Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022921874> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2022921874 endingPage "270" @default.
- W2022921874 startingPage "267" @default.
- W2022921874 abstract "In this study, we used an experimental model of cardiac hypertrophy to explore the role of the kallikrein-kinin system (KKS) in cardiac protection in transgenic rats harboring the human tissue kallikrein gene, TGR(hKLK1). Tissue kallikrein cleaves low-molecular-weight kininogen to produce kinin peptides, which bind to kinin receptors and trigger a wide spectrum of biological effects. The transgene, under the control of the zinc-inducible metallothionein promoter, was expressed in most tissues including the heart, kidney, lung and brain. These animals were subjected to treatment with thyroid hormone in order to promote cardiac hypertrophy. Induction of cardiac hypertrophy revealed a marked protective effect caused by the expression of the kallikrein transgene, evidenced by the significantly reduced cardiac weight gain and the lower enhancement in the cardiac expression of atrial natriuretic peptide and collagen III, markers for hypertrophy and fibrosis, respectively. In conclusion, our data show that expression of tissue kallikrein exerts antihypertrophic and antifibrotic actions in the heart." @default.
- W2022921874 created "2016-06-24" @default.
- W2022921874 creator A5007982412 @default.
- W2022921874 creator A5026755014 @default.
- W2022921874 creator A5038260780 @default.
- W2022921874 creator A5039371456 @default.
- W2022921874 creator A5083413598 @default.
- W2022921874 date "2008-02-01" @default.
- W2022921874 modified "2023-09-30" @default.
- W2022921874 title "Protective actions of human tissue kallikrein gene in transgenic rat hearts" @default.
- W2022921874 cites W1569637715 @default.
- W2022921874 cites W1982728555 @default.
- W2022921874 cites W1997812290 @default.
- W2022921874 cites W2028701593 @default.
- W2022921874 cites W2028761750 @default.
- W2022921874 cites W2055698093 @default.
- W2022921874 cites W2071793778 @default.
- W2022921874 cites W2077722354 @default.
- W2022921874 cites W2079585262 @default.
- W2022921874 cites W2123696429 @default.
- W2022921874 cites W2136148759 @default.
- W2022921874 cites W2149404585 @default.
- W2022921874 cites W2152613954 @default.
- W2022921874 cites W2162782596 @default.
- W2022921874 cites W2398870876 @default.
- W2022921874 cites W2411552542 @default.
- W2022921874 doi "https://doi.org/10.1016/j.intimp.2007.09.005" @default.
- W2022921874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18182238" @default.
- W2022921874 hasPublicationYear "2008" @default.
- W2022921874 type Work @default.
- W2022921874 sameAs 2022921874 @default.
- W2022921874 citedByCount "1" @default.
- W2022921874 countsByYear W20229218742019 @default.
- W2022921874 crossrefType "journal-article" @default.
- W2022921874 hasAuthorship W2022921874A5007982412 @default.
- W2022921874 hasAuthorship W2022921874A5026755014 @default.
- W2022921874 hasAuthorship W2022921874A5038260780 @default.
- W2022921874 hasAuthorship W2022921874A5039371456 @default.
- W2022921874 hasAuthorship W2022921874A5083413598 @default.
- W2022921874 hasConcept C102230213 @default.
- W2022921874 hasConcept C104317684 @default.
- W2022921874 hasConcept C126322002 @default.
- W2022921874 hasConcept C134018914 @default.
- W2022921874 hasConcept C141035611 @default.
- W2022921874 hasConcept C150194340 @default.
- W2022921874 hasConcept C167414201 @default.
- W2022921874 hasConcept C170493617 @default.
- W2022921874 hasConcept C181199279 @default.
- W2022921874 hasConcept C198710026 @default.
- W2022921874 hasConcept C2776246183 @default.
- W2022921874 hasConcept C2777902427 @default.
- W2022921874 hasConcept C2779591629 @default.
- W2022921874 hasConcept C2780559512 @default.
- W2022921874 hasConcept C52853521 @default.
- W2022921874 hasConcept C55493867 @default.
- W2022921874 hasConcept C71924100 @default.
- W2022921874 hasConcept C84393581 @default.
- W2022921874 hasConcept C86803240 @default.
- W2022921874 hasConceptScore W2022921874C102230213 @default.
- W2022921874 hasConceptScore W2022921874C104317684 @default.
- W2022921874 hasConceptScore W2022921874C126322002 @default.
- W2022921874 hasConceptScore W2022921874C134018914 @default.
- W2022921874 hasConceptScore W2022921874C141035611 @default.
- W2022921874 hasConceptScore W2022921874C150194340 @default.
- W2022921874 hasConceptScore W2022921874C167414201 @default.
- W2022921874 hasConceptScore W2022921874C170493617 @default.
- W2022921874 hasConceptScore W2022921874C181199279 @default.
- W2022921874 hasConceptScore W2022921874C198710026 @default.
- W2022921874 hasConceptScore W2022921874C2776246183 @default.
- W2022921874 hasConceptScore W2022921874C2777902427 @default.
- W2022921874 hasConceptScore W2022921874C2779591629 @default.
- W2022921874 hasConceptScore W2022921874C2780559512 @default.
- W2022921874 hasConceptScore W2022921874C52853521 @default.
- W2022921874 hasConceptScore W2022921874C55493867 @default.
- W2022921874 hasConceptScore W2022921874C71924100 @default.
- W2022921874 hasConceptScore W2022921874C84393581 @default.
- W2022921874 hasConceptScore W2022921874C86803240 @default.
- W2022921874 hasIssue "2" @default.
- W2022921874 hasLocation W20229218741 @default.
- W2022921874 hasLocation W20229218742 @default.
- W2022921874 hasOpenAccess W2022921874 @default.
- W2022921874 hasPrimaryLocation W20229218741 @default.
- W2022921874 hasRelatedWork W1024032912 @default.
- W2022921874 hasRelatedWork W1973919641 @default.
- W2022921874 hasRelatedWork W1980431627 @default.
- W2022921874 hasRelatedWork W1993779036 @default.
- W2022921874 hasRelatedWork W2028701593 @default.
- W2022921874 hasRelatedWork W2143589272 @default.
- W2022921874 hasRelatedWork W2144816184 @default.
- W2022921874 hasRelatedWork W2407672575 @default.
- W2022921874 hasRelatedWork W2414960153 @default.
- W2022921874 hasRelatedWork W4246983568 @default.
- W2022921874 hasVolume "8" @default.
- W2022921874 isParatext "false" @default.
- W2022921874 isRetracted "false" @default.
- W2022921874 magId "2022921874" @default.
- W2022921874 workType "article" @default.