FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022898802> ?p ?o ?g. }

• W2022898802 endingPage "1176" @default.
• W2022898802 startingPage "1173" @default.
• W2022898802 abstract "Crohn’s disease and ulcerative colitis are chronic, immune-mediated inflammatory diseases of the gastrointestinal tract, affecting up to 0.4% of the population in Western countries.1 They are considered complex multifactorial polygenic diseases. While dramatic progress has been made in deciphering the genetic architecture of Crohn’s disease, ulcerative colitis was somewhat left behind, with virtually no relevant studies published until very recently. Although both disorders are considered to belong to the same spectrum of pathologies, the first gene clearly associated with Crohn’s disease ( CARD-15 )2 3 did not seem to predispose to ulcerative colitis in any cohort in which it was tested. This finding highlighted some pathogenic differences between the two diseases, and reminded geneticists working on inflammatory bowel diseases (IBDs) of the more modest contribution of genetics to the predisposition to ulcerative colitis, reflected in a lower ratio of disease concordance between monozygotic and dizygotic twins.4 The lower heritability of ulcerative colitis also accounts for the fact that most of the linkage studies performed in the 1990s did not include sufficient ulcerative colitis-affected sib pairs to disclose ulcerative colitis-related loci. With few exceptions,5 6 7 reports of associations with candidate genes have not been confirmed. Recently, major advances in cataloguing common genetic variants in humans combined with the development of high-throughput single nucleotide polymorphism (SNP) genotyping capacity, have made large-scale, genome-wide association studies (GWASs) with hundreds of thousands of common SNPs feasible. These have dramatically increased the list of loci shown to be associated with Crohn’s disease,8 9 10 11 12 13 and now also with ulcerative colitis14 15 16 17 (table 1).View this table:Table 1 Single nucleotide polymorphisms (SNPs) significantly associated with ulcerative colitis, identified through genome-wide association studies15 16 17 or systematic testing after significant association with Crohn’s disease in genome-wide association studies14 …" @default.
• W2022898802 created "2016-06-24" @default.
• W2022898802 creator A5006016461 @default.
• W2022898802 creator A5026868068 @default.
• W2022898802 creator A5038112249 @default.
• W2022898802 creator A5075153118 @default.
• W2022898802 creator A5078128200 @default.
• W2022898802 date "2009-08-11" @default.
• W2022898802 modified "2023-09-28" @default.
• W2022898802 title "Genetics of ulcerative colitis: the come-back of interleukin 10" @default.
• W2022898802 cites W1551725906 @default.
• W2022898802 cites W1642457845 @default.
• W2022898802 cites W1670573097 @default.
• W2022898802 cites W1968067289 @default.
• W2022898802 cites W1981714996 @default.
• W2022898802 cites W1983571964 @default.
• W2022898802 cites W2010203932 @default.
• W2022898802 cites W2011197968 @default.
• W2022898802 cites W2017599614 @default.
• W2022898802 cites W2028402416 @default.
• W2022898802 cites W2030784582 @default.
• W2022898802 cites W2036500213 @default.
• W2022898802 cites W2042432586 @default.
• W2022898802 cites W2052017014 @default.
• W2022898802 cites W2060160394 @default.
• W2022898802 cites W2074742896 @default.
• W2022898802 cites W2085110576 @default.
• W2022898802 cites W2088449391 @default.
• W2022898802 cites W2094464340 @default.
• W2022898802 cites W2100443415 @default.
• W2022898802 cites W2103357560 @default.
• W2022898802 cites W2103494646 @default.
• W2022898802 cites W2108030329 @default.
• W2022898802 cites W2111437358 @default.
• W2022898802 cites W2111791268 @default.
• W2022898802 cites W2114466604 @default.
• W2022898802 cites W2116178189 @default.
• W2022898802 cites W2116552560 @default.
• W2022898802 cites W2118688515 @default.
• W2022898802 cites W2122031852 @default.
• W2022898802 cites W2134783591 @default.
• W2022898802 cites W2141125135 @default.
• W2022898802 cites W2153318159 @default.
• W2022898802 cites W2159068998 @default.
• W2022898802 cites W2160855953 @default.
• W2022898802 cites W2164861161 @default.
• W2022898802 cites W2165528446 @default.
• W2022898802 cites W2168647393 @default.
• W2022898802 doi "https://doi.org/10.1136/gut.2008.169235" @default.
• W2022898802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19671546" @default.
• W2022898802 hasPublicationYear "2009" @default.
• W2022898802 type Work @default.
• W2022898802 sameAs 2022898802 @default.
• W2022898802 citedByCount "22" @default.
• W2022898802 countsByYear W20228988022012 @default.
• W2022898802 countsByYear W20228988022013 @default.
• W2022898802 countsByYear W20228988022014 @default.
• W2022898802 countsByYear W20228988022016 @default.
• W2022898802 countsByYear W20228988022017 @default.
• W2022898802 countsByYear W20228988022018 @default.
• W2022898802 countsByYear W20228988022020 @default.
• W2022898802 crossrefType "journal-article" @default.
• W2022898802 hasAuthorship W2022898802A5006016461 @default.
• W2022898802 hasAuthorship W2022898802A5026868068 @default.
• W2022898802 hasAuthorship W2022898802A5038112249 @default.
• W2022898802 hasAuthorship W2022898802A5075153118 @default.
• W2022898802 hasAuthorship W2022898802A5078128200 @default.
• W2022898802 hasBestOaLocation W20228988022 @default.
• W2022898802 hasConcept C126322002 @default.
• W2022898802 hasConcept C203014093 @default.
• W2022898802 hasConcept C2775862500 @default.
• W2022898802 hasConcept C2777572184 @default.
• W2022898802 hasConcept C2779134260 @default.
• W2022898802 hasConcept C2780479503 @default.
• W2022898802 hasConcept C71924100 @default.
• W2022898802 hasConcept C90924648 @default.
• W2022898802 hasConceptScore W2022898802C126322002 @default.
• W2022898802 hasConceptScore W2022898802C203014093 @default.
• W2022898802 hasConceptScore W2022898802C2775862500 @default.
• W2022898802 hasConceptScore W2022898802C2777572184 @default.
• W2022898802 hasConceptScore W2022898802C2779134260 @default.
• W2022898802 hasConceptScore W2022898802C2780479503 @default.
• W2022898802 hasConceptScore W2022898802C71924100 @default.
• W2022898802 hasConceptScore W2022898802C90924648 @default.
• W2022898802 hasIssue "9" @default.
• W2022898802 hasLocation W20228988021 @default.
• W2022898802 hasLocation W20228988022 @default.
• W2022898802 hasLocation W20228988023 @default.
• W2022898802 hasOpenAccess W2022898802 @default.
• W2022898802 hasPrimaryLocation W20228988021 @default.
• W2022898802 hasRelatedWork W1979201123 @default.
• W2022898802 hasRelatedWork W1981227935 @default.
• W2022898802 hasRelatedWork W2059801240 @default.
• W2022898802 hasRelatedWork W2085839725 @default.
• W2022898802 hasRelatedWork W2097304057 @default.
• W2022898802 hasRelatedWork W2116840281 @default.
• W2022898802 hasRelatedWork W2327338788 @default.
• W2022898802 hasRelatedWork W2391106790 @default.

• next