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- W2022971351 abstract "Shrinkage and collapse of the neuritic network are often observed during the process of neuronal apoptosis. However, the molecular and biochemical basis for the axonal damage associated with neuronal cell death is still unclear. We present evidence for the involvement of axon guidance molecules with repulsive cues in neuronal cell death. Using the differential display approach, an up-regulation of collapsin response mediator protein was detected in sympathetic neurons undergoing dopamine-induced apoptosis. A synchronized induction of mRNA of the secreted collapsin-1 and the intracellular collapsin response mediator protein that preceded commitment of neurons to apoptosis was detected. Antibodies directed against a conserved collapsin-derived peptide provided marked and prolonged protection of several neuronal cell types from dopamine-induced apoptosis. Moreover, neuronal apoptosis was inhibited by antibodies against neuropilin-1, a putative component of the semaphorin III/collapsin-1 receptor. Induction of neuronal apoptosis was also caused by exposure of neurons to semaphorin III-alkaline phosphatase secreted from 293EBNA cells. Anti-collapsin-1 antibodies were effective in blocking the semaphorin III-induced death process. We therefore suggest that, before their death, apoptosis-destined neurons may produce and secrete destructive axon guidance molecules that can affect their neighboring cells and thus transfer a death signal across specific and susceptible neuronal populations." @default.
- W2022971351 created "2016-06-24" @default.
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- W2022971351 date "2001-12-25" @default.
- W2022971351 modified "2023-09-27" @default.
- W2022971351 title "Semaphorins as Mediators of Neuronal Apoptosis" @default.
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- W2022971351 cites W1968074797 @default.
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- W2022971351 cites W1970318336 @default.
- W2022971351 cites W1972693595 @default.
- W2022971351 cites W1973150820 @default.
- W2022971351 cites W1978146656 @default.
- W2022971351 cites W1978368163 @default.
- W2022971351 cites W1982828428 @default.
- W2022971351 cites W1987237521 @default.
- W2022971351 cites W1988698986 @default.
- W2022971351 cites W1990983421 @default.
- W2022971351 cites W1991865867 @default.
- W2022971351 cites W1992881221 @default.
- W2022971351 cites W1999224926 @default.
- W2022971351 cites W2003766638 @default.
- W2022971351 cites W2007067622 @default.
- W2022971351 cites W2010430324 @default.
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- W2022971351 cites W2016897980 @default.
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- W2022971351 cites W2032187724 @default.
- W2022971351 cites W2032841404 @default.
- W2022971351 cites W2039355845 @default.
- W2022971351 cites W2041700814 @default.
- W2022971351 cites W2043804690 @default.
- W2022971351 cites W2045711003 @default.
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- W2022971351 cites W2050686031 @default.
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- W2022971351 cites W2057803128 @default.
- W2022971351 cites W2060982272 @default.
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- W2022971351 cites W2064173164 @default.
- W2022971351 cites W2064779214 @default.
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- W2022971351 cites W2118999426 @default.
- W2022971351 cites W2122121550 @default.
- W2022971351 cites W2123113903 @default.
- W2022971351 cites W2124248841 @default.
- W2022971351 cites W2129902275 @default.
- W2022971351 cites W2154745705 @default.
- W2022971351 cites W2164826175 @default.
- W2022971351 cites W32239881 @default.
- W2022971351 cites W4211045864 @default.
- W2022971351 cites W87631157 @default.
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- W2022971351 doi "https://doi.org/10.1046/j.1471-4159.1999.0730961.x" @default.
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