FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022921764> ?p ?o ?g. }

• W2022921764 endingPage "63" @default.
• W2022921764 startingPage "57" @default.
• W2022921764 abstract "Melanin concentrating hormone (MCH) is a 19 amino-acid peptide expressed in high concentrations within the dorso-lateral hypothalamus of rats, sheep and man. MCH regulates skin colour and ACTH release in teleost fish, however, its physiological relevance in mammals is unclear. The present study examined the cardiovascular and metabolic actions of intracerebroventricular (i.c.v.) infusion of MCH, and the pro-MCH derived peptide Neuropeptide-E-I (NEI), in conscious, chronically instrumented sheep. Human MCH (1-19) or NEI (1-13) was infused i.c.v. for 24 h into 6 sheep, and measurements were made every 10 min of arterial pressure, heart rate, cardiac output, stroke volume and peripheral blood flow/conductance. Recordings of water intake (H2Oin), urine volume (Uv), urinary Na (UNaV) and K excretion (UKV) were made, as well as hematocrit, plasma Na, K, osmolality, protein, glucose, ACTH, vasopressin, renin, endothelin, ANF, cortisol and aldosterone concentrations. After 24 h of infusion at 10 microg/h, MCH produced a significant increase in Uv from 0.8 +/- 0.2 to 1.4 +/- 0.3 l/day, together with an increase in UNaV from 56 +/- 8 to 107 +/- 14 mmol/day, and in UKV from 202 +/- 18 to 369 +/- 38 mmol/day. H2Oin was unchanged. Similar renal changes were observed during i.c.v. infusion of NEI. There was no change in any cardiovascular parameter, although hematocrit showed a large decrease with infusion of both peptides after 24 h infusion. Plasma osmolality increased from 291 +/- 1 to 295 +/- 1 mOsm/kg during MCH infusion, whereas total protein and plasma Na and K were unchanged. MCH increased plasma glucose from 3.4 +/- 0.2 to 3.8 +/- 0.2 mmol/l. Plasma aldosterone exhibited a 30-40% decrease following MCH or NEI infusion, whereas all other plasma concentrations remained unchanged. This study has shown that i.c.v. infusion of MCH or NEI can produce diuretic, natriuretic and kaliuretic changes in conscious sheep, triggered by a possible increase in plasma volume as indicated by the changes in hematocrit. These results, together with anatomical data reporting the presence of MCH/NEI in fluid regulatory areas of the brain, indicate that MCH/NEI may be an important peptide involved in the central control of fluid homeostasis in mammals." @default.
• W2022921764 created "2016-06-24" @default.
• W2022921764 creator A5077809872 @default.
• W2022921764 date "1996-01-01" @default.
• W2022921764 modified "2023-09-23" @default.
• W2022921764 title "Diuretic and Natriuretic Actions of Melanin Concentrating Hormone in Conscious Sheep" @default.
• W2022921764 cites W1965556955 @default.
• W2022921764 cites W1978082185 @default.
• W2022921764 cites W1979127822 @default.
• W2022921764 cites W1981503938 @default.
• W2022921764 cites W1982034861 @default.
• W2022921764 cites W1995442217 @default.
• W2022921764 cites W1996328680 @default.
• W2022921764 cites W1999214497 @default.
• W2022921764 cites W2000825182 @default.
• W2022921764 cites W2001512814 @default.
• W2022921764 cites W2002876776 @default.
• W2022921764 cites W2009712927 @default.
• W2022921764 cites W2024428069 @default.
• W2022921764 cites W2031587745 @default.
• W2022921764 cites W2046265271 @default.
• W2022921764 cites W2059660390 @default.
• W2022921764 cites W2068732630 @default.
• W2022921764 cites W2073148375 @default.
• W2022921764 cites W2085197251 @default.
• W2022921764 cites W2086924813 @default.
• W2022921764 cites W2087530434 @default.
• W2022921764 cites W2092115378 @default.
