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- W2022898832 abstract "Natural products have served as an important source of medicinal compounds and pharmaceutical leads over the last century. Within the last 10 years, significant interest has developed in applying combinatorial chemistry techniques to the study of natural products and their biological activities. In this review, we examine several representative efforts wherein natural product skeletons have been constructed or immobilized on solid support and subsequently derivatized, giving rise to analog libraries useful in understanding the structure–activity relationships of the parent natural product. Issues such as target selection, library design, linker development, automation, and library characterization are addressed. © 2001 John Wiley & Sons, Inc. Biopolymers (Pept Sci) 60: 171–193, 2001" @default.
- W2022898832 created "2016-06-24" @default.
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- W2022898832 date "2001-01-01" @default.
- W2022898832 modified "2023-10-17" @default.
- W2022898832 title "Solid phase synthesis of complex natural products and libraries thereof" @default.
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- W2022898832 doi "https://doi.org/10.1002/1097-0282(2001)60:3<171::aid-bip10030>3.0.co;2-m" @default.
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