FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022910414> ?p ?o ?g. }

• W2022910414 endingPage "AB105" @default.
• W2022910414 startingPage "AB105" @default.
• W2022910414 abstract "RationaleAllergic reactions to systemic corticoids are uncommon, especially immediate-type reactions. Here we present a patient with an anaphylactic reaction due to 6-methyl-prednisolone.MethodsAfter written informed consent, we perfomed the following drug allergy studyResultsA 38 year-old man received a single intravenous dose of 6-methyl-prednisolone (40 mg) to treat an asthma attack. Immediately after the dose he suffered abdominal pain, nausea, vomiting and generalized pruritus, angioedema in his lips, hands and face. After this, dizziness, tachycardia, and intense sweating appeared. He was treated with intramuscular epinephrine, intravenous saline fluid and an intravenous dose of difenhidramine (polaramine ®). He was under hospital observation until he completely recovered.We performed a prick test with soluble 6 methyl-prednisolone (hemisuccinate ester) with a positive result (7 mm diameter). The prick and intradermal tests with oral methyl-prednisolone (succinate ester), hidrocortisone, prednisone and fluticasone were negative.We perfomed an oral challenge test with oral prednisone up to 80 mg, intravenous hydrocortisone up to 200 mg and 1 puff of inhaled fluticasone (250 mcg), all of them with good tolerance.ConclusionsWe have diagnosed an anaphylactic reaction caused by 6-methyl-prednisolone confirmed by a positive prick test. We have confirmed that the patient tolerated methyl-prednisolone, and so we think that he was sensitized only to hemisuccinate but not to succinate esters as in other published cases. Due to the widespread use of these drugs, it’s important to give safe corticoids alternatives to these patients performing drug challenges after negative prick or intradermal tests. RationaleAllergic reactions to systemic corticoids are uncommon, especially immediate-type reactions. Here we present a patient with an anaphylactic reaction due to 6-methyl-prednisolone. Allergic reactions to systemic corticoids are uncommon, especially immediate-type reactions. Here we present a patient with an anaphylactic reaction due to 6-methyl-prednisolone. MethodsAfter written informed consent, we perfomed the following drug allergy study After written informed consent, we perfomed the following drug allergy study ResultsA 38 year-old man received a single intravenous dose of 6-methyl-prednisolone (40 mg) to treat an asthma attack. Immediately after the dose he suffered abdominal pain, nausea, vomiting and generalized pruritus, angioedema in his lips, hands and face. After this, dizziness, tachycardia, and intense sweating appeared. He was treated with intramuscular epinephrine, intravenous saline fluid and an intravenous dose of difenhidramine (polaramine ®). He was under hospital observation until he completely recovered.We performed a prick test with soluble 6 methyl-prednisolone (hemisuccinate ester) with a positive result (7 mm diameter). The prick and intradermal tests with oral methyl-prednisolone (succinate ester), hidrocortisone, prednisone and fluticasone were negative.We perfomed an oral challenge test with oral prednisone up to 80 mg, intravenous hydrocortisone up to 200 mg and 1 puff of inhaled fluticasone (250 mcg), all of them with good tolerance. A 38 year-old man received a single intravenous dose of 6-methyl-prednisolone (40 mg) to treat an asthma attack. Immediately after the dose he suffered abdominal pain, nausea, vomiting and generalized pruritus, angioedema in his lips, hands and face. After this, dizziness, tachycardia, and intense sweating appeared. He was treated with intramuscular epinephrine, intravenous saline fluid and an intravenous dose of difenhidramine (polaramine ®). He was under hospital observation until he completely recovered. We performed a prick test with soluble 6 methyl-prednisolone (hemisuccinate ester) with a positive result (7 mm diameter). The prick and intradermal tests with oral methyl-prednisolone (succinate ester), hidrocortisone, prednisone and fluticasone were negative. We perfomed an oral challenge test with oral prednisone up to 80 mg, intravenous hydrocortisone up to 200 mg and 1 puff of inhaled fluticasone (250 mcg), all of them with good tolerance. ConclusionsWe have diagnosed an anaphylactic reaction caused by 6-methyl-prednisolone confirmed by a positive prick test. We have confirmed that the patient tolerated methyl-prednisolone, and so we think that he was sensitized only to hemisuccinate but not to succinate esters as in other published cases. Due to the widespread use of these drugs, it’s important to give safe corticoids alternatives to these patients performing drug challenges after negative prick or intradermal tests. We have diagnosed an anaphylactic reaction caused by 6-methyl-prednisolone confirmed by a positive prick test. We have confirmed that the patient tolerated methyl-prednisolone, and so we think that he was sensitized only to hemisuccinate but not to succinate esters as in other published cases. Due to the widespread use of these drugs, it’s important to give safe corticoids alternatives to these patients performing drug challenges after negative prick or intradermal tests." @default.
