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• W2022969255 abstract "Summary. This work proved that nitroimidazole antiprotozoal agents, such as metronidazole, ornidazole, secnidazole and tinidazole, in concentrations of up to 64 μg ml ‐1 did not present any antifungal activity against 17 strains of Candida albicans. The combination of each drug with amphotericin B showed the occurrence of variable interactions according to the studied strain. Promising results were observed based on synergistic and additive interactions of the polyene with the metronidazole; the inhibitory and lethal activities of the drugs were potentiated against all strains in concentrations reachable in vivo. Zusammenfassung. In der vorliegenden Studie konnte gezeigt werden, daß die Nitroimidazol‐Antiparasitika Metronidazol, Ornidazol, Secnidazol und Tinidazol in Konzentrationen bis zu 64 μg ml ‐1 allein keine antimyzetische Aktivität gegen 17 C. albicans ‐Stämme aufwiesen. Die Anwendung dieser Agenzien gemeinsam mit Amphotericin B zeigte unterschiedliche Wirkungen auf die untersuchten Stämme. Erfolgversprechende Ergebnisse wurden als synergistische und additive Effekte bei der Kombination der einzelnen Nitroimidazole mit Amphotericin B beobachtet. Konzentrationen, die in vivo anwendbar sind, potenzierten die inhibitorischen und letalen Aktivitäten der Agenzien gegen alle untersuchten C. albicans ‐Stämme." @default.
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• W2022969255 date "1997-10-01" @default.
• W2022969255 modified "2023-09-27" @default.
• W2022969255 title "Interactions between amphotericin B and nitroimidazoles againstCandida albicans" @default.
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• W2022969255 doi "https://doi.org/10.1111/j.1439-0507.1997.tb00212.x" @default.
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