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• W2022921023 abstract "BACKGROUND We examined the separate and joint effects of gestational age, size at birth and maternal race/ethnicity on early childhood survival among 48,391 singleton infants with major birth defects. METHODS Texas Birth Defects Registry data were linked to death records and the National Death Index to ascertain deaths. Gestational age categories were preterm or term birth; size at birth included small for gestational age (SGA), appropriate for gestational age (AGA), and large for gestational age (LGA). Kaplan-Meier survival estimates were calculated, and Cox-proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) to determine risk of death after adjusting for covariates. RESULTS Overall, relative to non-Hispanic (NH) -whites, NH-blacks, and Hispanics had a 51 and 10% greater risk of death during early childhood, respectively. Compared to NH-whites born term and AGA (survival = 97%), Hispanic children born SGA and preterm had the greatest risk of death (HRa = 6.1; 95% CI, 5.2, 7.2) and the lowest early childhood survival (76%), followed by SGA preterm NH-blacks (HRa = 4.8; 95% CI, 3.6, 6.5; survival = 81%) and SGA preterm NH-whites (HRa = 4.5; 95% CI, 3.7, 5.6; survival = 83%). Children born LGA at term had no increased risk of mortality regardless of maternal race/ethnicity. CONCLUSIONS The joint effect of gestational age and size at birth had greatest impact on childhood mortality. Additional population based studies are needed to better understand causes of racial/ethnic disparities in mortality among children with birth defects. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc." @default.
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• W2022921023 date "2010-07-29" @default.
• W2022921023 modified "2023-10-08" @default.
• W2022921023 title "Mortality among infants with birth defects: Joint effects of size at birth, gestational age, and maternal race/ethnicity" @default.
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• W2022921023 doi "https://doi.org/10.1002/bdra.20696" @default.
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