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- W2022962519 endingPage "117" @default.
- W2022962519 startingPage "111" @default.
- W2022962519 abstract "The cysteine-rich secretory proteins (CRISPs) are a subgroup of the CRISP, antigen 5 and Pr-1 (CAP) protein superfamily, and are found only in vertebrates. They show a strong expression bias to the mammalian male reproductive tract and the venom of poisonous reptiles. Within the male reproductive tract CRISPs have been implicated in many aspects of male germ cell biology spanning haploid germ cell development, epididymal maturation, capacitation, motility and the actual processes of fertilization. At a structural level, CRISPs are composed of two domains, a CAP domain, which has been implicated in cell-cell adhesion, and a CRISP domain, which has been shown to regulate several classes of ion channels across multiple species. Herein, we will review the current literature on the role of CRISPs in male fertility, and by inference to related non-mammalian protein, infer potential biochemical functions." @default.
- W2022962519 created "2016-06-24" @default.
- W2022962519 creator A5010394143 @default.
- W2022962519 creator A5028880673 @default.
- W2022962519 creator A5044921136 @default.
- W2022962519 date "2010-10-25" @default.
- W2022962519 modified "2023-09-27" @default.
- W2022962519 title "The role of cysteine-rich secretory proteins in male fertility" @default.
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- W2022962519 doi "https://doi.org/10.1038/aja.2010.77" @default.
- W2022962519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3739402" @default.
- W2022962519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20972450" @default.
- W2022962519 hasPublicationYear "2010" @default.
- W2022962519 type Work @default.