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- W2022932940 abstract "Abstract Human hepatoma (SMMC-7721) and normal liver (L02) cells were irradiated with γ-rays, 12 C 6+ and 36 Ar 18+ ion beams at the Heavy Ion Research Facility in Lanzhou (HIRFL). By using the Calyculin-A induced premature chromosome condensation technique, chromatid-type breaks and isochromatid-type breaks were scored separately. Tumor cells irradiated with heavy ions produced a majority of isochromatid break, while chromatid breaks were dominant when cells were exposed to γ-rays. The relative biological effectiveness (RBE) for irradiation-induced chromatid breaks were 3.6 for L02 and 3.5 for SMMC-7721 cell lines at the LET peak of 96 keVμm −1 12 C 6+ ions, and 2.9 for both of the two cell lines of 512 keVμm −1 36 Ar 18+ ions. It suggested that the RBE of isochromatid-type breaks was pretty high when high-LET radiations were induced. Thus we concluded that the high production of isochromatid-type breaks, induced by the densely ionizing track structure, could be regarded as a signature of high-LET radiation exposure." @default.
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- W2022932940 date "2009-05-01" @default.
- W2022932940 modified "2023-09-29" @default.
- W2022932940 title "Radiosensitivity of hepatoma cell lines and human normal liver cell lines exposed in vitro to carbon ions and argon ions at the HIRFL" @default.
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- W2022932940 doi "https://doi.org/10.1016/j.nimb.2009.03.004" @default.
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