FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022950239> ?p ?o ?g. }

• W2022950239 endingPage "107" @default.
• W2022950239 startingPage "97" @default.
• W2022950239 abstract "We previously reported that bacterial products such as LPS and CpG DNA down-modulated cell surface levels of the Colony Stimulating Factor (CSF)-1 receptor (CSF-1R) on primary murine macrophages in an all-or-nothing manner. Here we show that the ability of bacterial products to down-modulate the CSF-1R rendered bone marrow-derived macrophages (BMM) unresponsive to CSF-1 as assessed by Akt and ERK1/2 phosphorylation. Using toll-like receptor (tlr)9 as a model CSF-1-repressed gene, we show that LPS induced tlr9 expression in BMM only when CSF-1 was present, suggesting that LPS relieves CSF-1-mediated inhibition to induce gene expression. Using cDNA microarrays, we identified a cluster of similarly CSF-1 repressed genes in BMM. By real time PCR we confirmed that the expression of a selection of these genes, including integral membrane protein 2B (itm2b), receptor activity-modifying protein 2 (ramp2) and macrophage-specific gene 1 (mpg-1), were repressed by CSF-1 and were induced by LPS only in the presence of CSF-1. This pattern of gene regulation was also apparent in thioglycollate-elicited peritoneal macrophages (TEPM). LPS also counteracted CSF-1 action to induce mRNA expression of a number of transcription factors including interferon consensus sequence binding protein 1 (Icsbp1), suggesting that this mechanism leads to transcriptional reprogramming in macrophages. Since the majority of in vitro studies on macrophage biology do not include CSF-1, these genes represent a set of previously uncharacterised LPS-inducible genes. This study identifies a new mechanism of macrophage activation, in which LPS (and other toll-like receptor agonists) regulate gene expression by switching off the CSF-1R signal. This finding also provides a biological relevance to the well-documented ability of macrophage activators to down-modulate surface expression of the CSF-1R." @default.
• W2022950239 created "2016-06-24" @default.
• W2022950239 creator A5005883374 @default.
• W2022950239 creator A5009690319 @default.
• W2022950239 creator A5018063097 @default.
• W2022950239 creator A5020634099 @default.
• W2022950239 creator A5023240519 @default.
• W2022950239 creator A5026924357 @default.
• W2022950239 creator A5029662334 @default.
• W2022950239 creator A5032097008 @default.
• W2022950239 creator A5041587646 @default.
• W2022950239 creator A5046551226 @default.
• W2022950239 creator A5054128852 @default.
• W2022950239 creator A5057848962 @default.
• W2022950239 creator A5072188738 @default.
• W2022950239 creator A5086500057 @default.
• W2022950239 date "2005-08-01" @default.
• W2022950239 modified "2023-09-26" @default.
• W2022950239 title "LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action" @default.
• W2022950239 cites W1638480194 @default.
• W2022950239 cites W1869320174 @default.
• W2022950239 cites W1875567118 @default.
• W2022950239 cites W1880318558 @default.
• W2022950239 cites W1900738890 @default.
• W2022950239 cites W1930598094 @default.
• W2022950239 cites W1964730873 @default.
• W2022950239 cites W1964846497 @default.
• W2022950239 cites W1974013472 @default.
• W2022950239 cites W1978837231 @default.
• W2022950239 cites W1979956993 @default.
• W2022950239 cites W2009239615 @default.
• W2022950239 cites W2019835722 @default.
• W2022950239 cites W2025687125 @default.
• W2022950239 cites W2026644950 @default.
• W2022950239 cites W2028563003 @default.
• W2022950239 cites W2031603575 @default.
• W2022950239 cites W2038564346 @default.
• W2022950239 cites W2046649601 @default.
• W2022950239 cites W2049043736 @default.
• W2022950239 cites W2062035070 @default.
• W2022950239 cites W2065020204 @default.
• W2022950239 cites W2075010026 @default.
• W2022950239 cites W2087096844 @default.
• W2022950239 cites W2091493364 @default.
• W2022950239 cites W2098687187 @default.
• W2022950239 cites W2098898636 @default.
• W2022950239 cites W2100696348 @default.
• W2022950239 cites W2101363646 @default.
• W2022950239 cites W2104904748 @default.
• W2022950239 cites W2108399976 @default.
• W2022950239 cites W2111112233 @default.
• W2022950239 cites W2114175515 @default.
• W2022950239 cites W2119114699 @default.
• W2022950239 cites W2124941872 @default.
• W2022950239 cites W2127580144 @default.
• W2022950239 cites W2129643405 @default.
• W2022950239 cites W2130559596 @default.
• W2022950239 cites W2140942452 @default.
• W2022950239 cites W2151777859 @default.
• W2022950239 cites W2152098493 @default.
• W2022950239 cites W2157530588 @default.
• W2022950239 cites W2157671063 @default.
• W2022950239 cites W2159923852 @default.
• W2022950239 cites W2165182490 @default.
• W2022950239 cites W2285587112 @default.
• W2022950239 cites W2326903946 @default.
• W2022950239 cites W4322388185 @default.
• W2022950239 doi "https://doi.org/10.1016/j.imbio.2005.05.004" @default.
• W2022950239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16164016" @default.
• W2022950239 hasPublicationYear "2005" @default.
• W2022950239 type Work @default.
• W2022950239 sameAs 2022950239 @default.
• W2022950239 citedByCount "48" @default.
• W2022950239 countsByYear W20229502392012 @default.
• W2022950239 countsByYear W20229502392013 @default.
• W2022950239 countsByYear W20229502392014 @default.
• W2022950239 countsByYear W20229502392015 @default.
• W2022950239 countsByYear W20229502392016 @default.
• W2022950239 countsByYear W20229502392017 @default.
• W2022950239 countsByYear W20229502392018 @default.
• W2022950239 countsByYear W20229502392019 @default.
• W2022950239 countsByYear W20229502392020 @default.
• W2022950239 countsByYear W20229502392021 @default.
• W2022950239 countsByYear W20229502392022 @default.
• W2022950239 crossrefType "journal-article" @default.
• W2022950239 hasAuthorship W2022950239A5005883374 @default.
• W2022950239 hasAuthorship W2022950239A5009690319 @default.
• W2022950239 hasAuthorship W2022950239A5018063097 @default.
• W2022950239 hasAuthorship W2022950239A5020634099 @default.
• W2022950239 hasAuthorship W2022950239A5023240519 @default.
• W2022950239 hasAuthorship W2022950239A5026924357 @default.
• W2022950239 hasAuthorship W2022950239A5029662334 @default.
• W2022950239 hasAuthorship W2022950239A5032097008 @default.
• W2022950239 hasAuthorship W2022950239A5041587646 @default.
• W2022950239 hasAuthorship W2022950239A5046551226 @default.
• W2022950239 hasAuthorship W2022950239A5054128852 @default.
• W2022950239 hasAuthorship W2022950239A5057848962 @default.
• W2022950239 hasAuthorship W2022950239A5072188738 @default.

• next