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- W2022930450 abstract "Andrographolide is a major bioctive compound found in king of bitter ( Andrographis paniculata ). In this study, the extraction method and its condition were investigated in order to get an extract with maximum amount of andrographolide by comparing three other extraction methods, i.e. maceration, soxhletation and ultrasonication and also determination for the optimum condition of the selected extraction method. The highest andrographolide amount was found by maceration, so this method was choosen for further optimization of extraction condition. The optimum condition based on the prediction amount from 27 factor combinations was obtained in 360 times of extraction time, 2g/100mL of sample to solvent ratio, and 3fold of extraction frequency with prediction of andrographolide amount was 3.50%. While by using prediction profile, the optimum condition was obtained in 360min of extraction time, 2 g/100mL of sample and solvent ratio, and 4 times of extraction frequency with the amount was 3.47-3.74%." @default.
- W2022930450 created "2016-06-24" @default.
- W2022930450 creator A5083855342 @default.
- W2022930450 date "2014-07-01" @default.
- W2022930450 modified "2023-09-22" @default.
- W2022930450 title "OPTIMIZATION OF EXTRACTION CONDITIONS FOR ANDROGRAPHOLIDE USING FRACTIONAL FACTORIAL DESIGN" @default.
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- W2022930450 doi "https://doi.org/10.14499/indonesianjpharm25iss3pp145" @default.
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