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- W2022969300 abstract "4-Alkylidene-β-lactones (hetero ketene dimers) and α-amino acids are useful precursors for total syntheses of the β-lactone-containing proteasome inhibitors salinosporamide A, cinnabaramide A, and derivatives. A key step is a nucleophile-promoted, bis-cyclization of keto acids that simultaneously generates the γ-lactam and β-lactone of these natural products. This reaction sequence may have implications for the biosynthesis of these natural products." @default.
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- W2022969300 date "2007-05-01" @default.
- W2022969300 modified "2023-10-14" @default.
- W2022969300 title "Concise Total Synthesis of (±)-Salinosporamide A, (±)-Cinnabaramide A, and Derivatives via a Bis-cyclization Process: Implications for a Biosynthetic Pathway?" @default.
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- W2022969300 doi "https://doi.org/10.1021/ol070616u" @default.
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