FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022952220> ?p ?o ?g. }

• W2022952220 abstract "The efflux transport of oestrone-3-sulphate, a steroid hormone sulphate, across the blood-cerebrospinal fluid barrier has been examined following its intracerebroventricular administration. [3H]Oestrone-3-sulphate was eliminated from cerebrospinal fluid (CSF) with an apparent efflux clearance of 205 microL min(-1) per rat. There was 25% of unmetabolized [3H]oestrone-3-sulphate in the plasma 5 min after intracerebroventricular administration, indicating that at least a part of [3H]oestrone-3-sulphate is transported from CSF to the circulating blood across the blood-CSF barrier. This efflux transport was inhibited by co-administration of excess oestrone-3-sulphate (25 mM 10 microL = 0.25 micromol) into rat cerebral ventricle. To characterize the oestrone-3-sulphate transport process, an in-vitro uptake experiment was performed using isolated rat choroid plexus. Oestrone-3-sulphate uptake by isolated rat choroid plexus was found to be a saturable process with a Michaelis-Menten constant (Km) of 18.1 +/- 6.3 microM, and a maximum uptake rate (Vmax) of 48.0 +/- 15.1 pmol min(-1) microL(-1) of tissue. The oestrone-3-sulphate transport process was temperature dependent and was inhibited by metabolic inhibitors such as 2,4-dinitrophenol and rotenone, suggesting an energy dependence. This uptake process was also inhibited by steroid hormone sulphates (1 mM dehydroepiandrosterone sulphate and 1 mM oestrone sulphate), bile acids (1 mM taurocholic acid and 1 mM cholic acid) and organic anions (1 mM sulphobromophthalein and 1 mM phenolsulphonphthalein), whereas 1 mM p-aminohippuric acid, 1 mM p-nitrophenol sulphate, 0.1 mM methotrexate and the cardiac glycoside, 2.5 microM digoxin, had little effect. In conclusion, these results provide evidence that oestrone-3-sulphate is transported from CSF to the circulating blood across the blood-CSF barrier via a carrier-mediated efflux transport system." @default.
• W2022952220 created "2016-06-24" @default.
• W2022952220 creator A5005995886 @default.
• W2022952220 creator A5023268099 @default.
• W2022952220 creator A5026158271 @default.
• W2022952220 creator A5027984186 @default.
• W2022952220 creator A5042102637 @default.
• W2022952220 date "2000-03-01" @default.
• W2022952220 modified "2023-10-05" @default.
• W2022952220 title "In-vivo and In-vitro Evidence of a Carrier-mediated Efflux Transport System for Oestrone-3-sulphate across the Blood-Cerebrospinal Fluid Barrier" @default.
• W2022952220 cites W1976416615 @default.
• W2022952220 cites W1998275215 @default.
• W2022952220 cites W2000076987 @default.
• W2022952220 cites W2015688073 @default.
• W2022952220 cites W2016629748 @default.
• W2022952220 cites W2040436786 @default.
• W2022952220 cites W2040683695 @default.
• W2022952220 cites W2047099953 @default.
• W2022952220 cites W2055776950 @default.
• W2022952220 cites W2060348672 @default.
• W2022952220 cites W2067650742 @default.
• W2022952220 cites W2071101614 @default.
• W2022952220 cites W2087213057 @default.
• W2022952220 cites W2087526401 @default.
• W2022952220 cites W2088776629 @default.
• W2022952220 cites W2111746054 @default.
• W2022952220 cites W2125402020 @default.
• W2022952220 cites W2192325536 @default.
• W2022952220 cites W2414288728 @default.
• W2022952220 cites W70644712 @default.
• W2022952220 doi "https://doi.org/10.1211/0022357001773968" @default.
• W2022952220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10757415" @default.
• W2022952220 hasPublicationYear "2000" @default.
• W2022952220 type Work @default.
• W2022952220 sameAs 2022952220 @default.
• W2022952220 citedByCount "26" @default.
• W2022952220 countsByYear W20229522202015 @default.
