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- W2022941636 abstract "Abstract Chlorpromazine (CPZ, 0.15mM) inhibited the uptake and incorporation of hypoxanthine into TCA-soluble and TCA-insoluble fractions in the MH 1 C 1 rat hepatoma cell line to 38 and 49 per cent of control values, respectively. Diethylaminoethyl diphenylvalerate (SKF 525-A, 0.20 mM) also reduced hypoxanthine uptake and incorporation in the TCA-soluble and TCA-insoluble fractions to 38 and 41 percent, respectively. When nucleic acid synthesis was blocked with actinomycin D and cytosine arabinoside, hypoxanthine uptake was also diminished; CPZ (0.15 mM) further reduced hypoxanthine uptake in the TCA-soluble fraction. The cells showed a time dependent uptake and incorporation of thymidine and uridine; CPZ also inhibited the uptake and incorporation of these nucleosides, but to a much smaller extent than hypoxanthine. CPZ (0.15mM) reduced the thymidine uptake into the TCA-soluble fraction to 71 per cent of controls and those of uridine to 83 per cent of controls. The inhibitory effects of CPZ and SKF 525-A on hypoxanthine and nucleoside uptake and incorporation were equally evident in a fibroblast-derived cell line. It is concluded that CPZ and SKF 525-A inhibit the transport of hypoxanthine and to a lesser degree the transport of thymidine and uridine in the cell cultures." @default.
- W2022941636 created "2016-06-24" @default.
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- W2022941636 date "1973-08-01" @default.
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- W2022941636 title "Inhibition of hypoxanthine transport by chlorpromazine and skf 525-A in cell culture" @default.
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- W2022941636 doi "https://doi.org/10.1016/0006-2952(73)90080-4" @default.
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