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- W2022943820 abstract "Summary Background: The superior postoperative pain relief of epidural sufentanil in combination with local anesthetics following major surgery is not seriously questioned any longer. However, safety concerns have restricted the use of epidural opioids on general wards in many European countries. Therefore, this investigation focuses on the quality of pain relief as well as the incidence of side effects under continuous epidural analgesia with and without sufentanil 1 μg/ml under the conditions of a community hospital. Methods: In a double-blind randomized controlled trial 100 patients scheduled for major abdominal surgery were assigned to receive either epidural bupivacaine 0.125% (6–12 ml/h) (group B) or bupivacaine 0.125% and sufentanil 1 μg/ml (6–12 ml/h) (group BS) for postoperative analgesia. The amount of rescue medication (piritramide i.v., PCA), pain intensity, adverse events and vital signs were registered during the first 24 h. Results: The pain intensity at rest and while coughing was significantly lower in group BS. Group BS required significantly less rescue medication. Sedation occurred significantly more often in group B, likely due to the increased use of rescue medication. The incidence of hypotension was 66% without group differences. Conclusion: The addition of sufentanil to bupivacaine 0.125% improves postoperative epidural analgesia without increasing the incidence of severe side effects." @default.
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- W2022943820 date "2004-12-01" @default.
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- W2022943820 title "Epidural sufentanil for postoperative analgesia following major abdominal surgery" @default.
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- W2022943820 doi "https://doi.org/10.1016/j.acpain.2004.08.001" @default.
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