• W2022921764 cites W2094259909 @default.
• W2022921764 cites W4237212669 @default.
• W2022921764 cites W4249932114 @default.
• W2022921764 cites W4256605812 @default.
• W2022921764 cites W8054040 @default.
• W2022921764 cites W963227066 @default.
• W2022921764 doi "https://doi.org/10.1111/j.1365-2826.1996.tb00686.x" @default.
• W2022921764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8932737" @default.
• W2022921764 hasPublicationYear "1996" @default.
• W2022921764 type Work @default.
• W2022921764 sameAs 2022921764 @default.
• W2022921764 citedByCount "29" @default.
• W2022921764 countsByYear W20229217642015 @default.
• W2022921764 countsByYear W20229217642021 @default.
• W2022921764 crossrefType "journal-article" @default.
• W2022921764 hasAuthorship W2022921764A5077809872 @default.
• W2022921764 hasConcept C118303440 @default.
• W2022921764 hasConcept C126322002 @default.
• W2022921764 hasConcept C134018914 @default.
• W2022921764 hasConcept C170493617 @default.
• W2022921764 hasConcept C185592680 @default.
• W2022921764 hasConcept C2776370428 @default.
• W2022921764 hasConcept C2776632733 @default.
• W2022921764 hasConcept C2778525890 @default.
• W2022921764 hasConcept C2778534349 @default.
• W2022921764 hasConcept C2779420931 @default.
• W2022921764 hasConcept C2780959883 @default.
• W2022921764 hasConcept C2908929049 @default.
• W2022921764 hasConcept C71315377 @default.
• W2022921764 hasConcept C71924100 @default.
• W2022921764 hasConcept C84393581 @default.
• W2022921764 hasConceptScore W2022921764C118303440 @default.
• W2022921764 hasConceptScore W2022921764C126322002 @default.
• W2022921764 hasConceptScore W2022921764C134018914 @default.
• W2022921764 hasConceptScore W2022921764C170493617 @default.
• W2022921764 hasConceptScore W2022921764C185592680 @default.
• W2022921764 hasConceptScore W2022921764C2776370428 @default.
• W2022921764 hasConceptScore W2022921764C2776632733 @default.
• W2022921764 hasConceptScore W2022921764C2778525890 @default.
• W2022921764 hasConceptScore W2022921764C2778534349 @default.
• W2022921764 hasConceptScore W2022921764C2779420931 @default.
• W2022921764 hasConceptScore W2022921764C2780959883 @default.
• W2022921764 hasConceptScore W2022921764C2908929049 @default.
• W2022921764 hasConceptScore W2022921764C71315377 @default.
• W2022921764 hasConceptScore W2022921764C71924100 @default.
• W2022921764 hasConceptScore W2022921764C84393581 @default.
• W2022921764 hasIssue "1" @default.
• W2022921764 hasLocation W20229217641 @default.
• W2022921764 hasLocation W20229217642 @default.
• W2022921764 hasOpenAccess W2022921764 @default.
• W2022921764 hasPrimaryLocation W20229217641 @default.
• W2022921764 hasRelatedWork W1964596246 @default.
• W2022921764 hasRelatedWork W1991185913 @default.
• W2022921764 hasRelatedWork W1992220075 @default.
• W2022921764 hasRelatedWork W2003587549 @default.
• W2022921764 hasRelatedWork W2024736606 @default.
• W2022921764 hasRelatedWork W2040558763 @default.
• W2022921764 hasRelatedWork W2071155830 @default.
• W2022921764 hasRelatedWork W2125221738 @default.
• W2022921764 hasRelatedWork W2146713571 @default.
• W2022921764 hasRelatedWork W2151139437 @default.
• W2022921764 hasVolume "8" @default.
• W2022921764 isParatext "false" @default.
• W2022921764 isRetracted "false" @default.
• W2022921764 magId "2022921764" @default.
• W2022921764 workType "article" @default.