• W2022952220 countsByYear W20229522202016 @default.
• W2022952220 countsByYear W20229522202018 @default.
• W2022952220 countsByYear W20229522202019 @default.
• W2022952220 countsByYear W20229522202020 @default.
• W2022952220 crossrefType "journal-article" @default.
• W2022952220 hasAuthorship W2022952220A5005995886 @default.
• W2022952220 hasAuthorship W2022952220A5023268099 @default.
• W2022952220 hasAuthorship W2022952220A5026158271 @default.
• W2022952220 hasAuthorship W2022952220A5027984186 @default.
• W2022952220 hasAuthorship W2022952220A5042102637 @default.
• W2022952220 hasBestOaLocation W20229522201 @default.
• W2022952220 hasConcept C121332964 @default.
• W2022952220 hasConcept C126322002 @default.
• W2022952220 hasConcept C134018914 @default.
• W2022952220 hasConcept C150903083 @default.
• W2022952220 hasConcept C178790620 @default.
• W2022952220 hasConcept C185544564 @default.
• W2022952220 hasConcept C185592680 @default.
• W2022952220 hasConcept C200082930 @default.
• W2022952220 hasConcept C207001950 @default.
• W2022952220 hasConcept C2776538271 @default.
• W2022952220 hasConcept C2776769776 @default.
• W2022952220 hasConcept C2778402981 @default.
• W2022952220 hasConcept C2778656385 @default.
• W2022952220 hasConcept C2779133857 @default.
• W2022952220 hasConcept C2779399885 @default.
• W2022952220 hasConcept C2779651940 @default.
• W2022952220 hasConcept C2780000105 @default.
• W2022952220 hasConcept C2780480987 @default.
• W2022952220 hasConcept C529278444 @default.
• W2022952220 hasConcept C537181965 @default.
• W2022952220 hasConcept C55493867 @default.
• W2022952220 hasConcept C62538594 @default.
• W2022952220 hasConcept C71315377 @default.
• W2022952220 hasConcept C71924100 @default.
• W2022952220 hasConcept C86803240 @default.
• W2022952220 hasConceptScore W2022952220C121332964 @default.
• W2022952220 hasConceptScore W2022952220C126322002 @default.
• W2022952220 hasConceptScore W2022952220C134018914 @default.
• W2022952220 hasConceptScore W2022952220C150903083 @default.
• W2022952220 hasConceptScore W2022952220C178790620 @default.
• W2022952220 hasConceptScore W2022952220C185544564 @default.
• W2022952220 hasConceptScore W2022952220C185592680 @default.
• W2022952220 hasConceptScore W2022952220C200082930 @default.
• W2022952220 hasConceptScore W2022952220C207001950 @default.
• W2022952220 hasConceptScore W2022952220C2776538271 @default.
• W2022952220 hasConceptScore W2022952220C2776769776 @default.
• W2022952220 hasConceptScore W2022952220C2778402981 @default.
• W2022952220 hasConceptScore W2022952220C2778656385 @default.
• W2022952220 hasConceptScore W2022952220C2779133857 @default.
• W2022952220 hasConceptScore W2022952220C2779399885 @default.
• W2022952220 hasConceptScore W2022952220C2779651940 @default.
• W2022952220 hasConceptScore W2022952220C2780000105 @default.
• W2022952220 hasConceptScore W2022952220C2780480987 @default.
• W2022952220 hasConceptScore W2022952220C529278444 @default.
• W2022952220 hasConceptScore W2022952220C537181965 @default.
• W2022952220 hasConceptScore W2022952220C55493867 @default.
• W2022952220 hasConceptScore W2022952220C62538594 @default.
• W2022952220 hasConceptScore W2022952220C71315377 @default.
• W2022952220 hasConceptScore W2022952220C71924100 @default.
• W2022952220 hasConceptScore W2022952220C86803240 @default.
• W2022952220 hasLocation W20229522201 @default.
• W2022952220 hasLocation W20229522202 @default.

• next