FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022942017> ?p ?o ?g. }

• W2022942017 endingPage "90" @default.
• W2022942017 startingPage "84" @default.
• W2022942017 abstract "The native promoter of β1,3 galactosyltransferase β3Gal-T5 contributes to the expression of the enzyme and its oligosaccharide products, such as Lewis antigens, in many tissues. It is mainly sensitive to nuclear factor NF-Y and located nearby two CpG islands. To elucidate the regulation of the native promoter, we analyzed NF-Y protein and β3Gal-T5 mRNA, and found that NF-Y is scarcely modulated among various cell lines and biopsies from normal or cancerous colon. Conversely, β3Gal-T5 expression levels vary in the cell lines and are strongly down-regulated in colon cancer. We also performed quantitative methylation analysis of β3Gal-T5 CpG islands and found an inverse correlation between mRNA expression and DNA methylation. In particular, the methylation levels of both islands are always increased in cancer, with respect to the corresponding normal counterpart, in matched normal and tumor samples of colon and breast origin. Moreover, treatment with chromatin remodeling agents 5-aza-2'deoxycytidine and trichostatin A does not restore transcription in completely negative cells, but only increases expression in basally positive cells. However, methylation analysis after 5-aza-2'deoxycytidine treatment revealed partial demethylation of both islands in all treated cells. Finally, chromatin immunoprecipitation assays on β3Gal-T5 promoter showed that histone H3K4 trymethylation, H3K79 dimethylation, and H3K9-14 acetylation are high in cells expressing the transcript, and very low in those negative, while H4K20 trimethylation and H3K27 dimethylation are the opposite. We conclude that complex epigenetic modulation underlies the regulation of β3Gal-T5 native promoter." @default.
• W2022942017 created "2016-06-24" @default.
• W2022942017 creator A5005347599 @default.
• W2022942017 creator A5009615069 @default.
• W2022942017 creator A5031774888 @default.
• W2022942017 creator A5034936946 @default.
• W2022942017 creator A5048252980 @default.
• W2022942017 creator A5077344895 @default.
• W2022942017 date "2012-01-01" @default.
• W2022942017 modified "2023-09-23" @default.
• W2022942017 title "DNA methylation and histone modifications modulate the β1,3 galactosyltransferase β3Gal-T5 native promoter in cancer cells" @default.
• W2022942017 cites W1508125605 @default.
• W2022942017 cites W1535685697 @default.
• W2022942017 cites W1572307742 @default.
• W2022942017 cites W1968186443 @default.
• W2022942017 cites W1971625212 @default.
• W2022942017 cites W1976626368 @default.
• W2022942017 cites W1998564246 @default.
• W2022942017 cites W1999347965 @default.
• W2022942017 cites W2005272275 @default.
• W2022942017 cites W2012508528 @default.
• W2022942017 cites W2015259303 @default.
• W2022942017 cites W2017813525 @default.
• W2022942017 cites W2028868300 @default.
• W2022942017 cites W2030324144 @default.
• W2022942017 cites W2031346959 @default.
• W2022942017 cites W2033062154 @default.
• W2022942017 cites W2038969950 @default.
• W2022942017 cites W2053088231 @default.
• W2022942017 cites W2056898550 @default.
• W2022942017 cites W2056932875 @default.
• W2022942017 cites W2081052881 @default.
• W2022942017 cites W2084852182 @default.
• W2022942017 cites W2087141183 @default.
• W2022942017 cites W2093009120 @default.
• W2022942017 cites W2117091421 @default.
• W2022942017 cites W2120988920 @default.
• W2022942017 cites W2123629596 @default.
• W2022942017 cites W2123812852 @default.
• W2022942017 cites W2124317124 @default.
• W2022942017 cites W2134241603 @default.
• W2022942017 cites W2139398990 @default.
• W2022942017 cites W2144826548 @default.
• W2022942017 cites W2151527385 @default.
• W2022942017 cites W2154087715 @default.
• W2022942017 cites W2171256063 @default.
• W2022942017 doi "https://doi.org/10.1016/j.biocel.2011.09.010" @default.
• W2022942017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22001559" @default.
• W2022942017 hasPublicationYear "2012" @default.
• W2022942017 type Work @default.
• W2022942017 sameAs 2022942017 @default.
• W2022942017 citedByCount "23" @default.
• W2022942017 countsByYear W20229420172012 @default.
• W2022942017 countsByYear W20229420172013 @default.
• W2022942017 countsByYear W20229420172014 @default.
• W2022942017 countsByYear W20229420172015 @default.
• W2022942017 countsByYear W20229420172016 @default.
• W2022942017 countsByYear W20229420172017 @default.
• W2022942017 countsByYear W20229420172019 @default.
• W2022942017 countsByYear W20229420172020 @default.
• W2022942017 countsByYear W20229420172021 @default.
• W2022942017 crossrefType "journal-article" @default.
• W2022942017 hasAuthorship W2022942017A5005347599 @default.
• W2022942017 hasAuthorship W2022942017A5009615069 @default.
• W2022942017 hasAuthorship W2022942017A5031774888 @default.
• W2022942017 hasAuthorship W2022942017A5034936946 @default.
• W2022942017 hasAuthorship W2022942017A5048252980 @default.
• W2022942017 hasAuthorship W2022942017A5077344895 @default.
• W2022942017 hasConcept C101762097 @default.
• W2022942017 hasConcept C104317684 @default.
• W2022942017 hasConcept C114691636 @default.
• W2022942017 hasConcept C134320426 @default.
• W2022942017 hasConcept C140173407 @default.
• W2022942017 hasConcept C150194340 @default.
• W2022942017 hasConcept C153911025 @default.
• W2022942017 hasConcept C185592680 @default.
• W2022942017 hasConcept C190727270 @default.
• W2022942017 hasConcept C2777865847 @default.
• W2022942017 hasConcept C2778305200 @default.
• W2022942017 hasConcept C2779277951 @default.
• W2022942017 hasConcept C33288867 @default.
• W2022942017 hasConcept C37080517 @default.
• W2022942017 hasConcept C41091548 @default.
• W2022942017 hasConcept C502942594 @default.
• W2022942017 hasConcept C552990157 @default.
• W2022942017 hasConcept C55493867 @default.
• W2022942017 hasConcept C64927066 @default.
• W2022942017 hasConcept C83640560 @default.
• W2022942017 hasConcept C86803240 @default.
• W2022942017 hasConceptScore W2022942017C101762097 @default.
• W2022942017 hasConceptScore W2022942017C104317684 @default.
• W2022942017 hasConceptScore W2022942017C114691636 @default.
• W2022942017 hasConceptScore W2022942017C134320426 @default.
• W2022942017 hasConceptScore W2022942017C140173407 @default.
• W2022942017 hasConceptScore W2022942017C150194340 @default.
• W2022942017 hasConceptScore W2022942017C153911025 @default.
• W2022942017 hasConceptScore W2022942017C185592680 @default.
• W2022942017 hasConceptScore W2022942017C190727270 @default.

• next