968023849 @default.
• W2022897246 cites W1971384009 @default.
• W2022897246 cites W1975502282 @default.
• W2022897246 cites W1976026427 @default.
• W2022897246 cites W1976216345 @default.
• W2022897246 cites W1976419927 @default.
• W2022897246 cites W1977703905 @default.
• W2022897246 cites W1979309539 @default.
• W2022897246 cites W1980236741 @default.
• W2022897246 cites W1981591706 @default.
• W2022897246 cites W1984573249 @default.
• W2022897246 cites W1984971978 @default.
• W2022897246 cites W1986631420 @default.
• W2022897246 cites W1986787107 @default.
• W2022897246 cites W1988031115 @default.
• W2022897246 cites W1988288367 @default.
• W2022897246 cites W1988963406 @default.
• W2022897246 cites W1989600727 @default.
• W2022897246 cites W1991320792 @default.
• W2022897246 cites W1991742136 @default.
• W2022897246 cites W1992716708 @default.
• W2022897246 cites W1993271672 @default.
• W2022897246 cites W1994232874 @default.
• W2022897246 cites W1995351861 @default.
• W2022897246 cites W1997362033 @default.
• W2022897246 cites W1997473479 @default.
• W2022897246 cites W1999306559 @default.
• W2022897246 cites W1999940180 @default.
• W2022897246 cites W2000929246 @default.
• W2022897246 cites W2001232700 @default.
• W2022897246 cites W2002449811 @default.
• W2022897246 cites W2002823741 @default.
• W2022897246 cites W2004952937 @default.
• W2022897246 cites W2006685024 @default.
• W2022897246 cites W2008450697 @default.
• W2022897246 cites W2008672350 @default.
• W2022897246 cites W2010102069 @default.
• W2022897246 cites W2010809759 @default.
• W2022897246 cites W2012476423 @default.
• W2022897246 cites W2013888645 @default.
• W2022897246 cites W2014400440 @default.
• W2022897246 cites W2015638581 @default.
• W2022897246 cites W2016063414 @default.
• W2022897246 cites W2017127543 @default.
• W2022897246 cites W2018716591 @default.
• W2022897246 cites W2021071651 @default.
• W2022897246 cites W2021846466 @default.
• W2022897246 cites W2022560888 @default.
• W2022897246 cites W2025838053 @default.
• W2022897246 cites W2030223903 @default.
• W2022897246 cites W2031613073 @default.
• W2022897246 cites W2032255930 @default.
• W2022897246 cites W2032656071 @default.
• W2022897246 cites W2033159358 @default.
• W2022897246 cites W2034930480 @default.
• W2022897246 cites W2035019915 @default.
• W2022897246 cites W2035129824 @default.
• W2022897246 cites W2035931564 @default.
• W2022897246 cites W2036866132 @default.
• W2022897246 cites W2037393542 @default.
• W2022897246 cites W2038275783 @default.
• W2022897246 cites W2039965018 @default.
• W2022897246 cites W2042170514 @default.
• W2022897246 cites W2042699875 @default.
• W2022897246 cites W2043509228 @default.
• W2022897246 cites W2043930391 @default.
• W2022897246 cites W2045557409 @default.
• W2022897246 cites W2046683220 @default.
• W2022897246 cites W2046822015 @default.
• W2022897246 cites W2048101518 @default.
• W2022897246 cites W2049321385 @default.
• W2022897246 cites W2049606241 @default.
• W2022897246 cites W2049797948 @default.
• W2022897246 cites W2050574267 @default.

• next