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- W2022943412 abstract "Kinetic isotope effects (KIEs) on the yeast α-glucosidase-catalyzed hydrolysis of two α-d-glucopyranosyl pyridinium salts were measured at 25 °C and pH = 6.8. The measured KIEs on kcat for the 2H-2, 13C-1, and 15N-1‘ labeled substrates α-d-glucopyranosyl pyridinium bromide (1) and α-d-glucopyranosyl isoquinolinium bromide (2) were, respectively, 1.115 ± 0.006 and 1.106 ± 0.009, 1.028 ± 0.006 and 1.027 ± 0.005, and 1.019 ± 0.007 and 0.985 ± 0.005. KIEs for the spontaneous hydrolysis of α-d-glucopyranosyl 4‘-bromoisoquinolinium bromide (3) were measured at 80 °C and pH = 6.8. The measured KIEs on khyd for the 2H-1, 2H-2, 13C-1, and 15N-1‘ labeled substrate α-d-glucopyranosyl 4‘-bromoisoquinolinium bromide (3) were, respectively, 1.189 ± 0.009, 1.094 ± 0.010, 1.005 ± 0.002, and 1.015 ± 0.004. The KIEs obtained in this study of yeast α-glucosidase-catalyzed hydrolysis reactions are consistent with a transition state which involves a small degree of nucleophilic attack by an enzyme active site carboxylate grou..." @default.
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- W2022943412 title "Glucosidase-Catalyzed Hydrolysis of α-<scp>d</scp>-Glucopyranosyl Pyridinium Salts: Kinetic Evidence for Nucleophilic Involvement at the Glucosidation Transition State" @default.
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