Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022961049> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2022961049 endingPage "858" @default.
- W2022961049 startingPage "852" @default.
- W2022961049 abstract "A number of arylidene derivatives of alicyclic ketones and some corresponding oximes, oxime esters, and related compounds were prepared as candidate cytotoxic agents. All of the compounds were evaluated against murine L1210 lymphoid leukemia cells. In general, cytotoxicity was greatest with the alpha,beta-unsaturated ketones and diminished with the oximes, and the oxime esters had little or no activity in this screen. When the same compounds were examined in both the in vitro L1210 and P388 leukemia screens, in the majority of cases the L1210 cells were more sensitive to these derivatives. Over half of the compounds prepared were evaluated against approximately 55 human tumors in vitro and showed selective toxicity toward one or more groups of neoplastic diseases, particularly leukemia. Some correlations between structure and bioactivity were discerned. The cytotoxicity screening and stability studies of representative compounds suggested that the ketones, oximes, and oxime esters were stable under the conditions of bioevaluation. X-ray crystallography of four representative compounds revealed structural features associated with cytotoxicity which may be considered in the design of future candidate cytotoxins." @default.
- W2022961049 created "2016-06-24" @default.
- W2022961049 creator A5010576521 @default.
- W2022961049 creator A5016652732 @default.
- W2022961049 creator A5018854907 @default.
- W2022961049 creator A5036853330 @default.
- W2022961049 creator A5048897135 @default.
- W2022961049 creator A5048916756 @default.
- W2022961049 creator A5062016770 @default.
- W2022961049 date "1994-06-01" @default.
- W2022961049 modified "2023-09-23" @default.
- W2022961049 title "Synthesis and Cytotoxic Evaluation of Some Cyclic Arylidene Ketones and Related Oximes, Oxime Esters, and Analogs" @default.
- W2022961049 cites W1976398338 @default.
- W2022961049 cites W2007076334 @default.
- W2022961049 cites W2021137848 @default.
- W2022961049 cites W2073017099 @default.
- W2022961049 cites W2109068447 @default.
- W2022961049 cites W2118174268 @default.
- W2022961049 cites W2122109248 @default.
- W2022961049 cites W2165884308 @default.
- W2022961049 doi "https://doi.org/10.1002/jps.2600830619" @default.
- W2022961049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9120820" @default.
- W2022961049 hasPublicationYear "1994" @default.
- W2022961049 type Work @default.
- W2022961049 sameAs 2022961049 @default.
- W2022961049 citedByCount "22" @default.
- W2022961049 countsByYear W20229610492012 @default.
- W2022961049 countsByYear W20229610492014 @default.
- W2022961049 countsByYear W20229610492015 @default.
- W2022961049 countsByYear W20229610492017 @default.
- W2022961049 countsByYear W20229610492019 @default.
- W2022961049 countsByYear W20229610492020 @default.
- W2022961049 countsByYear W20229610492021 @default.
- W2022961049 crossrefType "journal-article" @default.
- W2022961049 hasAuthorship W2022961049A5010576521 @default.
- W2022961049 hasAuthorship W2022961049A5016652732 @default.
- W2022961049 hasAuthorship W2022961049A5018854907 @default.
- W2022961049 hasAuthorship W2022961049A5036853330 @default.
- W2022961049 hasAuthorship W2022961049A5048897135 @default.
- W2022961049 hasAuthorship W2022961049A5048916756 @default.
- W2022961049 hasAuthorship W2022961049A5062016770 @default.
- W2022961049 hasConcept C109316439 @default.
- W2022961049 hasConcept C178790620 @default.
- W2022961049 hasConcept C185592680 @default.
- W2022961049 hasConcept C202751555 @default.
- W2022961049 hasConcept C203014093 @default.
- W2022961049 hasConcept C206263279 @default.
- W2022961049 hasConcept C2778461978 @default.
- W2022961049 hasConcept C2779469565 @default.
- W2022961049 hasConcept C2779648554 @default.
- W2022961049 hasConcept C2780017796 @default.
- W2022961049 hasConcept C55493867 @default.
- W2022961049 hasConcept C71240020 @default.
- W2022961049 hasConcept C86803240 @default.
- W2022961049 hasConceptScore W2022961049C109316439 @default.
- W2022961049 hasConceptScore W2022961049C178790620 @default.
- W2022961049 hasConceptScore W2022961049C185592680 @default.
- W2022961049 hasConceptScore W2022961049C202751555 @default.
- W2022961049 hasConceptScore W2022961049C203014093 @default.
- W2022961049 hasConceptScore W2022961049C206263279 @default.
- W2022961049 hasConceptScore W2022961049C2778461978 @default.
- W2022961049 hasConceptScore W2022961049C2779469565 @default.
- W2022961049 hasConceptScore W2022961049C2779648554 @default.
- W2022961049 hasConceptScore W2022961049C2780017796 @default.
- W2022961049 hasConceptScore W2022961049C55493867 @default.
- W2022961049 hasConceptScore W2022961049C71240020 @default.
- W2022961049 hasConceptScore W2022961049C86803240 @default.
- W2022961049 hasIssue "6" @default.
- W2022961049 hasLocation W20229610491 @default.
- W2022961049 hasLocation W20229610492 @default.
- W2022961049 hasOpenAccess W2022961049 @default.
- W2022961049 hasPrimaryLocation W20229610491 @default.
- W2022961049 hasRelatedWork W1970533927 @default.
- W2022961049 hasRelatedWork W1973504375 @default.
- W2022961049 hasRelatedWork W1977213462 @default.
- W2022961049 hasRelatedWork W1998968340 @default.
- W2022961049 hasRelatedWork W2022961049 @default.
- W2022961049 hasRelatedWork W2051382479 @default.
- W2022961049 hasRelatedWork W2075505529 @default.
- W2022961049 hasRelatedWork W2156333380 @default.
- W2022961049 hasRelatedWork W2951938206 @default.
- W2022961049 hasRelatedWork W2141663505 @default.
- W2022961049 hasVolume "83" @default.
- W2022961049 isParatext "false" @default.
- W2022961049 isRetracted "false" @default.
- W2022961049 magId "2022961049" @default.
- W2022961049 workType "article" @default.