• W2022910414 created "2016-06-24" @default.
• W2022910414 creator A5016952800 @default.
• W2022910414 creator A5018318280 @default.
• W2022910414 creator A5018367645 @default.
• W2022910414 creator A5037416483 @default.
• W2022910414 creator A5073656425 @default.
• W2022910414 creator A5078326067 @default.
• W2022910414 creator A5084861201 @default.
• W2022910414 date "2012-02-01" @default.
• W2022910414 modified "2023-10-09" @default.
• W2022910414 title "Anaphylactic Reaction After 6-methyl-prednisolone" @default.
• W2022910414 doi "https://doi.org/10.1016/j.jaci.2011.12.522" @default.
• W2022910414 hasPublicationYear "2012" @default.
• W2022910414 type Work @default.
• W2022910414 sameAs 2022910414 @default.
• W2022910414 citedByCount "0" @default.
• W2022910414 crossrefType "journal-article" @default.
• W2022910414 hasAuthorship W2022910414A5016952800 @default.
• W2022910414 hasAuthorship W2022910414A5018318280 @default.
• W2022910414 hasAuthorship W2022910414A5018367645 @default.
• W2022910414 hasAuthorship W2022910414A5037416483 @default.
• W2022910414 hasAuthorship W2022910414A5073656425 @default.
• W2022910414 hasAuthorship W2022910414A5078326067 @default.
• W2022910414 hasAuthorship W2022910414A5084861201 @default.
• W2022910414 hasConcept C126322002 @default.
• W2022910414 hasConcept C141071460 @default.
• W2022910414 hasConcept C16005928 @default.
• W2022910414 hasConcept C203014093 @default.
• W2022910414 hasConcept C207480886 @default.
• W2022910414 hasConcept C2775933838 @default.
• W2022910414 hasConcept C2776042228 @default.
• W2022910414 hasConcept C2776715498 @default.
• W2022910414 hasConcept C2777995640 @default.
• W2022910414 hasConcept C2778720950 @default.
• W2022910414 hasConcept C2780852908 @default.
• W2022910414 hasConcept C42219234 @default.
• W2022910414 hasConcept C71924100 @default.
• W2022910414 hasConcept C90924648 @default.
• W2022910414 hasConceptScore W2022910414C126322002 @default.
• W2022910414 hasConceptScore W2022910414C141071460 @default.
• W2022910414 hasConceptScore W2022910414C16005928 @default.
• W2022910414 hasConceptScore W2022910414C203014093 @default.
• W2022910414 hasConceptScore W2022910414C207480886 @default.
• W2022910414 hasConceptScore W2022910414C2775933838 @default.
• W2022910414 hasConceptScore W2022910414C2776042228 @default.
• W2022910414 hasConceptScore W2022910414C2776715498 @default.
• W2022910414 hasConceptScore W2022910414C2777995640 @default.
• W2022910414 hasConceptScore W2022910414C2778720950 @default.
• W2022910414 hasConceptScore W2022910414C2780852908 @default.
• W2022910414 hasConceptScore W2022910414C42219234 @default.
• W2022910414 hasConceptScore W2022910414C71924100 @default.
• W2022910414 hasConceptScore W2022910414C90924648 @default.
• W2022910414 hasIssue "2" @default.
• W2022910414 hasLocation W20229104141 @default.
• W2022910414 hasOpenAccess W2022910414 @default.
• W2022910414 hasPrimaryLocation W20229104141 @default.
• W2022910414 hasRelatedWork W1994646951 @default.
• W2022910414 hasRelatedWork W2005255640 @default.
• W2022910414 hasRelatedWork W2020556773 @default.
• W2022910414 hasRelatedWork W2101880291 @default.
• W2022910414 hasRelatedWork W2106261603 @default.
• W2022910414 hasRelatedWork W2407620367 @default.
• W2022910414 hasRelatedWork W2427327111 @default.
• W2022910414 hasRelatedWork W2581453553 @default.
• W2022910414 hasRelatedWork W2771824900 @default.
• W2022910414 hasRelatedWork W4243646261 @default.
• W2022910414 hasVolume "129" @default.
• W2022910414 isParatext "false" @default.
• W2022910414 isRetracted "false" @default.
• W2022910414 magId "2022910414" @default.
• W2022910414 workType "article" @default.