FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022952808> ?p ?o ?g. }

• W2022952808 endingPage "24" @default.
• W2022952808 startingPage "13" @default.
• W2022952808 abstract "Lovastatin, an inhibitor of protein prenylation, was reported to inhibit DNA synthesis and induce apoptosis in cultured cells. This report describes the morphological consequences of lovastatin treatment. Lovastatin (50 microM) induced mesangial cell rounding and disassembly of actin stress fibers within 24 to 48 h. After 48 to 72 h of lovastatin treatment, the cells detached from the substratum and underwent apoptotic cell death as evidenced by condensed nuclear chromatin, nuclear fragmentation, cell blebbing and decrease in cell size. Time lapse cinematography revealed that lovastatin caused cell rounding by either inhibiting cytokinesis or cell spreading following cytokinesis. Lovastatin-induced cell rounding, detachment, and apoptosis were dependent upon cell proliferation. These effects were prevented by serum deprivation to inhibit cell proliferation or by plating cells at densities which resulted in contact inhibition of cell growth. Lovastatin-induced mesangial cell rounding and apoptosis were also prevented by the inclusion of the isoprenoids all-trans-farnesol or all-trans-geranylgeraniol in the incubation medium. These results indicate that the effects of lovastatin were mediated by inhibition of protein isoprenylation because exogenous all-trans-geranylgeraniol can be used only in protein prenylation. The small GTP-binding protein RhoA, which may be important for cell spreading and cytokinesis, accumulated in the cytosol following treatment with lovastatin, suggestive of its inactivation. This effect was also prevented by the inclusion of either farnesol or geranylgeraniol in the incubation medium. Thus, lovastatin-induced apoptosis in mesangial cells occurs by interfering with prenylation dependent mitotic and post-mitotic events." @default.
• W2022952808 created "2016-06-24" @default.
• W2022952808 creator A5041650308 @default.
• W2022952808 creator A5044439293 @default.
• W2022952808 creator A5047080204 @default.
• W2022952808 creator A5066025297 @default.
• W2022952808 creator A5074579464 @default.
• W2022952808 creator A5078569994 @default.
• W2022952808 creator A5081985982 @default.
• W2022952808 date "1997-10-01" @default.
• W2022952808 modified "2023-09-26" @default.
• W2022952808 title "Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells" @default.
• W2022952808 cites W1236053900 @default.
• W2022952808 cites W1489400525 @default.
• W2022952808 cites W1517546728 @default.
• W2022952808 cites W1624592313 @default.
• W2022952808 cites W1805425496 @default.
• W2022952808 cites W1905736667 @default.
• W2022952808 cites W1949772429 @default.
• W2022952808 cites W1979232159 @default.
• W2022952808 cites W1980865411 @default.
• W2022952808 cites W1982623307 @default.
• W2022952808 cites W1992055378 @default.
• W2022952808 cites W2004191401 @default.
• W2022952808 cites W2010028742 @default.
• W2022952808 cites W2014599776 @default.
• W2022952808 cites W2027810531 @default.
• W2022952808 cites W2032621682 @default.
• W2022952808 cites W2033995139 @default.
• W2022952808 cites W2048641369 @default.
• W2022952808 cites W2052853635 @default.
• W2022952808 cites W2056942156 @default.
• W2022952808 cites W2071124826 @default.
• W2022952808 cites W2093944336 @default.
• W2022952808 cites W2101480539 @default.
• W2022952808 cites W2136685915 @default.
• W2022952808 cites W2144781186 @default.
• W2022952808 cites W2150102283 @default.
• W2022952808 cites W2157138732 @default.
• W2022952808 cites W2159695799 @default.
• W2022952808 cites W2165297096 @default.
• W2022952808 doi "https://doi.org/10.1016/s0167-4889(97)00091-8" @default.
• W2022952808 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9398081" @default.
• W2022952808 hasPublicationYear "1997" @default.
• W2022952808 type Work @default.
• W2022952808 sameAs 2022952808 @default.
• W2022952808 citedByCount "60" @default.
• W2022952808 countsByYear W20229528082012 @default.
• W2022952808 countsByYear W20229528082013 @default.
• W2022952808 countsByYear W20229528082014 @default.
• W2022952808 countsByYear W20229528082016 @default.
• W2022952808 countsByYear W20229528082021 @default.
• W2022952808 crossrefType "journal-article" @default.
• W2022952808 hasAuthorship W2022952808A5041650308 @default.
• W2022952808 hasAuthorship W2022952808A5044439293 @default.
• W2022952808 hasAuthorship W2022952808A5047080204 @default.
• W2022952808 hasAuthorship W2022952808A5066025297 @default.
• W2022952808 hasAuthorship W2022952808A5074579464 @default.
• W2022952808 hasAuthorship W2022952808A5078569994 @default.
• W2022952808 hasAuthorship W2022952808A5081985982 @default.
• W2022952808 hasBestOaLocation W20229528081 @default.
• W2022952808 hasConcept C1491633281 @default.
• W2022952808 hasConcept C181199279 @default.
• W2022952808 hasConcept C190283241 @default.
• W2022952808 hasConcept C2778163477 @default.
• W2022952808 hasConcept C2778359262 @default.
• W2022952808 hasConcept C2779247237 @default.
• W2022952808 hasConcept C2780940807 @default.
• W2022952808 hasConcept C29537977 @default.
• W2022952808 hasConcept C45472230 @default.
• W2022952808 hasConcept C55493867 @default.
• W2022952808 hasConcept C57790582 @default.
• W2022952808 hasConcept C62112901 @default.
• W2022952808 hasConcept C85813293 @default.
• W2022952808 hasConcept C86803240 @default.
• W2022952808 hasConcept C93304396 @default.
• W2022952808 hasConcept C95444343 @default.
• W2022952808 hasConceptScore W2022952808C1491633281 @default.
• W2022952808 hasConceptScore W2022952808C181199279 @default.
• W2022952808 hasConceptScore W2022952808C190283241 @default.
• W2022952808 hasConceptScore W2022952808C2778163477 @default.
• W2022952808 hasConceptScore W2022952808C2778359262 @default.
• W2022952808 hasConceptScore W2022952808C2779247237 @default.
• W2022952808 hasConceptScore W2022952808C2780940807 @default.
• W2022952808 hasConceptScore W2022952808C29537977 @default.
• W2022952808 hasConceptScore W2022952808C45472230 @default.
• W2022952808 hasConceptScore W2022952808C55493867 @default.
• W2022952808 hasConceptScore W2022952808C57790582 @default.
• W2022952808 hasConceptScore W2022952808C62112901 @default.
• W2022952808 hasConceptScore W2022952808C85813293 @default.
• W2022952808 hasConceptScore W2022952808C86803240 @default.
• W2022952808 hasConceptScore W2022952808C93304396 @default.
• W2022952808 hasConceptScore W2022952808C95444343 @default.
• W2022952808 hasIssue "1" @default.
• W2022952808 hasLocation W20229528081 @default.
• W2022952808 hasLocation W20229528082 @default.
• W2022952808 hasOpenAccess W2022952808 @default.
• W2022952808 hasPrimaryLocation W20229528081 @default.

• next