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- W2022921743 abstract "Recent preclinical advances highlight the therapeutic potential of treatments aimed at boosting regeneration and plasticity of spinal circuitry damaged by spinal cord injury (SCI). With several promising candidates being considered for translation into clinical trials, the SCI community has called for a non-human primate model as a crucial validation step to test efficacy and validity of these therapies prior to human testing. The present paper reviews the previous and ongoing efforts of the California Spinal Cord Consortium (CSCC), a multidisciplinary team of experts from 5 University of California medical and research centers, to develop this crucial translational SCI model. We focus on the growing volumes of high resolution data collected by the CSCC, and our efforts to develop a biomedical informatics framework aimed at leveraging multidimensional data to monitor plasticity and repair targeting recovery of hand and arm function. Although the main focus of many researchers is the restoration of voluntary motor control, we also describe our ongoing efforts to add assessments of sensory function, including pain, vital signs during surgery, and recovery of bladder and bowel function. By pooling our multidimensional data resources and building a unified database infrastructure for this clinically relevant translational model of SCI, we are now in a unique position to test promising therapeutic strategies' efficacy on the entire syndrome of SCI. We review analyses highlighting the intersection between motor, sensory, autonomic and pathological contributions to the overall restoration of function. This article is part of a Special Issue entitled SI: Spinal cord injury." @default.
- W2022921743 created "2016-06-24" @default.
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- W2022921743 date "2015-09-01" @default.
- W2022921743 modified "2023-10-17" @default.
- W2022921743 title "Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury" @default.
- W2022921743 cites W123790764 @default.
- W2022921743 cites W1490428798 @default.
- W2022921743 cites W1522766796 @default.
- W2022921743 cites W1546932693 @default.
- W2022921743 cites W1595932248 @default.
- W2022921743 cites W1607601486 @default.
- W2022921743 cites W1940297232 @default.
- W2022921743 cites W1965180763 @default.
- W2022921743 cites W1966602829 @default.
- W2022921743 cites W1967148795 @default.
- W2022921743 cites W1967949062 @default.
- W2022921743 cites W1968282384 @default.
- W2022921743 cites W1970295814 @default.
- W2022921743 cites W1971916180 @default.
- W2022921743 cites W1972303806 @default.
- W2022921743 cites W1974432822 @default.
- W2022921743 cites W1978351609 @default.
- W2022921743 cites W1979942439 @default.
- W2022921743 cites W1980859391 @default.
- W2022921743 cites W1981020626 @default.
- W2022921743 cites W1983304221 @default.
- W2022921743 cites W1983325630 @default.
- W2022921743 cites W1987408946 @default.
- W2022921743 cites W1989493703 @default.
- W2022921743 cites W1994229359 @default.
- W2022921743 cites W1995190455 @default.
- W2022921743 cites W1998075613 @default.
- W2022921743 cites W2001168381 @default.
- W2022921743 cites W2004323875 @default.
- W2022921743 cites W2009924073 @default.
- W2022921743 cites W2010862256 @default.
- W2022921743 cites W2012798142 @default.
- W2022921743 cites W2012924135 @default.
- W2022921743 cites W2013033561 @default.
- W2022921743 cites W2017374559 @default.
- W2022921743 cites W2020122922 @default.
- W2022921743 cites W2032606215 @default.
- W2022921743 cites W2034099577 @default.
- W2022921743 cites W2035529930 @default.
- W2022921743 cites W2037702549 @default.
- W2022921743 cites W2039139807 @default.
- W2022921743 cites W2039716494 @default.
- W2022921743 cites W2040420020 @default.
- W2022921743 cites W2042778187 @default.
- W2022921743 cites W2044777958 @default.
- W2022921743 cites W2048060485 @default.
- W2022921743 cites W2051785463 @default.
- W2022921743 cites W2054548538 @default.
- W2022921743 cites W2055353767 @default.
- W2022921743 cites W2056679870 @default.
- W2022921743 cites W2056715261 @default.
- W2022921743 cites W2062844197 @default.
- W2022921743 cites W2066270711 @default.
- W2022921743 cites W2066945027 @default.
- W2022921743 cites W2067208808 @default.
- W2022921743 cites W2073751266 @default.
- W2022921743 cites W2078792829 @default.
- W2022921743 cites W2081930221 @default.
- W2022921743 cites W2085512194 @default.
- W2022921743 cites W2087907462 @default.
- W2022921743 cites W2090518955 @default.
- W2022921743 cites W2091940856 @default.
- W2022921743 cites W2093274439 @default.
- W2022921743 cites W2094154961 @default.
- W2022921743 cites W2094215712 @default.
- W2022921743 cites W2094502082 @default.
- W2022921743 cites W2096761689 @default.
- W2022921743 cites W2099854052 @default.
- W2022921743 cites W2104105197 @default.
- W2022921743 cites W2106457523 @default.
- W2022921743 cites W2107904697 @default.