Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022973321> ?p ?o ?g. }
- W2022973321 endingPage "57" @default.
- W2022973321 startingPage "49" @default.
- W2022973321 abstract "The generation of cellular forces and the application of these physical forces to the ECM play a central role in mediating matrix patterning and remodeling during fundamental processes such as developmental morphogenesis and wound healing. In addition to growth factors and other biochemical factors that can modulate the keratocyte mechanical phenotype, another key player in the regulation of cell-induced ECM patterning is the mechanical state of the ECM itself. In this review we provide an overview of the biochemical and biophysical factors regulating the mechanical interactions between corneal keratocytes and the stromal ECM at the cellular level. We first provide an overview of how Rho GTPases regulate the sub-cellular pattern of force generation by corneal keratocytes, and the impact these forces have on the surrounding ECM. We next review how feedback from local matrix structural and mechanical properties can modulate keratocyte phenotype and mechanical activity. Throughout this review, we provide examples of how these biophysical interactions may contribute to clinical outcomes, with a focus on corneal wound healing." @default.
- W2022973321 created "2016-06-24" @default.
- W2022973321 creator A5034903520 @default.
- W2022973321 creator A5078259243 @default.
- W2022973321 date "2015-04-01" @default.
- W2022973321 modified "2023-10-16" @default.
- W2022973321 title "Mechanical interactions and crosstalk between corneal keratocytes and the extracellular matrix" @default.
- W2022973321 cites W144793108 @default.
- W2022973321 cites W1499860213 @default.
- W2022973321 cites W1513199670 @default.
- W2022973321 cites W1529402516 @default.
- W2022973321 cites W1531596839 @default.
- W2022973321 cites W1541525317 @default.
- W2022973321 cites W1580831370 @default.
- W2022973321 cites W175266247 @default.
- W2022973321 cites W1963892111 @default.
- W2022973321 cites W1966174614 @default.
- W2022973321 cites W1966966089 @default.
- W2022973321 cites W1972507748 @default.
- W2022973321 cites W1973089587 @default.
- W2022973321 cites W1974489896 @default.
- W2022973321 cites W1974797581 @default.
- W2022973321 cites W1977277272 @default.
- W2022973321 cites W1977661506 @default.
- W2022973321 cites W1978054070 @default.
- W2022973321 cites W1981169249 @default.
- W2022973321 cites W1985015512 @default.
- W2022973321 cites W1986532418 @default.
- W2022973321 cites W1988025887 @default.
- W2022973321 cites W1988124945 @default.
- W2022973321 cites W1988870663 @default.
- W2022973321 cites W1992121419 @default.
- W2022973321 cites W1993478731 @default.
- W2022973321 cites W1995191934 @default.
- W2022973321 cites W1995479855 @default.
- W2022973321 cites W1995769675 @default.
- W2022973321 cites W1996017044 @default.
- W2022973321 cites W1996071947 @default.
- W2022973321 cites W1997087774 @default.
- W2022973321 cites W1998273598 @default.
- W2022973321 cites W2000075742 @default.
- W2022973321 cites W2002244424 @default.
- W2022973321 cites W2004163365 @default.
- W2022973321 cites W2007813321 @default.
- W2022973321 cites W2011093418 @default.
- W2022973321 cites W2011405727 @default.
- W2022973321 cites W2013361987 @default.
- W2022973321 cites W2015640627 @default.
- W2022973321 cites W2015707596 @default.
- W2022973321 cites W2021520049 @default.
- W2022973321 cites W2021561041 @default.
- W2022973321 cites W2024250498 @default.
- W2022973321 cites W202564419 @default.
- W2022973321 cites W2025937300 @default.
- W2022973321 cites W2028502053 @default.
- W2022973321 cites W2032295238 @default.
- W2022973321 cites W2034282738 @default.
- W2022973321 cites W2035727898 @default.
- W2022973321 cites W2036634122 @default.
- W2022973321 cites W2037093699 @default.
- W2022973321 cites W2040016239 @default.
- W2022973321 cites W2040422920 @default.
- W2022973321 cites W2041512284 @default.
- W2022973321 cites W2046794957 @default.
- W2022973321 cites W2050406525 @default.
- W2022973321 cites W2050659938 @default.
- W2022973321 cites W2051005427 @default.
- W2022973321 cites W2056029035 @default.
- W2022973321 cites W2056977603 @default.
- W2022973321 cites W2058117121 @default.
- W2022973321 cites W2059635245 @default.
- W2022973321 cites W2059787231 @default.
- W2022973321 cites W2065987595 @default.
- W2022973321 cites W2067658360 @default.
- W2022973321 cites W2068367752 @default.
- W2022973321 cites W2072566967 @default.
- W2022973321 cites W2075988861 @default.
- W2022973321 cites W2077109808 @default.
- W2022973321 cites W2078992684 @default.
- W2022973321 cites W2080268492 @default.
- W2022973321 cites W2081919740 @default.
- W2022973321 cites W2083476264 @default.
- W2022973321 cites W2086002627 @default.
- W2022973321 cites W2086223927 @default.
- W2022973321 cites W2086432076 @default.
- W2022973321 cites W2089690011 @default.
- W2022973321 cites W2091508582 @default.
- W2022973321 cites W2093956551 @default.
- W2022973321 cites W2096969026 @default.
- W2022973321 cites W2098313852 @default.
- W2022973321 cites W2098525297 @default.
- W2022973321 cites W2102312968 @default.
- W2022973321 cites W2102533478 @default.
- W2022973321 cites W2102772179 @default.
- W2022973321 cites W2105789974 @default.
- W2022973321 cites W2106324055 @default.
- W2022973321 cites W2108038175 @default.
- W2022973321 cites W2112668385 @default.