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- W2022915034 abstract "The function of the urea biosynthetic pathway in mammalian liver is to convert excess ammonia to urea and to maintain the ammonia concentration at non-toxic levels. Activities of the hepatic enzymes adapt to increasing or decreasing dietary protein. The pathway contributes minor amounts of intermediates such as citrulline or arginine to the circulation. Adult intestine has the first two enzymes of the pathway and is capable of synthesizing citrulline. Unlike these two enzymes in liver, their activity is not affected by changes in dietary protein. It has been shown in the rat, that intestinally-produced citrulline is carried by the blood stream to the kidney where it is converted by the next two enzymes of the pathway to arginine (Windmueller). This mechanism serves as the source of circulating arginine in the adult. We have found that, at birth, the arginine synthesizing enzymes in mouse kidney are minimally developed, while in the intestine, the citrulline synthesizing enzymes are elevated. However, argininosuccinate synthetase and lyase, usually present only in trace quantities in the adult, are markedly developed in the newborn. Arginase which converts arginine to urea, does not appear in intestinal cells until the age of 15 days. This finding would suggest that newborn mouse intestine, with a complete and functioning arginine synthesizing pathway, is the primary endogenous source of arginine in the neonatal mouse." @default.
- W2022915034 created "2016-06-24" @default.
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- W2022915034 date "1985-04-01" @default.
- W2022915034 modified "2023-09-27" @default.
- W2022915034 title "274 DEVELOPMENT OF ARGININE SYNTHESIZING ENZYMES IN MOUSE INTESTINE" @default.
- W2022915034 doi "https://doi.org/10.1203/00006450-198504000-00304" @default.
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