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- W2022900528 abstract "Tissue distribution of UDP-glucuronyltransferase was investigated using two substrate groups which were shown to be conjugated by two different forms of this enzyme in previous studies with rat liver. These enzyme forms were found to be differentially inducible by 3-methylcholanthrene (form 1) and phenobarbital (form 2). Group 1 substrates (conjugated by form 1) include 1-naphthol, N-hydroxy-2-naphthylamine and 3-hydroxybenzo[a]pyrene; group 2 substrates (conjugated by form 2) comprise 4-hydroxybiphenyl, morphine and chloramphenicol. Group 1 substrates are conjugated in a number of tissues, for example, liver, kidney, small intestinal mucosa, lung, skin, testes and spleen. However, conjugation of group 2 substrates is detectable only in liver and intestine to an appreciable extent. It is concluded that enzyme(s) efficient in the conjugation of group 1 substrates is ubiquitous in the investigated organs, whilst only liver and intestine possess enzyme(s) efficient in the conjugation of group 2 substrates. In contrast to 3-hydroxybenzo[a]pyrene, benzo[a]pyrene 7,8-dihydrodiol cannot be clearly associated with only one of the 2 substrate groups. Glucuronidation of benzo[a]pyrene 7.8-dihydrodiol is enhanced by both phenobarbital and 3-methylcholanthrene in liver. Conjugation of the dihydrodiol is detectable in all tissues examined. However, enzyme activity towards the dihydrodiol is much lower than that towards 3-hydroxybenzo[a]pyrene. It is disproportionately low with skin microsomes." @default.
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- W2022900528 date "1980-02-01" @default.
- W2022900528 modified "2023-10-01" @default.
- W2022900528 title "Functional heterogeneity of UDP-glucuronyltransferase in rat tissues" @default.
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- W2022900528 doi "https://doi.org/10.1016/0006-2952(80)90368-8" @default.
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