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• W2022937591 abstract "The chronic administration of 10 mg/kg/day of dipyridamole to rats produced 33.7% inhibition of platelet aggregation induced with ADP and a 93% increase in 6-keto-prostaglandin F1α (6-keto-PGF1α) in vascular samples, versus saline-treated rats. Mopidamol, 8.3 mg/kg/day, caused 50.6% inhibition of ADP-induced platelet aggregation, 37.6% inhibition of aggregation induced with arachidonic acid, a 47.6% decrease in serum levels of thromboxane B2 and a 23.7% increase in the vascular production of 6-keto-PGF1α, versus saline-treated rats. Dipyridamole showed a higher in vitro anti-aggregating effect in whole blood (IC50 6.6 μM) than in platelet-rich plasma (PRP) (IC50, 210μM), when ADP was used as inducer, and had no effect in the presence of arachidonic acid. Mopidamol exerted a similar effect in whole blood (IC50 3.7–20 μM, depending on the inducer) and PRP (IC50 11-17.3 μM), and showed a dose-dependent inhibition of platelet aggregation and thromboxane B2 synthesis induced with arachidonic acid (IC50 16.8–22.3 μM). Mopidamol also inhibited enzymatically induced lipid peroxidation) (IC50 89 ± 5.9 μmol/L) and had no effect on free radical-induced lipid peroxidation. The dose-dependent increase in 6-keto-PGF1α in vascular samples after incubation with dipyridamole showed a negative linear correlation with inhibition of lipid peroxidation (τ2 = 0.77). It is concluded that the phosphodiesterase inhibitors, dipyridamole and mopidamol, interfere in a different manner with platelet function. It seems that mopidamol may also exert a selective effect on platelet thromboxane synthesis." @default.
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• W2022937591 date "1994-01-01" @default.
• W2022937591 modified "2023-09-30" @default.
• W2022937591 title "Differential effects of the pyrimido-pyrimidine derivatives, dipyridamole and mopidamol, on platelet and vascular cyclooxygenase activity" @default.
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• W2022937591 doi "https://doi.org/10.1016/0006-2952(94)90008-6" @default.
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