FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022923311> ?p ?o ?g. }

• W2022923311 endingPage "2361" @default.
• W2022923311 startingPage "2356" @default.
• W2022923311 abstract "Abstract: The effect of clinical, spontaneous-onset seizures on extracellular fluid lactate was investigated by the method of lactography, the in vivo on-line measurement of lactate levels using microdialysis. Studies of experimental animals have suggested that generation of extracellular lactate as measured by microdialysis is an index of local glucose utilization and is dependent on the activity of neurons under physiological conditions. Patients with medically refractory complex partial epilepsy underwent stereo-tactic implantation of combination depth electrode/micro-dialysis probes into both hippocampi for 7–16 days. During spontaneous complex partial seizures with secondary generalization, extracellular lactate levels rose by 91 β 32%. Moreover, this increase persisted for 60–90 min. During a unilateral hippocampal seizure that did not propagate to the contralateral hippocampus, the increase in lactate content was restricted to the side of seizure activity. Between seizures, extracellular lactate levels correlated with the frequency of interictal spikes. In summary, these data suggest that brief clinical seizures increase nonoxidative glucose metabolism significantly as measured by the generation of extracellular lactate. Furthermore, the increase in extracellular lactate level is limited to the site of seizure activity. Lactate is transported extracellularly via a lactate/proton cotransporter; therefore, the rise in extracellular lactate level may mediate the drop in pHo associated with seizure activity. As acidification of the extracellular compartment has an inhibitory effect on neuronal excitability, the rise in extracellular lactate content may be a mechanism of seizure arrest and postictal refractoriness. Moreover, extracellular lactate may also mediate the decreased seizure susceptibility associated with frequent interictal spikes." @default.
• W2022923311 created "2016-06-24" @default.
• W2022923311 creator A5003922053 @default.
• W2022923311 creator A5057770234 @default.
• W2022923311 creator A5065786104 @default.
• W2022923311 creator A5070693463 @default.
• W2022923311 creator A5087533290 @default.
• W2022923311 date "2008-06-28" @default.
• W2022923311 modified "2023-10-07" @default.
• W2022923311 title "Direct Measurement of Extracellular Lactate in the Human Hippocampus During Spontaneous Seizures" @default.
• W2022923311 cites W17133634 @default.
• W2022923311 cites W1968470516 @default.
• W2022923311 cites W1972030495 @default.
• W2022923311 cites W1974231491 @default.
• W2022923311 cites W1977938101 @default.
• W2022923311 cites W1982774084 @default.
• W2022923311 cites W1985992749 @default.
• W2022923311 cites W1987562415 @default.
• W2022923311 cites W1991316313 @default.
• W2022923311 cites W1993303421 @default.
• W2022923311 cites W1997070105 @default.
• W2022923311 cites W2015067348 @default.
• W2022923311 cites W2018627425 @default.
• W2022923311 cites W2026489163 @default.
• W2022923311 cites W2028522929 @default.
• W2022923311 cites W203221303 @default.
• W2022923311 cites W2033456548 @default.
• W2022923311 cites W2034298442 @default.
• W2022923311 cites W2047106164 @default.
• W2022923311 cites W2048011585 @default.
• W2022923311 cites W2056640605 @default.
• W2022923311 cites W2064139713 @default.
• W2022923311 cites W2067055660 @default.
• W2022923311 cites W2068108309 @default.
• W2022923311 cites W2072302223 @default.
• W2022923311 cites W2079900056 @default.
• W2022923311 cites W2102106700 @default.
• W2022923311 cites W2112457470 @default.
• W2022923311 cites W2114461073 @default.
• W2022923311 cites W2116394679 @default.
• W2022923311 cites W2133570175 @default.
• W2022923311 cites W2133963133 @default.
• W2022923311 cites W2157590017 @default.
• W2022923311 cites W2158516688 @default.
• W2022923311 cites W2167104996 @default.
• W2022923311 cites W2257725504 @default.
• W2022923311 cites W2412674874 @default.
• W2022923311 cites W2414288299 @default.
• W2022923311 cites W2599287240 @default.
• W2022923311 doi "https://doi.org/10.1046/j.1471-4159.1994.62062356.x" @default.
• W2022923311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8189240" @default.
• W2022923311 hasPublicationYear "2008" @default.
• W2022923311 type Work @default.
• W2022923311 sameAs 2022923311 @default.
• W2022923311 citedByCount "100" @default.
• W2022923311 countsByYear W20229233112012 @default.
• W2022923311 countsByYear W20229233112013 @default.
• W2022923311 countsByYear W20229233112014 @default.
• W2022923311 countsByYear W20229233112015 @default.
• W2022923311 countsByYear W20229233112016 @default.
• W2022923311 countsByYear W20229233112017 @default.
• W2022923311 countsByYear W20229233112018 @default.
• W2022923311 countsByYear W20229233112019 @default.
• W2022923311 countsByYear W20229233112020 @default.
• W2022923311 countsByYear W20229233112021 @default.
• W2022923311 countsByYear W20229233112022 @default.
• W2022923311 countsByYear W20229233112023 @default.
• W2022923311 crossrefType "journal-article" @default.
• W2022923311 hasAuthorship W2022923311A5003922053 @default.
• W2022923311 hasAuthorship W2022923311A5057770234 @default.
• W2022923311 hasAuthorship W2022923311A5065786104 @default.
• W2022923311 hasAuthorship W2022923311A5070693463 @default.
• W2022923311 hasAuthorship W2022923311A5087533290 @default.
• W2022923311 hasConcept C126322002 @default.
• W2022923311 hasConcept C134018914 @default.
• W2022923311 hasConcept C148762608 @default.
• W2022923311 hasConcept C169760540 @default.
• W2022923311 hasConcept C17755696 @default.
• W2022923311 hasConcept C185592680 @default.
• W2022923311 hasConcept C2113261 @default.
• W2022923311 hasConcept C2777010014 @default.
• W2022923311 hasConcept C2778186239 @default.
• W2022923311 hasConcept C2781161787 @default.
• W2022923311 hasConcept C28406088 @default.
• W2022923311 hasConcept C50156730 @default.
• W2022923311 hasConcept C55493867 @default.
• W2022923311 hasConcept C71924100 @default.
• W2022923311 hasConcept C86803240 @default.
• W2022923311 hasConceptScore W2022923311C126322002 @default.
• W2022923311 hasConceptScore W2022923311C134018914 @default.
• W2022923311 hasConceptScore W2022923311C148762608 @default.
• W2022923311 hasConceptScore W2022923311C169760540 @default.
• W2022923311 hasConceptScore W2022923311C17755696 @default.
• W2022923311 hasConceptScore W2022923311C185592680 @default.
• W2022923311 hasConceptScore W2022923311C2113261 @default.
• W2022923311 hasConceptScore W2022923311C2777010014 @default.
• W2022923311 hasConceptScore W2022923311C2778186239 @default.
• W2022923311 hasConceptScore W2022923311C2781161787 @default.

• next