FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022954161> ?p ?o ?g. }

• W2022954161 endingPage "1106" @default.
• W2022954161 startingPage "1100" @default.
• W2022954161 abstract "No AccessJournal of UrologyInvestigative Urology1 Sep 2011Male Rodent Genital Tract Infection With Chlamydia Muridarum: Persistence in the Prostate Gland That Triggers Self-Immune Reactions in Genetically Susceptible Hosts Juan Pablo Mackern-Oberti, Ruben Dario Motrich, Maria Laura Breser, Hugo Cejas, Cecilia Cuffini, Mariana Maccioni, and Virginia Elena Rivero Juan Pablo Mackern-ObertiJuan Pablo Mackern-Oberti Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author , Ruben Dario MotrichRuben Dario Motrich Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author , Maria Laura BreserMaria Laura Breser Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author , Hugo CejasHugo Cejas Hospital Nuestra Señora de la Misericordia, III Cátedra de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author , Cecilia CuffiniCecilia Cuffini Instituto de Virología “J. M. Vanella”, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author , Mariana MaccioniMariana Maccioni Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author , and Virginia Elena RiveroVirginia Elena Rivero Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.04.086AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated Chlamydia trachomatis infection and its pathogenic consequences in the male rodent genital tract. Materials and Methods: Male rats were inoculated in the meatal urethra with Chlamydia muridarum. We sought bacterial DNA at early and late times after inoculation in different parts of the male genital tract. Histological alterations and the immune response against prostate antigens were analyzed. Results: Male rats showed ascending infection with wide dissemination of bacteria in the genital tract at an early time point after inoculation. At later stages bacteria persisted only in some parts of the genital tract and in the prostate gland. C. muridarum was also detected in semen in a high proportion of rats irrespective of an acute or chronic stage of infection. Histological alterations that accompanied C. muridarum were especially observed in the prostate and mainly composed of CD3+ cell infiltration. Positive humoral and cellular responses against prostate antigens were noted in a considerable number of infected rats. NOD mice, an autoimmune, prostatitis prone strain, showed a similar pattern with C. muridarum in the prostate of 100% of infected mice, which was again accompanied by mononuclear cell infiltration and antibodies against prostate antigens at early and late times after inoculation. Conclusions: Results reveal that C. muridarum infects the male rodent genitourinary tract with special persistence in the prostate gland, where it causes chronic inflammation that in turn may act as a trigger factor for self-immune reactions in susceptible hosts. References 1 : Genital Chlamydia trachomatis infections. Clin Microbiol Infect2009; 15: 4. Google Scholar 2 : Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine. Nat Rev Immunol2005; 5: 149. Google Scholar 3 : Immunity to murine chlamydial genital infection. Infect Immun2002; 70: 2741. Google Scholar 4 : Male infertility and genital chlamydial infection: victim or perpetrator?. Andrologia2003; 35: 209. Google Scholar 5 : Role of Chlamydia trachomatis in epididymitis. Part I: direct and serologic diagnosis. Med Sci Monit2000; 6: 1113. Google Scholar 6 : Male genital tract chlamydial infection: implications for pathology and infertility. Biol Reprod2008; 79: 180. Google Scholar 7 : Symptomatic urethritis is more prevalent in men infected with Mycoplasma genitalium than with Chlamydia trachomatis. Sex Transm Infect2004; 80: 289. Google Scholar 8 : Chlamydia trachomatis occurrence and its impact on sperm quality in chronic prostatitis patients. J Infect2006; 53: 175. Google Scholar 9 : Chlamydial infections and prostatitis in men. BJU Int2006; 97: 687. Google Scholar 10 : Chronic prostatitis: Charlottesville to Seattle. J Urol2004; 172: 2557. Link, Google Scholar 11 : Susceptibility of prostate epithelial cells to Chlamydia muridarum infection and their role in innate immunity by recruitment of intracellular Toll-like receptors 4 and 2 and MyD88 to the inclusion. Infect Immun2006; 74: 6973. Google Scholar 12 : Effects of autoimmunity to the prostate on the fertility of the male rat. Fertil Steril2009; 91: 2273. Google Scholar 13 : Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection. Infect Immun2004; 72: 1019. Google Scholar 14 : Characterization of the humoral immune response to Chlamydia outer membrane protein 2 in chlamydial infection. Clin Diagn Lab Immunol2003; 10: 103. Google Scholar 