FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022954400> ?p ?o ?g. }

• W2022954400 endingPage "891" @default.
• W2022954400 startingPage "884" @default.
• W2022954400 abstract "The vitamin E analog γ-tocotrienol (GT3) is a powerful radioprotector. GT3 reduces postradiation vascular peroxynitrite production, an effect dependent on inhibition of hydroxy-methylglutaryl-coenzyme A reductase. Hydroxy-methylglutaryl-coenzyme A reductase inhibitors mediate their pleiotropic effects via endothelial nitric oxide synthase that requires the cofactor tetrahydrobiopterin (BH4). This study investigated the effects of radiation on BH4 bioavailability and of GT3 on BH4 metabolism.Mice were exposed to 8.5 Gy of total body irradiation (TBI). Lung BH4 and total biopterin concentrations were measured 0, 3.5, 7, 14, and 21 days after TBI by use of differential oxidation followed by high-performance liquid chromatography. The effect of exogenous GT3 and BH4 treatment on postradiation vascular oxidative stress and bone marrow colony-forming units were assessed in vivo. The effect of GT3 on endothelial cell apoptosis and endothelial expression of guanosine triphosphate (GTP) cyclohydrolase 1 (GTPCH), GTPCH feedback regulatory protein (GFRP), GFRP transcription, GFRP protein levels, and GFRP-GTPCH protein binding was determined in vitro.Compared with baseline levels, lung BH4 concentrations decreased by 24% at 3.5 days after TBI, an effect that was reversed by GT3. At 14 and 21 days after TBI, compensatory increases in BH4 (58% and 80%, respectively) were observed. Relative to vehicle-treated controls, both GT3 and BH4 supplementation reduced postirradiation vascular peroxynitrite production at 3.5 days (by 66% and 33%, respectively), and BH4 resulted in a 68% increase in bone marrow colony-forming units. GT3 ameliorated endothelial cell apoptosis and reduced endothelial GFRP protein levels and GFRP-GTPCH binding by decreasing transcription of the GFRP gene.BH4 bioavailability is reduced in the early postradiation phase. Exogenous administration of BH4 reduces postirradiation vascular oxidative stress. GT3 potently reduces the expression of GFRP, one of the key regulatory proteins in the BH4 pathway, and may thus exert some of its beneficial effects on postradiation free radical production partly by counteracting the decrease in BH4." @default.
• W2022954400 created "2016-06-24" @default.
• W2022954400 creator A5014015669 @default.
• W2022954400 creator A5046236881 @default.
• W2022954400 creator A5069629718 @default.
• W2022954400 creator A5086818435 @default.
• W2022954400 creator A5088241361 @default.
• W2022954400 creator A5088478491 @default.
• W2022954400 creator A5089053875 @default.
• W2022954400 date "2011-03-01" @default.
• W2022954400 modified "2023-10-18" @default.
• W2022954400 title "Reduction of Radiation-Induced Vascular Nitrosative Stress by the Vitamin E Analog γ-Tocotrienol: Evidence of a Role for Tetrahydrobiopterin" @default.
• W2022954400 cites W124910842 @default.
• W2022954400 cites W149739268 @default.
• W2022954400 cites W1559597940 @default.
• W2022954400 cites W1880335557 @default.
• W2022954400 cites W1964867222 @default.
• W2022954400 cites W1982581996 @default.
• W2022954400 cites W1989731044 @default.
• W2022954400 cites W1990255353 @default.
• W2022954400 cites W1990931414 @default.
• W2022954400 cites W1994064108 @default.
• W2022954400 cites W2009218185 @default.
• W2022954400 cites W2024848503 @default.
• W2022954400 cites W2027983826 @default.
• W2022954400 cites W2044351980 @default.
• W2022954400 cites W2050209774 @default.
• W2022954400 cites W2058145440 @default.
• W2022954400 cites W2060329407 @default.
