FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022942610> ?p ?o ?g. }

• W2022942610 endingPage "27294" @default.
• W2022942610 startingPage "27288" @default.
• W2022942610 abstract "The NADPH oxidase cytochromeb 558 is a membrane heterodimer comprised of a glycosylated 91-kDa subunit, gp91 phox, and a nonglycosylated 22-kDa subunit, p22 phox. The role of heme in cytochrome b 558 biosynthesis was studied using succinyl acetone, an inhibitor of heme synthesis, in PLB-985 myeloid cells undergoing granulocytic differentiation. Succinyl acetone markedly reduced expression of p22 phox and the mature 91-kDa form of gp91 phox but not its 65-kDa high mannose precursor, in association with a profound reduction in NADPH oxidase activity. Expression of non-heme-containing cytosolic oxidase components was unaffected. The reduction in cytochrome b 558 expression and NADPH oxidase activity was prevented by adding exogenous heme and was reversible upon removal of succinyl acetone. Transgenic expression of gp91 phox in monkey COS-7 and murine 3T3 cells, both of which lacked endogenous p22 phox mRNA, demonstrated that p22 phox was not required for maturation of gp91 phox carbohydrate to complex oligosaccharides. However, coexpression of transgenic p22 phox increased the abundance of the mature gp91 phox glycoprotein. These results suggest that heme incorporation plays an important role in cytochromeb 558 assembly and provide further support for the concept that stability of p22 phox and the mature gp91 phox subunit is increased by heterodimer formation." @default.
• W2022942610 created "2016-06-24" @default.
• W2022942610 creator A5022663465 @default.
• W2022942610 creator A5060621536 @default.
• W2022942610 creator A5071248323 @default.
• W2022942610 date "1997-10-01" @default.
• W2022942610 modified "2023-10-14" @default.
• W2022942610 title "Biosynthesis of the Phagocyte NADPH Oxidase Cytochromeb 558" @default.
• W2022942610 cites W1435781716 @default.
• W2022942610 cites W1489866685 @default.
• W2022942610 cites W1508700142 @default.
• W2022942610 cites W1519473807 @default.
• W2022942610 cites W1535247289 @default.
• W2022942610 cites W1539883814 @default.
• W2022942610 cites W1543728556 @default.
• W2022942610 cites W1566004432 @default.
• W2022942610 cites W1572714473 @default.
• W2022942610 cites W1583193370 @default.
• W2022942610 cites W1583760582 @default.
• W2022942610 cites W1591151754 @default.
• W2022942610 cites W1810573536 @default.
• W2022942610 cites W19008044 @default.
• W2022942610 cites W1940122864 @default.
• W2022942610 cites W1971193426 @default.
• W2022942610 cites W1973466729 @default.
• W2022942610 cites W1985766505 @default.
• W2022942610 cites W1997502223 @default.
• W2022942610 cites W1999883129 @default.
• W2022942610 cites W2004145071 @default.
• W2022942610 cites W2011002812 @default.
• W2022942610 cites W2014520088 @default.
• W2022942610 cites W2018542299 @default.
• W2022942610 cites W2019640011 @default.
• W2022942610 cites W2020671950 @default.
• W2022942610 cites W2025054558 @default.
• W2022942610 cites W2029665225 @default.
• W2022942610 cites W2043794330 @default.
• W2022942610 cites W2054821808 @default.
• W2022942610 cites W2060193350 @default.
• W2022942610 cites W2062155334 @default.
• W2022942610 cites W2071799329 @default.
• W2022942610 cites W2076055514 @default.
• W2022942610 cites W2079436411 @default.
• W2022942610 cites W2085794106 @default.
• W2022942610 cites W2090228650 @default.
• W2022942610 cites W2090977537 @default.
• W2022942610 cites W2092042958 @default.
• W2022942610 cites W2119518322 @default.
• W2022942610 cites W2143908574 @default.
• W2022942610 cites W2189017812 @default.
• W2022942610 cites W2340855393 @default.
• W2022942610 cites W2414983659 @default.
• W2022942610 cites W303205414 @default.
• W2022942610 cites W4232997016 @default.
• W2022942610 cites W4294216491 @default.
• W2022942610 cites W936023199 @default.
• W2022942610 doi "https://doi.org/10.1074/jbc.272.43.27288" @default.
• W2022942610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9341176" @default.
• W2022942610 hasPublicationYear "1997" @default.
• W2022942610 type Work @default.
• W2022942610 sameAs 2022942610 @default.
• W2022942610 citedByCount "151" @default.
• W2022942610 countsByYear W20229426102012 @default.
• W2022942610 countsByYear W20229426102013 @default.
• W2022942610 countsByYear W20229426102014 @default.
• W2022942610 countsByYear W20229426102015 @default.
• W2022942610 countsByYear W20229426102016 @default.
• W2022942610 countsByYear W20229426102017 @default.
• W2022942610 countsByYear W20229426102018 @default.
• W2022942610 countsByYear W20229426102019 @default.
• W2022942610 countsByYear W20229426102020 @default.
• W2022942610 countsByYear W20229426102021 @default.
• W2022942610 countsByYear W20229426102022 @default.
• W2022942610 countsByYear W20229426102023 @default.
• W2022942610 crossrefType "journal-article" @default.
• W2022942610 hasAuthorship W2022942610A5022663465 @default.
• W2022942610 hasAuthorship W2022942610A5060621536 @default.
• W2022942610 hasAuthorship W2022942610A5071248323 @default.
• W2022942610 hasBestOaLocation W20229426101 @default.
• W2022942610 hasConcept C160448771 @default.
• W2022942610 hasConcept C181199279 @default.
• W2022942610 hasConcept C185592680 @default.
• W2022942610 hasConcept C2777700362 @default.
• W2022942610 hasConcept C2779719074 @default.
• W2022942610 hasConcept C38485361 @default.
• W2022942610 hasConcept C553450214 @default.
• W2022942610 hasConcept C55493867 @default.
• W2022942610 hasConcept C86803240 @default.
• W2022942610 hasConcept C89423630 @default.
• W2022942610 hasConceptScore W2022942610C160448771 @default.
• W2022942610 hasConceptScore W2022942610C181199279 @default.
• W2022942610 hasConceptScore W2022942610C185592680 @default.
• W2022942610 hasConceptScore W2022942610C2777700362 @default.
• W2022942610 hasConceptScore W2022942610C2779719074 @default.
• W2022942610 hasConceptScore W2022942610C38485361 @default.
• W2022942610 hasConceptScore W2022942610C553450214 @default.
• W2022942610 hasConceptScore W2022942610C55493867 @default.
• W2022942610 hasConceptScore W2022942610C86803240 @default.

• next