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- W2022904912 abstract "Embryonic stem (ES) cells are under precise control of both intrinsic self-renewal gene regulatory network and extrinsic growth factor-triggered signaling cascades. How external signaling pathways connect to core self-renewal transcriptional circuits is largely unknown. To probe this, we chose BMP signaling, which is previously recognized as a master control for both self-renewal and lineage commitment of murine ES cells. Here, we mapped target gene promoter occupancy of SMAD1/5 and SMAD4 on a genome-wide scale and found that they associate with a large group of developmental regulators that are enriched for H3K27 trimethylation and H3K4 trimethylation bivalent marks and are repressed in the self-renewing state, whereas they are rapidly induced upon differentiation. Smad knockdown experiments further indicate that SMAD-mediated BMP signaling is largely required for differentiation-related processes rather than directly influencing self-renewal. Among the SMAD-associated genes, we further identified Dpysl2 (previously known as Crmp2) and the H3K27 demethylase Kdm6b (previously known as Jmjd3) as BMP4-modulated early neural differentiation regulators. Combined with computational analysis, our results suggest that SMAD-mediated BMP signaling balances self-renewal versus differentiation by modulating a set of developmental regulators." @default.
- W2022904912 created "2016-06-24" @default.
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- W2022904912 date "2009-11-19" @default.
- W2022904912 modified "2023-10-16" @default.
- W2022904912 title "Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination" @default.
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- W2022904912 cites W1988294855 @default.
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- W2022904912 cites W2017840637 @default.
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- W2022904912 doi "https://doi.org/10.1101/gr.092114.109" @default.
- W2022904912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2798829" @default.
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