15 : Pathogenic consequences in semen quality of an autoimmune response against the prostate gland: from animal models to human disease. J Immunol2006; 177: 957. Google Scholar 16 : Prostatein (or rat prostatic steroid binding protein) is a major autoantigen in experimental autoimmune prostatitis. Clin Exp Immunol1998; 112: 159. Google Scholar 17 : Autoimmune prostatitis: state of the art. Scand J Immunol2007; 66: 217. Google Scholar 18 : Experimental rodent models of prostatitis: limitations and potential. Prostate Cancer Prostatic Dis2007; 10: 15. Google Scholar 19 : Cellular immunity and Chlamydia genital infection: induction, recruitment, and effector mechanisms. Int Rev Immunol2003; 22: 3. Google Scholar 20 : Duration of untreated genital infections with chlamydia trachomatis: a review of the literature. Sex Transm Dis2000; 27: 329. Google Scholar 21 : Local host response to chlamydial urethral infection in male guinea pigs. Infect Immun2010; 78: 1670. Google Scholar 22 : New murine model for the study of Chlamydia trachomatis genitourinary tract infections in males. Infect Immun2004; 72: 4210. Google Scholar 23 : Experimental genital tract infection with Chlamydia psittaci (GPIC agent) in male rats. Infection1998; 26: 126. Google Scholar 24 Taylor-Robinson D, Purcell RH, London WT et al: Microbiological, serological, and histopathological features of experimental Chlamydia trachomatis urethritis in chimpanzees. Br J Vener Dis 57: 36. Google Scholar 25 : Cystitis associated with chlamydial infection of the genital tract in male guinea pigs. Sex Transm Dis1981; 8: 203. Google Scholar 26 : Experimental epididymitis and urethritis in grivet monkeys provoked by Chlamydia trachomatis. Fertil Steril1980; 34: 275. Google Scholar 27 : Interaction of Chlamydia trachomatis serovar E with male genital tract epithelium results in secretion of proinflammatory cytokines. J Med Microbiol2007; 56: 1025. Google Scholar 28 : Infections and autoimmunity—friends or foes?. Trends Immunol2009; 30: 409. Google Scholar 29 : Chlamydia trachomatis infection and anti-Hsp60 immunity: the two sides of the coin. PLoS Pathog2009; 200: e1000552. Google Scholar 30 : Molecular mimicry and horror autotoxicus: do chlamydial infections elicit autoimmunity?. Expert Rev Mol Med2006; 30: 1. Google Scholar © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byMotrich R, Sanchez L, Maccioni M, Mackern-Oberti J and Rivero V (2018) Male Rat Genital Tract Infection With Chlamydia Muridarum has No Significant Consequence on Male FertilityJournal of Urology, VOL. 187, NO. 5, (1911-1917), Online publication date: 1-May-2012. Volume 186Issue 3September 2011Page: 1100-1106 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.KeywordsprostatitisRodentiaprostateChlamydia trachomatisautoimmunityAcknowledgmentsC. muridarum MoPn was provided by K. H. Ramsey, United States of America. Recombinant MBP-MOMP fusion protein was provided by Kenneth W. Beagley, University of Newcastle, Newcastle, New South Wales, Australia. Plasmid coding for OMP2 was provided by Prof. J. S. H. Gaston, Addenbrooke's Hospital, Cambridge, United Kingdom.MetricsAuthor Information Juan Pablo Mackern-Oberti Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author Ruben Dario Motrich Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author Maria Laura Breser Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author Hugo Cejas Hospital Nuestra Señora de la Misericordia, III Cátedra de Patología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author Cecilia Cuffini Instituto de Virología “J. M. Vanella”, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author Mariana Maccioni Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author Virginia Elena Rivero Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET), Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
• W2022954161 created "2016-06-24" @default.
• W2022954161 creator A5004901117 @default.
• W2022954161 creator A5010145712 @default.
• W2022954161 creator A5014252491 @default.
• W2022954161 creator A5028471273 @default.
• W2022954161 creator A5038998553 @default.
• W2022954161 creator A5065657680 @default.
• W2022954161 creator A5083364929 @default.
• W2022954161 date "2011-09-01" @default.
• W2022954161 modified "2023-10-14" @default.
• W2022954161 title "Male Rodent Genital Tract Infection With Chlamydia Muridarum: Persistence in the Prostate Gland That Triggers Self-Immune Reactions in Genetically Susceptible Hosts" @default.
• W2022954161 cites W1655505626 @default.
• W2022954161 cites W1827067579 @default.
• W2022954161 cites W1963800840 @default.
• W2022954161 cites W1965702884 @default.
• W2022954161 cites W1968961493 @default.
• W2022954161 cites W1988208510 @default.
• W2022954161 cites W1993728065 @default.
