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• W2022971462 endingPage "3541" @default.
• W2022971462 startingPage "3530" @default.
• W2022971462 abstract "In Comamonas testosteroni BR60 (formerly Alcaligenes sp. strain BR60), catabolism of the pollutant 3-chlorobenzoate (3CBA) is initiated by enzymes encoded by cbaABC, an operon found on composite transposon Tn5271 of plasmid pBRC60. The cbaABC gene product CbaABC converts 3CBA to protocatechuate (PCA) and 5-Cl-PCA, which are then metabolized by the chromosomal PCA meta (extradiol) ring fission pathway. In this study, cbaA was found to possess a sigma(70) type promoter. O(2) uptake experiments with whole cells and expression studies with cbaA-lacZ constructs showed that cbaABC was induced by 3CBA. Benzoate, which is not a substrate of the 3CBA pathway, was a gratuitous inducer, and CbaR, a MarR family repressor coded for by a divergently transcribed gene upstream of cbaABC, could modulate induction mediated by benzoate. Purified CbaR bound specifically to two regions of the cbaA promoter (P(cbaA)); site I, a high-affinity site, is between the transcriptional start point (position +1) and the start codon of cbaA, while site II, a lower-affinity site, overlaps position +1. 3CBA at concentrations as low as 40 microM interfered with binding to P(cbaA). PCA also interfered with binding, while benzoate only weakly disrupted binding. Unexpectedly, benzoate with a hydroxyl or carboxyl at position 3 improved CbaR binding. Data are also presented that suggest that an unidentified regulator is encoded on the chromosome that induces cbaABC in response to benzoate and 3CBA." @default.
• W2022971462 created "2016-06-24" @default.
• W2022971462 creator A5006522201 @default.
• W2022971462 creator A5050383293 @default.
• W2022971462 date "2001-08-01" @default.
• W2022971462 modified "2023-10-16" @default.
• W2022971462 title "Identification and Functional Characterization of CbaR, a MarR-Like Modulator of the <i>cbaABC</i> -Encoded Chlorobenzoate Catabolism Pathway" @default.
• W2022971462 cites W1485341307 @default.
• W2022971462 cites W1501179103 @default.
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• W2022971462 cites W1531301955 @default.
• W2022971462 cites W1586662827 @default.
• W2022971462 cites W1600494952 @default.
• W2022971462 cites W1636002209 @default.
• W2022971462 cites W1675011399 @default.
• W2022971462 cites W1903446705 @default.
• W2022971462 cites W1930218638 @default.
• W2022971462 cites W193267154 @default.
• W2022971462 cites W1933529100 @default.
• W2022971462 cites W1945390289 @default.
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• W2022971462 cites W1972010400 @default.
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• W2022971462 cites W1997215133 @default.
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• W2022971462 cites W2137840411 @default.
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• W2022971462 cites W2143705316 @default.
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• W2022971462 cites W2150507433 @default.
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• W2022971462 doi "https://doi.org/10.1128/aem.67.8.3530-3541.2001" @default.
• W2022971462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/93053" @default.
• W2022971462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11472929" @default.
• W2022971462 hasPublicationYear "2001" @default.
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