FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022963978> ?p ?o ?g. }

• W2022963978 endingPage "270" @default.
• W2022963978 startingPage "256" @default.
• W2022963978 abstract "Studies of type 1 diabetes indicate that autoaggressive T cells specific to beta-cell antigens, reaching certain threshold levels, may play critical roles in the development of the disease. Flow cytometric analyses found that autoreactive T-cell lines from patients induced by beta-cell antigens consisted of four major subsets (CD4(+)CD56(-), CD4(+)CD56(+), CD8(+)CD56(-), and CD8(+)CD56(+)) and that CD56(+) NKT cells might be derived from CD56(-) T cells. Moreover, the proportion of CD56(+) NKT cells in the T-cell lines was influenced by time course of repeated antigen stimulation. beta-cell antigen-specific CD56(+) NKT (CD4(+) or CD8(+)) cells were more aggressive (HLA-restricted and -unrestricted) effector cells lysing target cells such as K562, Jurkat, P815 plus anti-CD3 antibody, and autologous B cells sensitized by beta-cell peptides, when compared with their CD56(-) counterparts. beta-cell antigen- specific CD4(+)CD56(+) NKT cells showed non-HLA-restricted cytotoxicity to human beta cells, insulinoma cell line CM, and to islet cell lines TRM-6 and HP62 expressing CD56 but not to four CD56(-) pancreatic cell lines of non- islet origin. The CD4(+)CD56(+) NKT cells showed stronger cytotoxicity to CM, TRM-6 and HP62 cells than did CD4(+)CD56(-) T cells. Moreover, isotope-unlabelled CD56(+) cells and anti-CD56 antibodies were able to inhibit cytotoxicity of CD4(+)CD56(+) NKT to CD56(+) target cells. These results suggest that CD56(+) NKT cells are aggressive cytotoxic cells to beta cells and that CD56 expression might be associated with the aggressiveness of effector T cells and the susceptibility of target cells." @default.
• W2022963978 created "2016-06-24" @default.
• W2022963978 creator A5011828368 @default.
• W2022963978 creator A5021379796 @default.
• W2022963978 creator A5024848629 @default.
• W2022963978 creator A5065048439 @default.
• W2022963978 creator A5087265840 @default.
• W2022963978 date "2002-04-01" @default.
• W2022963978 modified "2023-10-17" @default.
• W2022963978 title "β-cell antigen-specific CD56 + NKT cells from type 1 diabetic patients: autoaggressive effector T cells damage human CD56 + β cells by HLA-restricted and non-HLA-restricted pathways" @default.
• W2022963978 cites W1489090048 @default.
• W2022963978 cites W1521451515 @default.
• W2022963978 cites W1542501019 @default.
• W2022963978 cites W1543295101 @default.
• W2022963978 cites W1556588515 @default.
• W2022963978 cites W1562708299 @default.
• W2022963978 cites W1564959198 @default.
• W2022963978 cites W1594345612 @default.
• W2022963978 cites W1665834499 @default.
• W2022963978 cites W176624560 @default.
• W2022963978 cites W1844093446 @default.
• W2022963978 cites W1946323404 @default.
• W2022963978 cites W1961486822 @default.
• W2022963978 cites W1989131397 @default.
• W2022963978 cites W1989849595 @default.
• W2022963978 cites W1990419792 @default.
• W2022963978 cites W1993381625 @default.
• W2022963978 cites W1993549938 @default.
• W2022963978 cites W1994001162 @default.
• W2022963978 cites W2010330034 @default.
• W2022963978 cites W2021786002 @default.
• W2022963978 cites W2027009572 @default.
• W2022963978 cites W2032237320 @default.
• W2022963978 cites W2035100579 @default.
• W2022963978 cites W2038515691 @default.
• W2022963978 cites W2043829725 @default.
• W2022963978 cites W2044221800 @default.
• W2022963978 cites W2048680767 @default.
• W2022963978 cites W2053681756 @default.
• W2022963978 cites W2055971070 @default.
• W2022963978 cites W2065233610 @default.
• W2022963978 cites W2073663513 @default.
• W2022963978 cites W2076254516 @default.
• W2022963978 cites W2076905634 @default.
• W2022963978 cites W2079786360 @default.
• W2022963978 cites W2079923162 @default.
• W2022963978 cites W2083527679 @default.
• W2022963978 cites W2086763435 @default.
• W2022963978 cites W2086968991 @default.
• W2022963978 cites W2091461198 @default.
• W2022963978 cites W2100045859 @default.
• W2022963978 cites W2107301573 @default.
• W2022963978 cites W2122231405 @default.
• W2022963978 cites W2127440907 @default.
• W2022963978 cites W2132138672 @default.
• W2022963978 cites W2132602045 @default.
• W2022963978 cites W2150752780 @default.
• W2022963978 cites W2161825022 @default.
• W2022963978 cites W2167008563 @default.
• W2022963978 cites W2329872997 @default.
• W2022963978 cites W2429532617 @default.
• W2022963978 cites W88796997 @default.
• W2022963978 doi "https://doi.org/10.1016/s0198-8859(02)00372-5" @default.
• W2022963978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12039407" @default.
• W2022963978 hasPublicationYear "2002" @default.
• W2022963978 type Work @default.
• W2022963978 sameAs 2022963978 @default.
• W2022963978 citedByCount "23" @default.
• W2022963978 countsByYear W20229639782012 @default.
• W2022963978 countsByYear W20229639782013 @default.
• W2022963978 countsByYear W20229639782015 @default.
• W2022963978 countsByYear W20229639782016 @default.
• W2022963978 crossrefType "journal-article" @default.
• W2022963978 hasAuthorship W2022963978A5011828368 @default.
• W2022963978 hasAuthorship W2022963978A5021379796 @default.
• W2022963978 hasAuthorship W2022963978A5024848629 @default.
• W2022963978 hasAuthorship W2022963978A5065048439 @default.
• W2022963978 hasAuthorship W2022963978A5087265840 @default.
• W2022963978 hasConcept C129374314 @default.
• W2022963978 hasConcept C139563560 @default.
• W2022963978 hasConcept C147483822 @default.
• W2022963978 hasConcept C153911025 @default.
• W2022963978 hasConcept C154317977 @default.
• W2022963978 hasConcept C167672396 @default.
• W2022963978 hasConcept C202751555 @default.
• W2022963978 hasConcept C203014093 @default.
• W2022963978 hasConcept C2776090121 @default.
• W2022963978 hasConcept C37386791 @default.
• W2022963978 hasConcept C55493867 @default.
• W2022963978 hasConcept C67662055 @default.
• W2022963978 hasConcept C86803240 @default.
• W2022963978 hasConcept C8891405 @default.
• W2022963978 hasConceptScore W2022963978C129374314 @default.
• W2022963978 hasConceptScore W2022963978C139563560 @default.
• W2022963978 hasConceptScore W2022963978C147483822 @default.
• W2022963978 hasConceptScore W2022963978C153911025 @default.
• W2022963978 hasConceptScore W2022963978C154317977 @default.
• W2022963978 hasConceptScore W2022963978C167672396 @default.

• next