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- W2022963567 abstract "It has been postulated that the cytolytic action exerted by glucocorticoids on lymphoid cells could be the consequence of a steroid-induced accumulation within the cells of cytotoxic compounds, namely free fatty acids. In order to investigate this possibility we have determined in isolated mouse thymocytes the action of dexamethasone on cell fatty acid content and on both fatty acid turnover and de novo fatty acid synthesis. Our results show that neither fatty acid content nor fatty acid turnover is significantly modified during in vitro incubation in the presence of steroid. In addition, dexamethasone induces a marked inhibition of the incorporation of [ 3 H]-acetate into lipids, including free fatty acid pools. It appears therefore that, in vitro , the cytolytic effect of glucocorticoids is not due to free fatty acid accumulation. However, in vivo injection of hydrocortisone leads to an increase of fatty acid content within the whole thymus gland. As we have also demonstrated a cytotoxic action of exogenous fatty acids on isolated thymocytes, we suggest that steroids could exert an indirect action on lymphoid cells by promoting fatty acid release from other sources." @default.
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- W2022963567 date "1981-09-01" @default.
- W2022963567 modified "2023-10-18" @default.
- W2022963567 title "Effect of dexamethasone on non-esterified fatty acid metabolism in isolated mouse thymocytes" @default.
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- W2022963567 doi "https://doi.org/10.1016/0022-4731(81)90229-6" @default.
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