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- W2022941470 abstract "Eicosanoids have been historically involved in the pathogenesis of various inflammatory diseases. Lipoxins (LXs) and epi-LXs show physiological effects relevant to inflammation regulation. In this study, we focused on LX precursors based on the hypothesis that their entrance and metabolism into the cell may facilitate their targeting at the inflammation site. Because compound chirality is of considerable importance in the efficacy of therapeutic agents, our aim was to study the anti-inflammatory effects of various epimers of LXA4 precursors compared to LXA4. Blood polymorphonuclear cells (PMNs) were incubated with 15(S)- or 15(R)-hydroxyeicosatetraenoic acid (HETE), 14(R)-,15(S)-, or 14(S),15(S)-diHETE, and LXA4 and then stimulated with the calcium ionophore A23187. We found that 15(R)-HETE rather than 15(S)-HETE was preferentially metabolized and that 15-epi-LXs were produced in larger amounts than LXs. In contrast, when PMNs were incubated with the diastereoisomers of 14,15(S)-diHETE, 14-epi-LXB4 was produced in lower amounts than LXB4. Enantiomers of 15-HETE and diastereoisomers of 14,15-diHETE and LXA4 were able to significantly decrease LTB4 release by PMNs. These results suggest a potential resolution of the inflammatory process through endogenous anti-inflammatory mediators released by the way of trans-cellular metabolism." @default.
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- W2022941470 date "2002-01-01" @default.
- W2022941470 modified "2023-09-27" @default.
- W2022941470 title "Endogenous Anti-inflammatory Mediators from Arachidonate in Human Neutrophils" @default.
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- W2022941470 doi "https://doi.org/10.1006/bbrc.2001.6155" @default.
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