• W2022954400 cites W2069083293 @default.
• W2022954400 cites W2070071456 @default.
• W2022954400 cites W2076626384 @default.
• W2022954400 cites W2087018994 @default.
• W2022954400 cites W2088341880 @default.
• W2022954400 cites W2089574590 @default.
• W2022954400 cites W2090192963 @default.
• W2022954400 cites W2098331821 @default.
• W2022954400 cites W2103636227 @default.
• W2022954400 cites W2107293885 @default.
• W2022954400 cites W2126560446 @default.
• W2022954400 cites W2132785031 @default.
• W2022954400 cites W2169782569 @default.
• W2022954400 cites W2170791084 @default.
• W2022954400 cites W4247794967 @default.
• W2022954400 cites W49033745 @default.
• W2022954400 doi "https://doi.org/10.1016/j.ijrobp.2010.08.032" @default.
• W2022954400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3023840" @default.
• W2022954400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20950957" @default.
• W2022954400 hasPublicationYear "2011" @default.
• W2022954400 type Work @default.
• W2022954400 sameAs 2022954400 @default.
• W2022954400 citedByCount "56" @default.
• W2022954400 countsByYear W20229544002013 @default.
• W2022954400 countsByYear W20229544002014 @default.
• W2022954400 countsByYear W20229544002015 @default.
• W2022954400 countsByYear W20229544002016 @default.
• W2022954400 countsByYear W20229544002017 @default.
• W2022954400 countsByYear W20229544002018 @default.
• W2022954400 countsByYear W20229544002019 @default.
• W2022954400 countsByYear W20229544002020 @default.
• W2022954400 countsByYear W20229544002021 @default.
• W2022954400 countsByYear W20229544002022 @default.
• W2022954400 countsByYear W20229544002023 @default.
• W2022954400 crossrefType "journal-article" @default.
• W2022954400 hasAuthorship W2022954400A5014015669 @default.
• W2022954400 hasAuthorship W2022954400A5046236881 @default.
• W2022954400 hasAuthorship W2022954400A5069629718 @default.
• W2022954400 hasAuthorship W2022954400A5086818435 @default.
• W2022954400 hasAuthorship W2022954400A5088241361 @default.
• W2022954400 hasAuthorship W2022954400A5088478491 @default.
• W2022954400 hasAuthorship W2022954400A5089053875 @default.
• W2022954400 hasBestOaLocation W20229544002 @default.
• W2022954400 hasConcept C126322002 @default.
• W2022954400 hasConcept C134018914 @default.
• W2022954400 hasConcept C181199279 @default.
• W2022954400 hasConcept C185592680 @default.
• W2022954400 hasConcept C2776145790 @default.
• W2022954400 hasConcept C2776151105 @default.
• W2022954400 hasConcept C2777103536 @default.
• W2022954400 hasConcept C2777451243 @default.
• W2022954400 hasConcept C2777551382 @default.
• W2022954400 hasConcept C2777622882 @default.
• W2022954400 hasConcept C2778004101 @default.
• W2022954400 hasConcept C2778310972 @default.
• W2022954400 hasConcept C2778784160 @default.
• W2022954400 hasConcept C2779384338 @default.
• W2022954400 hasConcept C2780795997 @default.
• W2022954400 hasConcept C2780972559 @default.
• W2022954400 hasConcept C2781449162 @default.
• W2022954400 hasConcept C519581460 @default.
• W2022954400 hasConcept C55493867 @default.
• W2022954400 hasConcept C71924100 @default.
• W2022954400 hasConcept C98274493 @default.
• W2022954400 hasConceptScore W2022954400C126322002 @default.
• W2022954400 hasConceptScore W2022954400C134018914 @default.
• W2022954400 hasConceptScore W2022954400C181199279 @default.
• W2022954400 hasConceptScore W2022954400C185592680 @default.
• W2022954400 hasConceptScore W2022954400C2776145790 @default.

• next