• W2022954161 cites W1995814554 @default.
• W2022954161 cites W2001677125 @default.
• W2022954161 cites W2007208883 @default.
• W2022954161 cites W2035498415 @default.
• W2022954161 cites W2036721716 @default.
• W2022954161 cites W2040506176 @default.
• W2022954161 cites W2041361990 @default.
• W2022954161 cites W2061203889 @default.
• W2022954161 cites W2061961165 @default.
• W2022954161 cites W2072768659 @default.
• W2022954161 cites W2083970858 @default.
• W2022954161 cites W2094893670 @default.
• W2022954161 cites W2095882628 @default.
• W2022954161 cites W2101612832 @default.
• W2022954161 cites W2102917591 @default.
• W2022954161 cites W2107873136 @default.
• W2022954161 cites W2118459600 @default.
• W2022954161 cites W2157450958 @default.
• W2022954161 cites W2159031720 @default.
• W2022954161 cites W2160717239 @default.
• W2022954161 cites W2161898736 @default.
• W2022954161 cites W2419189113 @default.
• W2022954161 doi "https://doi.org/10.1016/j.juro.2011.04.086" @default.
• W2022954161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21783211" @default.
• W2022954161 hasPublicationYear "2011" @default.
• W2022954161 type Work @default.
• W2022954161 sameAs 2022954161 @default.
• W2022954161 citedByCount "21" @default.
• W2022954161 countsByYear W20229541612012 @default.
• W2022954161 countsByYear W20229541612013 @default.
• W2022954161 countsByYear W20229541612014 @default.
• W2022954161 countsByYear W20229541612015 @default.
• W2022954161 countsByYear W20229541612016 @default.
• W2022954161 countsByYear W20229541612017 @default.
• W2022954161 countsByYear W20229541612018 @default.
• W2022954161 countsByYear W20229541612019 @default.
• W2022954161 countsByYear W20229541612020 @default.
• W2022954161 crossrefType "journal-article" @default.
• W2022954161 hasAuthorship W2022954161A5004901117 @default.
• W2022954161 hasAuthorship W2022954161A5010145712 @default.
• W2022954161 hasAuthorship W2022954161A5014252491 @default.
• W2022954161 hasAuthorship W2022954161A5028471273 @default.
• W2022954161 hasAuthorship W2022954161A5038998553 @default.
• W2022954161 hasAuthorship W2022954161A5065657680 @default.
• W2022954161 hasAuthorship W2022954161A5083364929 @default.
• W2022954161 hasConcept C121608353 @default.
• W2022954161 hasConcept C126322002 @default.
• W2022954161 hasConcept C127413603 @default.
• W2022954161 hasConcept C183021626 @default.
• W2022954161 hasConcept C187320778 @default.
• W2022954161 hasConcept C18903297 @default.
• W2022954161 hasConcept C203014093 @default.
• W2022954161 hasConcept C2776235491 @default.
• W2022954161 hasConcept C2778914748 @default.
• W2022954161 hasConcept C2780122209 @default.
• W2022954161 hasConcept C2781009140 @default.
• W2022954161 hasConcept C2991749049 @default.
• W2022954161 hasConcept C2992003382 @default.
• W2022954161 hasConcept C2994355933 @default.
• W2022954161 hasConcept C42407357 @default.
• W2022954161 hasConcept C54355233 @default.
• W2022954161 hasConcept C71924100 @default.
• W2022954161 hasConcept C86803240 @default.
• W2022954161 hasConcept C8891405 @default.
• W2022954161 hasConceptScore W2022954161C121608353 @default.
• W2022954161 hasConceptScore W2022954161C126322002 @default.
• W2022954161 hasConceptScore W2022954161C127413603 @default.
• W2022954161 hasConceptScore W2022954161C183021626 @default.
• W2022954161 hasConceptScore W2022954161C187320778 @default.
• W2022954161 hasConceptScore W2022954161C18903297 @default.
• W2022954161 hasConceptScore W2022954161C203014093 @default.
• W2022954161 hasConceptScore W2022954161C2776235491 @default.
• W2022954161 hasConceptScore W2022954161C2778914748 @default.
• W2022954161 hasConceptScore W2022954161C2780122209 @default.
• W2022954161 hasConceptScore W2022954161C2781009140 @default.
• W2022954161 hasConceptScore W2022954161C2991749049 @default.
• W2022954161 hasConceptScore W2022954161C2992003382 @default.
• W2022954161 hasConceptScore W2022954161C2994355933 @default.
• W2022954161 hasConceptScore W2022954161C42407357 @default.

• next