Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022897778> ?p ?o ?g. }
- W2022897778 endingPage "11" @default.
- W2022897778 startingPage "4" @default.
- W2022897778 abstract "Constitutive activation of STAT3 (signal transducer and activator of transcription) has been reported in several primary cancers and tumor cell lines where it induces cell transformation through a combined inhibition of apoptosis and cell-cycle activation. Several studies have suggested that STAT3 prevents cell-cycle arrest and cell death through upregulation of survival proteins and downregulation of tumor suppressors. As a consequence of anti-apoptotic and proliferative lesions, we propose that this oncogenic pathway is also involved in intrinsic drug resistance and that STAT3-expressing tumors are resistant to chemotherapeutic agents. If this hypothesis is correct, the detection of the activated form of this protein should help to define subsets of tumors that fail to respond to chemotherapy. Furthermore, interfering with the STAT3 oncogenic pathway might restore the sensitivity to anticancer drugs." @default.
- W2022897778 created "2016-06-24" @default.
- W2022897778 creator A5006208805 @default.
- W2022897778 creator A5031705295 @default.
- W2022897778 creator A5039266781 @default.
- W2022897778 creator A5045241718 @default.
- W2022897778 creator A5056083434 @default.
- W2022897778 creator A5066325833 @default.
- W2022897778 date "2007-01-01" @default.
- W2022897778 modified "2023-10-08" @default.
- W2022897778 title "The STAT3 oncogene as a predictive marker of drug resistance" @default.
- W2022897778 cites W1485459479 @default.
- W2022897778 cites W1545398558 @default.
- W2022897778 cites W1548640328 @default.
- W2022897778 cites W1560780012 @default.
- W2022897778 cites W1593569677 @default.
- W2022897778 cites W1595815978 @default.
- W2022897778 cites W1604468403 @default.
- W2022897778 cites W1965009601 @default.
- W2022897778 cites W1965425054 @default.
- W2022897778 cites W1968631842 @default.
- W2022897778 cites W1971599842 @default.
- W2022897778 cites W1973732108 @default.
- W2022897778 cites W1973995026 @default.
- W2022897778 cites W1977635166 @default.
- W2022897778 cites W1979785616 @default.
- W2022897778 cites W1981006523 @default.
- W2022897778 cites W1981433220 @default.
- W2022897778 cites W1982395176 @default.
- W2022897778 cites W1985995289 @default.
- W2022897778 cites W1986014209 @default.
- W2022897778 cites W1990161819 @default.
- W2022897778 cites W1990578478 @default.
- W2022897778 cites W2004527202 @default.
- W2022897778 cites W2007739717 @default.
- W2022897778 cites W2011717936 @default.
- W2022897778 cites W2012076841 @default.
- W2022897778 cites W2014518336 @default.
- W2022897778 cites W2019491391 @default.
- W2022897778 cites W2019845267 @default.
- W2022897778 cites W2020329784 @default.
- W2022897778 cites W2021860656 @default.
- W2022897778 cites W2027844562 @default.
- W2022897778 cites W2028210102 @default.
- W2022897778 cites W2032471037 @default.
- W2022897778 cites W2033860910 @default.
- W2022897778 cites W2034269086 @default.
- W2022897778 cites W2035107532 @default.
- W2022897778 cites W2046158839 @default.
- W2022897778 cites W2048292316 @default.
- W2022897778 cites W2049548558 @default.
- W2022897778 cites W2051821952 @default.
- W2022897778 cites W2063382981 @default.
- W2022897778 cites W2064076939 @default.
- W2022897778 cites W2065086280 @default.
- W2022897778 cites W2067117191 @default.
- W2022897778 cites W2068133168 @default.
- W2022897778 cites W2074356752 @default.
- W2022897778 cites W2075165800 @default.
- W2022897778 cites W2076411120 @default.
- W2022897778 cites W2080769506 @default.
- W2022897778 cites W2097050286 @default.
- W2022897778 cites W2106105700 @default.
- W2022897778 cites W2107398189 @default.
- W2022897778 cites W2114445658 @default.
- W2022897778 cites W2118310862 @default.
- W2022897778 cites W2119239003 @default.
- W2022897778 cites W2119528486 @default.
- W2022897778 cites W2124614845 @default.
- W2022897778 cites W2125933228 @default.
- W2022897778 cites W2129821701 @default.
- W2022897778 cites W2130307435 @default.
- W2022897778 cites W2130594876 @default.
- W2022897778 cites W2131152510 @default.
- W2022897778 cites W2135119164 @default.
- W2022897778 cites W2141817193 @default.
- W2022897778 cites W2143705626 @default.
- W2022897778 cites W2153833981 @default.
- W2022897778 cites W2159118796 @default.
- W2022897778 cites W2163046152 @default.
- W2022897778 cites W2167065253 @default.
- W2022897778 cites W2170090299 @default.
- W2022897778 cites W2171282302 @default.
- W2022897778 cites W2184975107 @default.
- W2022897778 cites W2322555451 @default.
- W2022897778 cites W4229746880 @default.
- W2022897778 cites W4237398626 @default.
- W2022897778 cites W4239762160 @default.
- W2022897778 cites W4245093707 @default.
- W2022897778 cites W4246727707 @default.
- W2022897778 cites W4249713142 @default.
- W2022897778 doi "https://doi.org/10.1016/j.molmed.2006.11.001" @default.
- W2022897778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17118707" @default.
- W2022897778 hasPublicationYear "2007" @default.
- W2022897778 type Work @default.
- W2022897778 sameAs 2022897778 @default.
- W2022897778 citedByCount "106" @default.
- W2022897778 countsByYear W20228977782012 @default.