FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022955083> ?p ?o ?g. }

• W2022955083 endingPage "97" @default.
• W2022955083 startingPage "91" @default.
• W2022955083 abstract "The potential application of toxicogenomics to predictive toxicology has been discussed widely, but the utility of the approach remains largely unproven. Using cDNA microarrays, we compared the gene expression profiles produced in mouse lymphoma cells by three genotoxic compounds, hydroxyurea (a carcinogen), p-anisidine (a noncarcinogen), and paclitaxel (carcinogenicity unknown). To minimize the effect of biological variability and technological limitations, quadruplicate observations were made for each compound and a subset of genes yielding reproducible induction/repression was selected for comparison. A method was applied to attach normalized expression data to genes with a low false-discovery rate (<0.1) to yield more confidence regarding differential expression. This analysis identified genotoxicity-specific gene expression. Seven genes were consistently upregulated and 12 downregulated more than 2-fold by the three genotoxic compounds. Using additional genes, the expression pattern induced by the genotoxic noncarcinogen, p-anisidine, was readily distinguished from that associated with the genotoxic carcinogen, hydroxyurea. Comparison of paclitaxel-induced expression data to data for p-anisidine and hydroxyurea suggested that paclitaxel's profile is more similar to the genotoxic noncarcinogen. With further supporting evidence it may be possible to perform large-scale monitoring of gene expression during drug and chemical development that can provide an early warning of potential toxicological responses." @default.
• W2022955083 created "2016-06-24" @default.
• W2022955083 creator A5025552139 @default.
• W2022955083 creator A5039880005 @default.
• W2022955083 creator A5048481601 @default.
• W2022955083 creator A5049015016 @default.
• W2022955083 creator A5056670707 @default.
• W2022955083 creator A5067172393 @default.
• W2022955083 creator A5069667659 @default.
• W2022955083 creator A5085116423 @default.
• W2022955083 creator A5086169686 @default.
• W2022955083 date "2003-01-01" @default.
• W2022955083 modified "2023-09-23" @default.
• W2022955083 title "cDNA microarray gene expression profiling of hydroxyurea, paclitaxel, and p-anisidine, genotoxic compounds with differing tumorigenicity results" @default.
• W2022955083 cites W1651215666 @default.
• W2022955083 cites W1831347542 @default.
• W2022955083 cites W1873367784 @default.
• W2022955083 cites W1941077407 @default.
• W2022955083 cites W1967053372 @default.
• W2022955083 cites W1972962718 @default.
• W2022955083 cites W1977289089 @default.
• W2022955083 cites W1983022394 @default.
• W2022955083 cites W1989468407 @default.
• W2022955083 cites W1990857789 @default.
• W2022955083 cites W1994656104 @default.
• W2022955083 cites W2007032434 @default.
• W2022955083 cites W2011965699 @default.
• W2022955083 cites W2019193439 @default.
• W2022955083 cites W2032325250 @default.
• W2022955083 cites W2053777314 @default.
• W2022955083 cites W2055041189 @default.
• W2022955083 cites W2055915480 @default.
• W2022955083 cites W2064637938 @default.
• W2022955083 cites W2081052815 @default.
• W2022955083 cites W2088230515 @default.
• W2022955083 cites W2089976301 @default.
• W2022955083 cites W2094814371 @default.
• W2022955083 cites W2100668965 @default.
• W2022955083 cites W2114090345 @default.
• W2022955083 cites W2118386638 @default.
• W2022955083 cites W2126136513 @default.
• W2022955083 cites W2131399856 @default.
• W2022955083 cites W2132548616 @default.
• W2022955083 cites W2133410001 @default.
• W2022955083 cites W2142975116 @default.
• W2022955083 cites W2147246240 @default.
• W2022955083 cites W2152931165 @default.
• W2022955083 cites W2218264742 @default.
• W2022955083 cites W2222035013 @default.
• W2022955083 cites W2319767540 @default.
• W2022955083 cites W2327488397 @default.
• W2022955083 cites W4294107304 @default.
• W2022955083 doi "https://doi.org/10.1002/em.10177" @default.
• W2022955083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12929121" @default.
• W2022955083 hasPublicationYear "2003" @default.
• W2022955083 type Work @default.
• W2022955083 sameAs 2022955083 @default.
• W2022955083 citedByCount "27" @default.
• W2022955083 countsByYear W20229550832012 @default.
• W2022955083 countsByYear W20229550832013 @default.
• W2022955083 countsByYear W20229550832015 @default.
• W2022955083 countsByYear W20229550832016 @default.
• W2022955083 countsByYear W20229550832020 @default.
• W2022955083 crossrefType "journal-article" @default.
• W2022955083 hasAuthorship W2022955083A5025552139 @default.
• W2022955083 hasAuthorship W2022955083A5039880005 @default.
• W2022955083 hasAuthorship W2022955083A5048481601 @default.
• W2022955083 hasAuthorship W2022955083A5049015016 @default.
• W2022955083 hasAuthorship W2022955083A5056670707 @default.
• W2022955083 hasAuthorship W2022955083A5067172393 @default.
• W2022955083 hasAuthorship W2022955083A5069667659 @default.
• W2022955083 hasAuthorship W2022955083A5085116423 @default.
• W2022955083 hasAuthorship W2022955083A5086169686 @default.
• W2022955083 hasConcept C104317684 @default.
• W2022955083 hasConcept C114246631 @default.
• W2022955083 hasConcept C121608353 @default.
• W2022955083 hasConcept C150194340 @default.
• W2022955083 hasConcept C153911025 @default.
• W2022955083 hasConcept C178790620 @default.
• W2022955083 hasConcept C18431079 @default.
• W2022955083 hasConcept C185592680 @default.
• W2022955083 hasConcept C186836561 @default.
• W2022955083 hasConcept C187882448 @default.
• W2022955083 hasConcept C2777292972 @default.
• W2022955083 hasConcept C2778959862 @default.
• W2022955083 hasConcept C29730261 @default.
• W2022955083 hasConcept C54355233 @default.
• W2022955083 hasConcept C70721500 @default.
• W2022955083 hasConcept C86803240 @default.
• W2022955083 hasConcept C93231420 @default.
• W2022955083 hasConcept C95371953 @default.
• W2022955083 hasConceptScore W2022955083C104317684 @default.
• W2022955083 hasConceptScore W2022955083C114246631 @default.
• W2022955083 hasConceptScore W2022955083C121608353 @default.
• W2022955083 hasConceptScore W2022955083C150194340 @default.
• W2022955083 hasConceptScore W2022955083C153911025 @default.
• W2022955083 hasConceptScore W2022955083C178790620 @default.
• W2022955083 hasConceptScore W2022955083C18431079 @default.

• next