FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022962956> ?p ?o ?g. }

• W2022962956 endingPage "114" @default.
• W2022962956 startingPage "109" @default.
• W2022962956 abstract "Background Infection is an infrequent but serious complication of prosthetic joint surgery. These infections will usually not clear until the implant is removed and re-implantation has a high failure rate, especially when Pseudomonas aeruginosa is involved.Material and methods We examined Pseudomonas aeruginosa biofilm formation on plain and gentami-cin-loaded bone cement with confocal scanning laser microscopy (CSLM). Two different stains were applied in order to visualize and quantify the distribution of bacterial cells and extracellular polymeric substances (slime) from the bone cement surface to the top of the biofilm. Staining with LIVE/DEAD viability stain differentiated between live and dead bacteria within the biofilm, and slime production was evaluated after staining with Calcofluor white.Results CSLM showed that the biofilm was a nonuniform structure of variable thickness, with differences in local bacterial cell and slime densities. Incorporation of gentamicin in bone cement resulted in a 44% reduction in bacterial viability, while the slime density increased significantly. In addition, conventional plate counting showed the development of small-colony variants on gentamicin-loaded bone cement with a decreased sensitivity for gentamicin (MIC: 8 mg/L), as compared with normal-sized colonies taken from plain and gentamicin-loaded bone cement (MIC: 3 mg/L). The enhanced slime production on antibiotic-loaded bone cement, together with the formation of small-colony variants, resulted in decreased susceptibility to antibiotics—probably concomitant with the onset of persistent and relapsing infections.Interpretation In the clinical situation, our findings help to explain the frequent re-implantation failure of joint replacements infected with P. aeruginosa when the procedure has been performed using antibiotic-loaded bone cement." @default.
• W2022962956 created "2016-06-24" @default.
• W2022962956 creator A5036422165 @default.
• W2022962956 creator A5042736566 @default.
• W2022962956 creator A5047737595 @default.
• W2022962956 creator A5054242277 @default.
• W2022962956 creator A5081166607 @default.
• W2022962956 date "2005-01-01" @default.
• W2022962956 modified "2023-09-27" @default.
• W2022962956 title "<i>Pseudomonas aeruginosa</i>biofilm formation and slime excretion on antibiotic-loaded bone cement" @default.
• W2022962956 cites W1802421655 @default.
• W2022962956 cites W1933776854 @default.
• W2022962956 cites W1979074882 @default.
• W2022962956 cites W1979457189 @default.
• W2022962956 cites W1999277244 @default.
• W2022962956 cites W2003074151 @default.
• W2022962956 cites W2003343094 @default.
• W2022962956 cites W2009574119 @default.
• W2022962956 cites W2058063161 @default.
• W2022962956 cites W2073735874 @default.
• W2022962956 cites W2079130094 @default.
• W2022962956 cites W2111847013 @default.
• W2022962956 cites W2131727615 @default.
• W2022962956 cites W2144440398 @default.
• W2022962956 cites W2149586621 @default.
• W2022962956 cites W2162832512 @default.
• W2022962956 cites W2170395961 @default.
• W2022962956 cites W2492483684 @default.
• W2022962956 cites W2989056776 @default.
• W2022962956 cites W4301258230 @default.
• W2022962956 cites W73108703 @default.
• W2022962956 doi "https://doi.org/10.1080/00016470510030427" @default.
• W2022962956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15788318" @default.
• W2022962956 hasPublicationYear "2005" @default.
• W2022962956 type Work @default.
• W2022962956 sameAs 2022962956 @default.
• W2022962956 citedByCount "74" @default.
• W2022962956 countsByYear W20229629562012 @default.
• W2022962956 countsByYear W20229629562013 @default.
• W2022962956 countsByYear W20229629562014 @default.
• W2022962956 countsByYear W20229629562015 @default.
• W2022962956 countsByYear W20229629562016 @default.
• W2022962956 countsByYear W20229629562017 @default.
• W2022962956 countsByYear W20229629562018 @default.
• W2022962956 countsByYear W20229629562019 @default.
• W2022962956 countsByYear W20229629562020 @default.
• W2022962956 countsByYear W20229629562021 @default.
• W2022962956 countsByYear W20229629562022 @default.
• W2022962956 countsByYear W20229629562023 @default.
• W2022962956 crossrefType "journal-article" @default.
• W2022962956 hasAuthorship W2022962956A5036422165 @default.
• W2022962956 hasAuthorship W2022962956A5042736566 @default.
• W2022962956 hasAuthorship W2022962956A5047737595 @default.
• W2022962956 hasAuthorship W2022962956A5054242277 @default.
• W2022962956 hasAuthorship W2022962956A5081166607 @default.
• W2022962956 hasBestOaLocation W20229629562 @default.
• W2022962956 hasConcept C159985019 @default.
• W2022962956 hasConcept C192562407 @default.
• W2022962956 hasConcept C2775832221 @default.
• W2022962956 hasConcept C2777637488 @default.
• W2022962956 hasConcept C2778891590 @default.
• W2022962956 hasConcept C501593827 @default.
• W2022962956 hasConcept C523546767 @default.
• W2022962956 hasConcept C523993062 @default.
• W2022962956 hasConcept C54355233 @default.
• W2022962956 hasConcept C58123911 @default.
• W2022962956 hasConcept C71924100 @default.
• W2022962956 hasConcept C86803240 @default.
• W2022962956 hasConcept C89423630 @default.
• W2022962956 hasConceptScore W2022962956C159985019 @default.
• W2022962956 hasConceptScore W2022962956C192562407 @default.
• W2022962956 hasConceptScore W2022962956C2775832221 @default.
• W2022962956 hasConceptScore W2022962956C2777637488 @default.
• W2022962956 hasConceptScore W2022962956C2778891590 @default.
• W2022962956 hasConceptScore W2022962956C501593827 @default.
• W2022962956 hasConceptScore W2022962956C523546767 @default.
• W2022962956 hasConceptScore W2022962956C523993062 @default.
• W2022962956 hasConceptScore W2022962956C54355233 @default.
• W2022962956 hasConceptScore W2022962956C58123911 @default.
• W2022962956 hasConceptScore W2022962956C71924100 @default.
• W2022962956 hasConceptScore W2022962956C86803240 @default.
• W2022962956 hasConceptScore W2022962956C89423630 @default.
• W2022962956 hasIssue "1" @default.
• W2022962956 hasLocation W20229629561 @default.
• W2022962956 hasLocation W20229629562 @default.
• W2022962956 hasLocation W20229629563 @default.
• W2022962956 hasOpenAccess W2022962956 @default.
• W2022962956 hasPrimaryLocation W20229629561 @default.
• W2022962956 hasRelatedWork W1968602861 @default.
• W2022962956 hasRelatedWork W2145233439 @default.
• W2022962956 hasRelatedWork W2731516015 @default.
• W2022962956 hasRelatedWork W2935219258 @default.
• W2022962956 hasRelatedWork W3032865068 @default.
• W2022962956 hasRelatedWork W3081907533 @default.
• W2022962956 hasRelatedWork W3197765279 @default.
• W2022962956 hasRelatedWork W4200194760 @default.
• W2022962956 hasRelatedWork W4246694857 @default.
• W2022962956 hasRelatedWork W4285987862 @default.

• next