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- W2022943625 abstract "Vascular targeting photodynamic therapy (vPDT) is currently in clinical trial for prostate cancer (PCa)treatment. In order to study the effect of vPDT on tumor metastasis, GFP-PC3 or PC-3 xenografts weretreated with verteporfin (BPD) PDT. Vascular function was assessed by ultrasound imaging; lymph node andlung metastasis were assessed by fluorescence imaging. vPDT significantly reduced tumor blood flow within30minutes to 2 hours of treatment. Sub-curative treatment resulted in re-perfusion within 2 weeks of treatmentand increased lymph node metastasis. With curative doses, no metastasis was observed.In order to identify cellular or matrix factors and cytokines implicated, conditioned medium from BPD PDTtreatedendothelial cells was incubated with PC3 cells in vitro. Tumor cell proliferation and migration wasassessed. By immunoblotting, we evaluated the change in mediators of intracellular signaling or that maydetermine changes in tumor phenotype. Low sub-curative dose (200ng/ml BPD) of endothelial cells wasassociated with ~15% greater migration in PC3 cells when compared with control. This dose was alsoassociated with sustained activation of Akt at Ser 473, an upstream effector in the Akt/ mTOR pathway thathas been correlated with Gleason scores in PCa and with survival and metastasis in vitro and in vivo. Inconclusion, the study implicates efficacy of PDT of endothelial cells as an important determinant of itsconsequences on adjacent tumor proliferation and metastasis." @default.
- W2022943625 created "2016-06-24" @default.
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- W2022943625 date "2009-06-29" @default.
- W2022943625 modified "2023-09-23" @default.
- W2022943625 title "Effects of vascular targeting photodynamic therapy on lymphatic tumor metastasis" @default.
- W2022943625 doi "https://doi.org/10.1117/12.823061" @default.
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